A5071408406- Healthcare Systems and Public Health
- Hepatitis B Virus Studies
- SARS-CoV-2 and COVID-19 Research
- Hepatitis C virus research
- Human Health and Disease
- COVID-19 Clinical Research Studies
- Bacteriophages and microbial interactions
- COVID-19 epidemiological studies
- Antibiotic Resistance in Bacteria
- Pediatric health and respiratory diseases
- Respiratory viral infections research
- Viral Infections and Vectors
- Viral gastroenteritis research and epidemiology
- Hepatitis Viruses Studies and Epidemiology
- Yersinia bacterium, plague, ectoparasites research
- Long-Term Effects of COVID-19
- Liver Disease Diagnosis and Treatment
- Animal Virus Infections Studies
- Antibiotic Use and Resistance
- CRISPR and Genetic Engineering
- Bacterial biofilms and quorum sensing
- Vector-borne infectious diseases
- Influenza Virus Research Studies
- COVID-19 Impact on Reproduction
- Pneumonia and Respiratory Infections
Central Research Institute of Epidemiology
2014-2025
Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing
2015-2025
North-Western State Medical University named after I.I. Mechnikov
2025
Central Research Institute
2020-2024
Centers for Disease Control and Prevention
2023
National Center for Emerging and Zoonotic Infectious Diseases
2023
Russian Academy of Sciences
2019-2021
Federal Scientific Center for Medical and Preventive Health Risk Management Technologies
2021
Perm State University
2021
Republican Scientific and Practical Center of Cardiology
2021
An epidemic of COVID-19 (Coronavirus disease 2019) etiologically associated with the SARS-CoV-2 (Severe acute respiratory syndrome-related coronavirus 2) that occurred at turn 2019–2020 firstly in Wuhan (Hubei province China) and then spread to many countries around world rose a new wave interest coronaviruses. The first coronaviruses – members Coronaviridae family belonging order Nidovirales — were discovered half last century. human coronavirus, HCoV-B814, was isolated 1965 not preserved...
Background. The ongoing pandemic of a new coronavirus infection (COVID-19) determines the relevance analysis epidemiological patterns SARS-CoV-2 spread among population Russian Federation.Aim — study manifestations epidemic process COVID-19 in Federation 2020–2022.Materials and methods. A retrospective incidence was carried out from 03/30/2020 to 04/24/2022. data Rospotrebnadzor report No. 970 “Information on cases infectious diseases persons with suspected infection”, information portal...
Klebsiella pneumoniae, which is frequently associated with hospital- and community-acquired infections, contains multidrug-resistant (MDR), hypervirulent (hv), non-MDR/non-hv as well convergent representatives. It known that mostly international high-risk clonal lineages including sequence types (ST) 11, 147, 258, 307 drive their global spread. ST395, was first reported in the context of a carbapenemase-associated outbreak France 2010, less well-characterized, yet emerging lineage.
Abstract Background The dual infection with SARS-CoV-2 is poorly described and currently under discussion. We present a study of two strains detected in the same patient during disease presentation. Case presentation A their 90 s was hospitalised fever. Oropharyngeal swab obtained on next day (sample 1) tested positive for SARS-CoV-2. Five days later, transferred to ICU (intensive care unit) hospital specialising treatment COVID-19 patients, where patient's condition progressively worsened...
Delta has outcompeted most preexisting variants of SARS-CoV-2, becoming the globally predominant lineage by mid-2021. Its subsequent evolution led to emergence multiple sublineages, which are well-mixed between countries. By contrast, here we show that nearly entire epidemic in Russia probably descended from a single import event, or closely timed imports poorly sampled geographic location. Indeed, over 90 per cent samples characterized nsp2:K81N + ORF7a:P45L pair mutations is rare outside...
Background. The ongoing pandemic of the novel coronavirus infection (COVID-19) draws attention to significance molecular and genetic monitoring SARS-CoV-2 spread among population Russian Federation. aim study was analyze dynamics circulation variants in Russia.Materials methods. analysis for Russia carried out, covering period from 28/12/2020 26/6/2022. included data Rospotrebnadzor Report No. 970 "Information about Infectious Diseases Individuals with Suspected Novel Coronavirus Infection"...
The topic of epidemiologic surveillance is one the basic concepts in theory and practice science. In Russia, generalization accumulated factual material theoretical developments have allowed us to formulate a number provisions on nature epidemic process. pandemic new coronavirus infection has forced adjustments all spheres society, including activities infectious disease epidemiological system, requiring development implementation innovative solutions. Based experience prompt response tasks...
The COVID-19 pandemic, etiologically related to a new coronavirus, has had catastrophic impact on the demographic situation global scale. aim of this study was analyze manifestations epidemic process, dynamics circulation, and rate spread variants SARS-CoV-2 virus in Russian Federation. Retrospective epidemiological analysis incidence from March 2020 fall 2023 molecular genetic monitoring variability using next-generation sequencing technologies bioinformatics methods were performed. Two...
Klebsiella pneumoniae is one of the most important pathogens concerned with multidrug resistance in healthcare-associated infections. The treating infections caused by this bacterium complicated due to emergence and rapid spreading carbapenem-resistant strains, which are associated high mortality rates. Recently, several hypervirulent carbapenemase-producing isolates were reported that make situation even more complicated. In order better understand virulence mechanisms, and, turn, develop...
Acinetobacter baumannii is an opportunistic pathogen being one of the most important causative agents a wide range nosocomial infections associated with multidrug resistance and high mortality rate. This study presents multiparametric correlation analyses clinical multidrug-resistant A. isolates using short- long-read whole-genome sequencing, which allowed us to reveal specific characteristics different CRISPR/Cas systems. We also compared antibiotic virulence gene acquisition for groups...
Introduction. Since the outbreak of COVID-19 pandemic caused by SARS-CoV-2 novel coronavirus, international community has been concerned about emergence mutations altering some biological properties pathogen like increasing its infectivity or virulence. Particularly, since end 2020, several variants concern have identified around world, including Alpha (B.1.1.7), Beta (B.1.351), Gamma (P.1), and Delta (B.1.617.2). However, existing mechanism detecting important are not always effective...
In 2021, a patient died from Marburg virus (MARV) disease in Guinea and it was the first confirmed case West Africa. The origin of outbreak has not been identified. It revealed that didn't travel anywhere before illness. Prior to outbreak, MARV had found bats neighboring Sierra Leone, but never Guinea. Therefore, infection is unclear: an autochthonous with spillover local population or imported fruit foraging/migrating Leone? this paper, we studied Rousettus aegyptiacus as possible source...
Patients with oncological and hematological diseases are at high risk of nosocomial bloodborne infections (hepatitis B, hepatitis C, HIV) due to their immunosuppressed condition highly invasive treatment. The aim our study is identify the key factors acquiring among patients determine causes uneven prevalence B C main clinical groups patients. was carried out from 2021 2023. cohort consisted 500 patients, 100 in each group: primary immunodeficiencies PID), disorders blood blood-forming...
The infections of bacterial origin represent a significant problem to the public healthcare worldwide both in clinical and community settings. Recent decade was marked by limiting treatment options for due growing antimicrobial resistance (AMR) acquired transferred various species, especially ones causing healthcare-associated infections, which has become dangerous issue noticed World Health Organization. Numerous reports shown that spread AMR is often driven several species-specific...
Relevance . Hepatitis B virus (HBV) is the etiologic agent of acute and chronic hepatitis in humans. WHO recommends use sensitive laboratory assays based on nucleic acid amplification methods to detect HBV DNA. A method for detecting single copies DNA using CRISPR/Cas systems was previously developed ultrasensitive detection Aims The aim present study optimize systems. Materials To obtain amplified fragments genome, 22 oligonucleotides were developed. preliminary stage performed by RPA...
Over the past 30 years, amount of sequencing data has increased significantly, including for human immunodeficiency virus type 1 (HIV-1). Significant developments have also occurred in field bioinformatics. Because this, first science and then practical healthcare, a new emerged — genomic surveillance. Currently, possibilities using bioinformatics methods are practically not described Russian regulatory documents. This review outlines main applications surveillance HIV infection: analysis...
Objective . To conduct a medical and social analysis of the patients› demand for emergency care uncontrolled arterial hypertension in St. Petersburg to calculate expected economic effect. Objectives study. 1. study structure visits connection with increased blood pressure assess their five-year survival rate, as well identify most common conditions; 2. prevalence, dynamics treatments, distribution by gender age patients associated during 2015–2017; 3. Using neural networks, predict changes...
The persistence of human immunodeficiency virus (HIV) within viral reservoirs poses significant challenges to eradication efforts. Epigenetic alterations, including DNA methylation, are potential factors influencing the latency and HIV. This study details development application techniques assess CpG methylation in promoter regions CCR5 CXCR4 genes, which key HIV-1 coreceptors. Using both Sanger sequencing pyrosequencing methods, we examined 51 biological samples from 17 people living with...
Acinetobacter baumannii is a dangerous bacterial pathogen possessing the ability to persist on various surfaces, especially in clinical settings, and rapidly acquire resistance broad spectrum of antibiotics. Thus, epidemiological surveillance A. within particular hospital, region, across world an important healthcare task that currently usually includes performing whole-genome sequencing (WGS) representative isolates. During past years, dissemination was mainly driven by strains belonging...
We present the results of a randomized, double-blind, placebo-controlled, multi-center clinical trial phase I/II tolerability, safety, and immunogenicity inactivated whole virion concentrated purified coronavirus vaccine CoviVac in volunteers aged 18-60 open comparative IIb 60 years older. The safety was assessed 400 age cohort who received two doses (n = 300) or placebo 100) 200 60+ all whom three vaccine. studied has shown good tolerability safety. No deaths, serious adverse events (AEs),...
Relevance . Despite the successes achieved over 85-year history of study tick-borne encephalitis (TBE), there are still many controversial and unresolved issues. It is obvious that in second decade XXI century, this natural focal neuroinfection, as before, poses a great threat to public health not only Russia, but also endemic countries world. Aim To present modern aspects etiology, epidemiology, diagnosis, specific prevention TBE Russia Conclusions Currently, 4 genotypes virus: Far Eastern,...