A5051420964- Cardiac Valve Diseases and Treatments
- Aortic Disease and Treatment Approaches
- Cardiovascular Issues in Pregnancy
- Aortic aneurysm repair treatments
- Pulmonary Hypertension Research and Treatments
- Congenital Heart Disease Studies
- Connective tissue disorders research
- Cardiac Structural Anomalies and Repair
- Infective Endocarditis Diagnosis and Management
- Cardiac, Anesthesia and Surgical Outcomes
- Bone Metabolism and Diseases
- Lipoproteins and Cardiovascular Health
- Cardiovascular Function and Risk Factors
- Orthopaedic implants and arthroplasty
- Cardiac Imaging and Diagnostics
- Cardiomyopathy and Myosin Studies
- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Congenital heart defects research
- Adipose Tissue and Metabolism
- Biomarkers in Disease Mechanisms
- Aortic Thrombus and Embolism
- Peroxisome Proliferator-Activated Receptors
- Advanced X-ray and CT Imaging
- Cell Adhesion Molecules Research
Federal Almazov North-West Medical Research Centre
2015-2024
Russian Society of Cardiology
2022
ITMO University
2016-2017
Ministry of Health of the Russian Federation
2016
The Russian Society of Cardiology (RKO) With the participation of: National for Study Atherosclerosis (NOA), Association Endocrinologists (RAE), Cardiosomatic Rehabilitation and Secondary Prevention (RosOKR), Scientific Medical Therapists (RNMOT), Eurasian Cardiologists, (EAT), Gerontologists Geriatricians
The Russian Society of Cardiology (RKO) With the participation of: Scientific Medical Internal Medicine (RSMSIM) Approved by Research and Practical Council Ministry Health Federation (12.09.2024)
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Russian Society of Cardiology (RSC) With the participation Eurasian Association Therapists, Scientific Medical Therapists (RNMOT), Pathologists, Radiologists and (RSR) Approved by Practical Council Ministry Health (30.09.2022)
Thoracic aortic aneurysm develops as a result of complex series events that alter the cellular structure and composition extracellular matrix wall. The purpose present work was to study functions endothelial smooth muscle cells from patients with aneurysms thoracic aorta. We studied in bicuspid valve tricuspid valve. expression key markers (CD31, vWF, VE-cadherin) (SMA, SM22α, calponin, vimentin) well MMP activity apoptosis cell proliferation. Expression functional reduced patient cells....
Russian Society of Cardiology (RSC) With the participation: Association Cardiovascular Surgeons Endorsed by: Research and Practical Council Ministry Health Federation Task Force : Gabrusenko S.A. (Chairman), Gudkova A.Ya.* Koziolova N.A. Alexandrova S.A., Berseneva M.I., Gordeev M.L., Dzemeshkevich S.L., Zaklyazminskaya E.V., Irtyuga O.B., Kaplunova V.Yu., Kostareva A.A., Krutikov A.N., Malenkov D.A., Novikova T.N., Saidova M.A., Sanakoev M.K., Stukalova O.V.
Carotid stenosis is a multidisciplinary problem that requires the involvement of specialists’ team, including cardiovascular surgeons, neurosurgeons, endovascular cardiologists, neurologists, and internists. In this consensus statement, group experts considered main stages diagnosing carotid stenosis, as well discussed, necessary prevention methods features choosing optimal treatment approach. The aim was to provide concise structured information on management patients with stenosis. This...
Background . The NOTCH pathway is known to be important in the pathogenesis of calcific aortic valve disease, possibly through regulators osteoprotegerin (OPG), receptor activator nuclear factor κ B (RANK), and its ligand (RANKL) system. purpose present study was search for possible associations between NOTCH1 gene mutations circulating levels OPG soluble RANKL (sRANKL) patients with stenosis (AS). Methods performed on 61 AS including 31 bicuspid 30 tricuspid valves. We applied a strategy...
Cellular and molecular mechanisms of thoracic aortic aneurysm are not clear therapeutic approaches mostly absent. Thoracic is associated with defective differentiation smooth muscle cells (SMC) wall. Bicuspid valve (BAV) comparing to tricuspid (TAV) significantly predisposes a risk aneurysms. It has been suggested recently that BAV-associated aortopathies represent separate pathology TAV-associated dilations. The only proven candidate gene BAV remains NOTCH1. In this study we tested the...
Russian Society of Cardiology (RCS)
The NOTCH-signaling pathway is responsible for intercellular interactions and cell fate commitment. Recently, NOTCH genes were demonstrated to play an important role in aortic valve development, leading increased calcified disease (CAVD) later life. Here, we further investigate the association between genetic variants stenosis a case–control study of 90 CAVD cases 4723 controls using target panel sequencing full-length 20 from NOTCH-related (DVL2, DTX2, MFNG, NUMBL, LFNG, DVL1, DTX4, APH1A,...
We here sought to assess thrombotic and hemorrhagic complications associated risk factors during pregnancy, delivery, postpartum in women with prosthetic heart valves (PHV).
Russian Society of Cardiology (RSC) Developed with the special contribution Functional Diagnostics Association, Holter Monitoring and Non-invasive Electrophysiology Society, Pediatric Association.
Aortic stenosis (AS) is the most commonly diagnosed valvular heart disease, and its prevalence increases with aging of general population. However, AS often at a severe stage, necessitating surgical treatment, due to long asymptomatic period. The objective this study was analyze frequency in population cardiovascular patients using echocardiography (ECHO) identify clinical factors features associated these patient groups. We utilized machine learning methods 84,851 echocardiograms performed...
The study aimed to compare composition of peripheral blood T-cell subsets and assess their surface expression CD39 CD73 ectonucleotidases in patients with severe moderate aortic stenosis (AS) as well evaluate involvement T-cell-mediated immune processes valve calcification. was performed 38 suffering from calcified (SAS), 33 MAS, 30 apparently healthy volunteers (HVs). relative distribution percentage expressing were evaluated by flow cytometry. T helper (Th) cytotoxic (Tcyt) identified...
Aortopulmonary window is a rare congenital heart defect that results in severe pulmonary arterial hypertension (PAH), Eisenmenger syndrome, and congestive failure the first months of life. Pregnancy absolutely contraindicated patients with this condition.This paper describes two clinical cases pregnancy (28 20 years old) aortopulmonary defect, PAH, syndrome ended preterm delivery by caesarean section. One patient died postpartum period due to progression right ventricular failure. The...
Aim. The study focused on the analysis of short-term results aortic arch reconstruction in patients undergoing open heart surgery for ascending aneurysms and dissections, comparison intra-operative brain protection methods verification predictors complications.Methods. 84 (mean age 55.5 ± 11.5 years, 72.6 % (61) males) with Stanford type A dissections underwent over a period from January, 2013, to March, 2015. Patients were divided into 3 groups. 1st group included aneurysm combined...
Aim . To modernize the computed tomography angiography (CTA) protocol with advanced data processing for diagnosis of ascending aortic (AA) aneurysms, determining distensibility and compliance. Material methods We examined 24 patients (14 men) aged 43 to 72 years old aneurysm or dilatation aorta (AA). CTA was performed on Siemens Somatom Definition AS Philips Ingenuity Elite 128-slice scanners electrocardiographic (ECG) synchronization after a bolus injection contrast agents (100-120 ml)....