A5012477860- Exercise and Physiological Responses
- Diabetes Management and Research
- Muscle metabolism and nutrition
- Mechanical Circulatory Support Devices
- Pancreatic function and diabetes
- Microfluidic and Capillary Electrophoresis Applications
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Cardiac pacing and defibrillation studies
- Diabetes and associated disorders
- High Altitude and Hypoxia
- Intravenous Infusion Technology and Safety
- Sports Performance and Training
- Blood properties and coagulation
- Cardiac and Coronary Surgery Techniques
- Central Venous Catheters and Hemodialysis
- Diet and metabolism studies
- Heparin-Induced Thrombocytopenia and Thrombosis
- Wireless Power Transfer Systems
- Analytical Chemistry and Sensors
- Cancer, Hypoxia, and Metabolism
- Animal Behavior and Welfare Studies
- RNA regulation and disease
- RNA modifications and cancer
- Glioma Diagnosis and Treatment
- Neurological disorders and treatments
University Hospital Bonn
2024-2025
University of Bonn
2024-2025
Universidade Federal de São Paulo
2024
Universität Greifswald
2023
University of Minnesota
1993-2013
University of Minnesota System
1979-2008
Twin Cities Orthopedics
1978-2004
University of Minnesota Medical Center
1985-2002
Rigshospitalet
1992-2001
In-Q-Tel
2000
1 The present study investigates to what extent and by which time course prolonged strenuous exercise influences the plasma concentration of pro-inflammatory inflammation responsive cytokines as well cytokine inhibitors anti-inflammatory cytokines. 2 Ten male subjects (median age 27.5 years, range 24–37) completed Copenhagen Marathon 1997 running 3:26 (h:min), 2:40–4:20). Blood samples were obtained before, immediately after then every 30 min in a 4 h post-exercise recovery period. 3...
1. This study was performed to test the hypothesis that inflammatory cytokines are produced in skeletal muscle response prolonged intense exercise. Muscle biopsies and blood samples were collected from runners before, immediately after, 2 h after a marathon race. 2. The concentration of interleukin (IL)-6 protein plasma increased 1.5 +/- 0.7 94.4 12.6 pg ml-1 post-exercise 22.1 3.8 post-exercise. IL-1 receptor antagonist (IL-1ra) 123 23 2795 551 ml-1, further 4119 527 3. comparative...
Intraarterial infusion chemotherapy has several theoretical advantages over conventional therapy for the treatment of unresectable malignancies. However, catheter problems and patient restriction to hospital associated with its use have resulted in infrequent application a notable lack progress this field oncology. This paper describes totally implantable, percutaneously refillable pump 5 patients primary or metastatic carcinoma liver. The cannulae were placed into hepatic arteries under...
Klebsiella pneumoniae, which is frequently associated with hospital- and community-acquired infections, contains multidrug-resistant (MDR), hypervirulent (hv), non-MDR/non-hv as well convergent representatives. It known that mostly international high-risk clonal lineages including sequence types (ST) 11, 147, 258, 307 drive their global spread. ST395, was first reported in the context of a carbapenemase-associated outbreak France 2010, less well-characterized, yet emerging lineage.
Strenuous exercise is accompanied by an increase in circulating proinflammatory and inflammation responsive cytokines, having some similarities with the response to sepsis trauma. The sequential release of tumour necrosis factor-alpha, interleukin (IL)1beta, IL-6, IL-1 receptor antagonist (IL-1ra) blood comparable that observed relation bacterial diseases. Eccentric associated serum IL-6 concentrations significantly correlated concentration creatine kinase (CK) following days, whereas no...
Effect of glutamine supplementation on changes in the immune system induced by repeated exercise. Med. Sci. Sports Exerc., Vol. 30, No. 6, pp. 856-862, 1998. The ability lymphocytes to proliferate and generate lymphokine activated killer (LAK) cell activity vitro is dependent glutamine. In relation intense exercise lymphocyte concentration, proliferative response, natural LAK activity, plasma concentration decline. It has been hypothesized that physical a lack may temporarily affect function...
To study the relationship between exercise-related muscle proteolysis and cytokine response, a prolonged eccentric exercise model of one leg was used. Subjects performed two trials [a branched-chain amino acid (BCAA) supplementation control trial]. The release acids from during after decreased in BCAA trial, suggesting suppression net protein degradation. plasma concentrations interleukin (IL)-6 increased 0.75 +/- 0.19 (preexercise) to 5.02 0.96 pg/ml (2 h postexercise) trial 1.07 0.41 4.15...
The present in vitro study was conducted to examine how glutamine influences the lymphocyte function. Glutamine had no effect on production of interleukin‐1β, interleukin‐6 or tumour necrosis factor‐α, but influenced interleukin‐2 and interferon‐γ. Glutamate, leucine, isoleucine valine (substrates for production), combination glutamate did not influence proliferative response cytokine production. In conclusion, some T‐cell‐derived cytokines, is thereby important optimal proliferation....
Somatic copy number alterations are a hallmark of cancer that offer unique opportunities for therapeutic exploitation. Here, we focused on the identification specific vulnerabilities tumors harboring chromosome 8p deletions. We developed and applied an integrative analysis The Cancer Genome Atlas (TCGA), Dependency Map (DepMap), Cell Line Encyclopedia to identify 8p-specific vulnerabilities. employ orthogonal gene targeting strategies, both in vitro vivo, including short hairpin RNA-mediated...
We treated five patients with Type II diabetes by means of a subcutaneously implanted intravenous insulin pump and compared their metabolic response that observed during conventional therapy. The use the improved control glycemia, as manifested reductions in mean plasma glucose (from 188±46 to 106±12 mg per deciliter [mean ±S.D.]), fasting 187±42 80±13 deciliter), postprandial 287±74 182±29 together diminution glycemic excursion normalization glycosylated hemoglobin A1 12.1 ±2 8.0±1 cent)....
Glutamine increased the proliferative response and lymphokine-activated killer cell activity of blood mononuclear cells isolated from normal healthy subjects (n = 6) in a dose-dependent manner, with optimum at 0.3-1.0 mM. The relative fraction CD3+, CD4+, CD8+, CD14+, CD16+, CD19+ was not changed by glutamine concentration 0.6 mM, except phytohemagglutinin-stimulated proliferation experiment where therefore CD3+ cells, increased. natural influenced glutamine. Human immunodeficiency virus...
Muscle glycogen remains subnormal several days after muscle damaging exercise. The aims of this study were to investigate how acid-soluble macroglycogen (MG) and acid-insoluble proglycogen (PG) pools are restored a competitive marathon also determine whether accumulates differently in the various fiber types. Six well-trained runners participated study, biopsies obtained from vastus lateralis quadriceps before, immediately after, 1, 2, 7 ( 7, respectively) marathon. During race, 56 ± 3.8%...
The Infusaid implantable infusion pump with a single delivery rate has maintained chronic intravenous heparin in man for greater than 35 mo and 5 yr the dog. Intra-arterial infuson of fluorodeoxyuridine been 8 man. In pilot study using commercially available, transcutaneously controllable, magnetically activated valve baseline superimposed bolus insulin infusion, feasibility maintaining near normal serum glucose diabetic dogs was demonstrated. effect long-term cannulation investigated; it...
Near-normal glucose tolerance tests in diabetic dogs were obtained during basal rate insulin infusions restrained animals by use of extracorporeal infusion pumps and conscious, unrestrained means implanted pumps. Even better regulation blood was the addition predetermined pulses at higher flow rates than rate, accomplished a transcutaneously activated valve mechanism attached to pump. We conclude that near-normal concentrations can be maintained throughout day dog these similar approaches,...