A5073132555- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Antiplatelet Therapy and Cardiovascular Diseases
- Platelet Disorders and Treatments
- Blood disorders and treatments
- Acute Myocardial Infarction Research
- Neuroscience and Neuropharmacology Research
- Medicinal Plants and Neuroprotection
- Venous Thromboembolism Diagnosis and Management
- Neuroscience and Neural Engineering
Sechenov University
2024
Center for Theoretical Problems of Physicochemical Pharmacology
2023-2024
Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology
2023
Russian Academy of Sciences
2005
Thromboinflammation is caused by mutual activation of platelets and neutrophils. The site thromboinflammation determined chemoattracting agents release endothelium, immune cells, platelets. Impaired neutrophil chemotaxis contributes to the pathogenesis Shwachman-Diamond syndrome (SDS). In this hereditary disorder, neutrophils are known have aberrant chemoattractant-induced F-actin properties. Here, we aim determine whether could be analyzed using our previously developed ex vivo assay...
The assessment of platelet dysfunction is usually used by hematologists to diagnose inherited (such as Bernard-Soulier syndrome, platelet-type-von Willebrand disease, Glanzmann thrombasthenia, etc.), and acquired (symptomatic) disorders (in hemoblastoses, uremia, liver cirrhosis, well predict the risk intraoperative bleeding in these groups patients. Later, laboratory function tests began be cardiologists, first experimental clinical studies. In further years, attempts were made introduce...