A5018706513- Acute Myocardial Infarction Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Lipoproteins and Cardiovascular Health
- Cardiac Imaging and Diagnostics
- Atrial Fibrillation Management and Outcomes
- COVID-19 Clinical Research Studies
- Healthcare Systems and Public Health
- Blood Pressure and Hypertension Studies
- S100 Proteins and Annexins
- Long-Term Effects of COVID-19
- Cardiovascular Disease and Adiposity
- Hormonal Regulation and Hypertension
- Cancer, Lipids, and Metabolism
- Cardiovascular Function and Risk Factors
- COVID-19 and healthcare impacts
- Biomarkers in Disease Mechanisms
- Cardiac Health and Mental Health
- Atherosclerosis and Cardiovascular Diseases
- Genetic Associations and Epidemiology
- Cytokine Signaling Pathways and Interactions
- Liver Disease Diagnosis and Treatment
- Nutrition, Genetics, and Disease
- Heart Rate Variability and Autonomic Control
- Acute Ischemic Stroke Management
- Neurological Disorders and Treatments
City Clinical Hospital
2016-2024
City Clinical Hospital No. 2
2023-2024
Central State Hospital
2024
Central State Medical Academy
2016-2023
Regional Public Health Care Institution "City Hospital No. 5, Barnaul"
2023
Clinical Hospital No. 8
2023
City Hospital
2021-2022
Kazan State Medical University
2018-2020
Lomonosov Moscow State University
2019
National Medical Research Center of Cardiology
2018
Aim . To analyze newly diagnosed diseases and features of the post-COVID course in patients after a coronavirus disease 2019 (COVID-19) within 12-month follow-up. Material methods A total 9364 consecutively hospitalized were included ACTIV registry. Enrollment began on June 29, 2020, was completed March 30, 2021, corresponding to first second waves pandemic. Demographic, clinical, laboratory data, computed tomography (CT) results, information about inhospital clinical complications COVID-19...
A prospective randomized observational study was conducted in cohorts of vaccinated and unvaccinated patients hospitalized one the Moscow hospitals diagnozed with COVID-19 period from 06.23.2021 to 01.05.2022. The purpose identify epidemiological features people present scientifically based data on need for vaccination its importance stopping epidemic process. Materials Methods . samples were studied comparison a number indicators: age, clinical condition at admission, presence concomitant...
Семейная гиперлипидемия (СГ) чаще выявляется у больных, поступивших в стационар с осложнениями атеросклероза.Целью данного исследования был анализ частоты встречаемости и особенностей течения острого коронарного синдрома (ОКС) молодых больных зависимости от наличия СГ.Из 1754 многоцентрового клинического наблюдательного проекта ОРАКУЛ II было отобрано 322, которых индексный эпизод обострения ИБС развился раннем возрасте (мужчины ≤55 лет, женщины ≤60 лет).Для диагностики СГ была использована...
Aim To evaluate the prognostic significance of left ventricular global function index (LV GFI) in patients with acute coronary syndrome (ACS) using echocardiography (EchoCG). Material and methods The LV GFI is an that integrates cavity volumes, stroke volume, myocardial volume. This study included 2169 ACS (1340 (61.8%) men) aged 64.1±12.6 years from two observational multicenter studies, ORACLE I II. 1800 (83 %) cases were associated increased concentrations injury markers, including 826...
Aim . To investigate on post-COVID period in patients of the Eurasian region. Material and methods A total 9364 consecutively hospitalized were included ACTIV registry. Enrollment began June 29, 2020, was completed March 30, 2021, corresponding to first second waves pandemic. Demographic, clinical, laboratory data, computed tomography (CT) results, information about inhospital clinical course complications COVID-19 during hospitalization extracted from electronic health records using a...
BACKGROUND. There is enough evidence of the negative impact excess weight on formation and progression res piratory pathology. Given continuing SARS-CoV-2 pandemic, it relevant to determine relationship between body mass index (BMI) clinical features novel coronavirus infection (NCI). AIM. To study effect BMI course acute SARS-COV-2 post-covid period. MATERIALS AND METHODS. AKTIV 2 are multicenter non-interventional real-world registers. The АКТИВ registry (n=6396) includes non-overlapping...
Aim. To identify the risk factors for bleeding of BARC scale 2-5 types in patients after acute coronary syndrome (ACS). Material and methods. The data 1502 from open multicenter study, ORACUL II, were used — 894 men (59,5%) 608 women (40,5%), mean age 65,7±12,9 years. Five hundred sixty (37,3%) had ACS with ST-segment elevation 942 (62,7%) without elevation. Bleeding was recorded 164 (10,9%), including index admission 39 (2,6%) patients, which severe (types 3-5) 0,5%, significant 1,7% 2-5)....
Aim . To analyze possible association of the risk adverse outcomes development in patients post acute coronary episode (ACS), with polymorphism gene TNF. Material and methods study, included, that were under observation 2 registry studies ORACLE I II (Exacerbation heart disease: logic-probability ways course prediction treatment optimization). In overall, 2012 ACS assessed. Mean age 64,7±12,69 y.o. There 1205 males (59,8%) 807 females (40,2%). 741 (36,8%) included ST elevation ACS, 1271...
The aim of the study was to analyze clinical features patients with premature acute coronary syndrome (ACS) in relation family history cardiovascular disease (CVD) and familial hypercholesterolemia (FH).Of 2832 included ORACUL 1 2 multicenter observational trials 512 pts who developed ACS (≤55 years for men, ≤60 women) had known LDL level were selected this study. Of these 297 positive (51 FH, 246 no FH), 215 negative history.Among there more women (31 vs 20.9 %), while among men (79.1 69...
The actual prevalence of genetic variants causing familial hypercholesterolemia (FH) in every population remains unknown. aim this work was to determine the spectrum pathogenic patients with acute coronary syndrome (ACS) and clinically diagnosed FH using targeted sequencing. We selected 38 ACS from sample 2,081 participants two multicenter observational studies (2004–2007; 2014–2016) who had a clinical diagnosis based on Dutch Lipid Clinic Network score Simon Broome criteria. men women...
Materials and methods: a prospective non-randomized pilot multicenter study of the informativeness clinical significance hemostasis laboratory tests in 1210 patients with COVID-19 disease course, including favorable unfavorable outcomes, was performed. Hemostasis assessed using clotting D-dimer concentration, thromboelastography (TEG) thrombodynamics (TD). Results: comparison parameters picture showed that 75% have pronounced activation plasma coagulation system upon admission to hospital....
Relevance. COVID-19 vaccination reduces mortality and the course of severe diseases. However, there is an insufficiency studies evaluating factors leading to infection among vaccinated individuals. Aim. Identification epidemiological features that distinguish cases disease in unvaccinated cohorts. Materials methods. The analysis incidence 1126 hospitalized patients period from 23.06.2021 01.05.2022 was carried out taking into account presence or absence against SARS-CoV-2 virus. Results. It...
Aim. To evaluate and compare the prognostic value of various scales on risk upper gastrointestinal bleeding (GIB) in patients with stable coronary artery disease (CAD) Russian population. Material methods. The study included CAD — participants REGATTA-1 prospective single-center registry. number points was assessed according to reference score 2015 European Society Cardiology (ESC), PRECISE-DAPT, ABC-HBR REACH scores, as well two scores REGATTA ORACUL score, originally developed for acute...
Background: The clinical phenotype of familial hypercholesterolemia (FH) combined with the classical genetic defects this disease increase risk coronary artery (CAD) in case a high level lipoprotein (a) (Lp(a)). Aim: To assess association hereditary disorders lipid metabolism Lp(a) an early manifestation CAD absence FH phenotype. Methods: We studied 81 patients premature (at age up to 55 years men and 60 women). was measured blood serum by immunoturbidimetric method. performed molecular...
Aim. To assess the possibility of familial hypercholesterolemia (FH) detection among patients with early coronary artery disease (CAD) in practice comparison data from different populations. Patients manifestations CAD are a promising group for identifying proband FH and subsequent cascade screening. The question remains open about sufficiency clinical criteria diagnosing this disease. Material methods. We examined 651 aged £55 years men £60 women. was diagnosed according to Dutch Lipid...
Aim . To study the lipid profile in hospitalized patients with coronavirus disease 2019 (COVID-19) depending on outcome of its acute phase according to AKTIV international registry. Material and methods The registry included men women over 18 years age a diagnosis COVID-19, who were treated hospital. A total 9364 registry, which 623 analyzed for levels cholesterol, low-density lipoprotein cholesterol (LDL-C) triglycerides days 1-2 hospitalization. level high-density (HDL-C) was calculated...
Aim. To validate a domestic scale for assessment risk of bleeding ORACUL (ОРАКУЛ) based on an independent sample patients with acute coronary syndrome (ACS). Materials and methods. External validation the score was carried out using database observational study RECORD-3 which comprised data from all hospitalized 1 month (march-april 2015) in 47 centers 37 cities 21 regions Russia. Total number included 2370, mean age 64.2±11.96 years, 821 (34.6%) had ST-elevation, other – non-ST elevation...
Aim To develop a model for evaluating the risk of stroke in patients after exacerbation ischemic heart disease who were admitted to hospitals included into vascular program.Materials and methods This study 1803 with acute coronary syndrome (ACS) from four institutions Moscow, Kazan, Astrakhan, Krasnodar where program was established. Mean age 64.9±12.78 years, 62,1 % them men. The followed up one year discharge hospital. External validation developed prognostic performed on cohort ACS...
Aim . To compare the diagnostic value of different bleeding risk scales in patients with acute coronary syndrome (ACS). Material and methods The study included 1502 ACS from observational, open-label, multicenter trial ORACUL II. mean age was 65,7±12,9 years. At follow-up visits (hospital discharge, 25, 90, 180 360 days index event), all cases were recorded a description characteristics, source, severity, treatment, classification according to BARC, TIMI, ISTH scales. Results. During period,...
Aim. To reveal the association of hereditary specifics inflammatory factors with adverse risk in atrial fibrillation (AF). Material and methods. Totally 258 patients studied (68,5±0,67 y. o.) nonvalvular AF, recording events as ischemic stroke, myocardial infarction, venous arterial thromboembolism. Mean follow-up was 455±11,71 days. Results. Factors that are independently associated stroke development not receiving anticoagulants (n=101), were allele C polymorphic marker rs2228145(А/С) gene...
Истинная распространенность генетических вариантов, стоящих за развитием семейной гиперхолестеринемии (СГХС), и характерных для каждой популяции, остается неизвестной. Целью работы было определение спектра патологических вариантов у больных острым коронарным синдромом (ОКС) с клинически диагностированной СГХС помощью таргетного секвенирования. Были отобраны 38 из 2081 пациентов двух многоцентровых наблюдательных исследований ОКС (2004–2007; 2014–2016 гг.) возрастом ≤ 55 лет (мужчины) 60...
BACKGROUND: The left ventricular global function index (LVGFI), determined using transthoracic echocardiography, is a simple clinical marker of dysfunction and has superior prognostic value to the standard ejection fraction-based assessment cardiac pump function. methodology for calculating this was proposed in 2019. Currently, factors that influence state functions are not examined.
 AIM: This study aimed assess association LVGFI with peculiarities daily blood pressure (BP) profile...