A5037611393- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Rabies epidemiology and control
- Bacillus and Francisella bacterial research
- Diverse Scientific Research in Ukraine
- Toxin Mechanisms and Immunotoxins
- Viral Infections and Outbreaks Research
- Viral Infectious Diseases and Gene Expression in Insects
- Viral gastroenteritis research and epidemiology
- Vaccine Coverage and Hesitancy
- Economic Issues in Ukraine
- Hepatitis B Virus Studies
- Poxvirus research and outbreaks
- COVID-19 epidemiological studies
- Viral Infections and Immunology Research
- Protein purification and stability
- Business and Economic Development
- Pharmacological Effects of Natural Compounds
- Transgenic Plants and Applications
- Insect symbiosis and bacterial influences
- Yersinia bacterium, plague, ectoparasites research
Russian Academy of Sciences
2020-2023
Chumakov Institute of Poliomyelitis and Viral Encephalitides
2021
Centre for Research and Development
2020
The unprecedented in recent history global COVID-19 pandemic urged the implementation of all existing vaccine platforms to ensure availability vaccines against every country world. Despite multitude high-quality papers describing clinical trials different products, basic detailed data on general toxicity, reproductive immunogenicity, protective efficacy and durability immune response animal models are scarce. Here, we developed a β-propiolactone-inactivated whole virion CoviVac assessed its...
We present the results of a randomized, double-blind, placebo-controlled, multi-center clinical trial phase I/II tolerability, safety, and immunogenicity inactivated whole virion concentrated purified coronavirus vaccine CoviVac in volunteers aged 18-60 open comparative IIb 60 years older. The safety was assessed 400 age cohort who received two doses (n = 300) or placebo 100) 200 60+ all whom three vaccine. studied has shown good tolerability safety. No deaths, serious adverse events (AEs),...
Global polio eradication requires both safe and effective vaccines, production processes. Sabin oral poliomyelitis vaccine (OPV) strains can evolve to virulent viruses result in outbreaks, conventional inactivated (Salk-IPV) includes accumulation of large stocks neurovirulent wild polioviruses. Therefore, IPV based on attenuated OPV seems a viable option. To increase the global supply affordable still not-polio free world we developed an made from strains–PoliovacSin. Clinical trials...
The purpose of study was to isolate arboviruses from mosquitoes different species in the cell culture and identify them by using molecular immunochemical techniques.Materials methods. Viruses were isolated C6/36 cultures. pathogens identified enzyme-linked immunosorbent assay (ELISA) kits for detection antigens dengue, Chikungunya, West Nile Sindbis viruses as well reverse transcription polymerase chain reaction (RT-PCR) with specific primers Sanger sequencing.Results. A total 102 belonging...
Rabies is an acute viral disease caused by a virus of the Rhabdoviridae family Lyssavirus genus, which affects central nervous system and characterised absolute mortality. Vaccination only way to prevent in humans. One products used for vaccination cultural concentrated purified inactivated dry rabies vaccine produced Federal State Budgetary Institution Science “Chumakov Scientific Center Research Development Immune-and-Biological Products Russian Academy Sciences” (hereinafter—Chumakov...
Introduction. Cases of Chikungunya fever have been reported in more than 100 countries Europe, Oceania, Africa, Asia, the Caribbean, and America. The musculoskeletal disorders typical for can last from several months to a year even lead disability. infection is believed provide lifelong immunity. This factor lack specific therapy make vaccination most promising method preventing fever.Materials methods. purified inactivated preparation with different doses CHIKV antigen was injected...
According to statistics, 81% of cases COVID-19 coronavirus infection occur in a mild or moderate form. These patients make up the main part flow calls general practitioner at moment. The difficulties that therapists face during pandemic are associated with finding optimal therapy for disease due gradual accumulation knowledge about new RNA-containing virus. article presents data study antiviral activity drug Lysobact Complete® vitro on Vero cell culture. Studies previous years confirm...