G. A. Bykova
A5084274695- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Respiratory and Cough-Related Research
- Asthma and respiratory diseases
- COVID-19 and healthcare impacts
- Pediatric health and respiratory diseases
- SARS-CoV-2 and COVID-19 Research
- Liver Disease Diagnosis and Treatment
- Human Health and Disease
- Healthcare Systems and Public Health
- Health and Well-being Studies
- Eosinophilic Esophagitis
- Urticaria and Related Conditions
- Inhalation and Respiratory Drug Delivery
- COVID-19 epidemiological studies
- Cardiovascular Disease and Adiposity
- COVID-19 and Mental Health
- Allergic Rhinitis and Sensitization
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
Perm State Medical Academy
2021-2025
Ural State Medical University
2023-2024
Regional Children's Hospital No1
2023
Aim. To study the clinical course specifics of coronavirus disease 2019 (COVID-19) and comorbid conditions in COVID-19 survivors 3, 6, 12 months after recovery Eurasian region according to AKTIV register. Material methods. The register was created at initiative Association Therapists. is divided into 2 parts: 1 2. currently includes 6300 patients, while — 2770. Patients diagnosed with receiving in- outpatient treatment have been anonymously included on registry. following 7 countries...
The international AKTIV register presents a detailed description of out- and inpatients with COVID-19 in the Eurasian region. It was found that hospitalized patients had more comorbidities. In addition, these were older there men than among outpatients. Among traditional risk factors, obesity hypertension significant negative effect on prognosis, which for 60 years age older. comorbidities, CVDs maximum this other type 2 1 diabetes, chronic kidney disease, obstructive pulmonary cancer anemia...
Aim. To assess the effectiveness of vaccination against Omicron and Delta variants according to international registry "Dynamics Analysis Comorbidities in SARS-CoV-2 Survivors" (AKTIV-4). Material methods. The AKTIV-4 included men women over 18 years age with a diagnosis coronavirus disease 2019 (COVID-19) (oropharyngeal nasopharyngeal swabs, antibody titers, typical computed tomography performance), undergoing hospital treatment. A total 3543 patients from 25 medical centers 7 countries...
The organizer of the registers “Dynamics analysis comorbidities in SARSCoV-2 survivors” (AKTIV) and “Analysis hospitalizations comorbid patients infected during second wave SARS-CoV-2 outbreak” (AKTIV 2) is Eurasian Association Therapists (EAT). Currently, there are no clinical registries region designed to collect analyze information on long-term outcomes COVID-19 survivors with conditions. aim register assess impact a novel coronavirus infection course chronic non-communicable diseases 3,...
Introduction . There is insufficiency of direct comparative studies genetically engineered biological drugs (GEBD) for severe bronchial asthma (SA) treatment in scientific databases. Aim To compare omalizumab and dupilumab effectiveness patients with allergic mixed SA real clinical practice. Materials methods The study included an component from regional registry Sverdlovsk region. data (n = 68) 27) treated 62) 33) were analyzed. Therapy was determined 12 months general group No. 1, 2 3...
Introduction . Severe asthma targeted therapy effectiveness depends on precise targeting of the selected drug to key link in pathogenesis. Therefore, severe phenotyping real clinical practice is relevant. Aim To determine main and allergological characteristics patients with establish important signs determined choice a for treatment. Materials methods The prospective retrospective study involved (n = 198) Sverdlovsk region registry receiving asthma. Considering picture, allergic,...
Aim. Study the impact of various combinations comorbid original diseases in patients infected with COVID-19 later on disease progression and outcomes new coronavirus infection. Materials methods. The ACTIV registry was created Eurasian Association Therapists initiative. 5,808 have been included registry: men women treated at hospital or home. ClinicalTrials.gov ID NCT04492384. Results. Most (oCDs). Polymorbidity assessed by way simple counting oCDs is an independent factor negative COVID-19....
Aim To study the effect of regular drug therapy for cardiovascular and other diseases preceding COVID-19 infection on severity outcome based data ACTIVE (Analysis dynamics Comorbidities in paTIents who surVived SARS-CoV-2 infEction) registry.Material methods The registry was created at initiative Eurasian Association Therapists. includes 5 808 male female patients diagnosed with treated a hospital or home due protection patients' privacy (data nasal throat smears; antibody titer; typical CT...
Aim . To analyze newly diagnosed diseases and features of the post-COVID course in patients after a coronavirus disease 2019 (COVID-19) within 12-month follow-up. Material methods A total 9364 consecutively hospitalized were included ACTIV registry. Enrollment began on June 29, 2020, was completed March 30, 2021, corresponding to first second waves pandemic. Demographic, clinical, laboratory data, computed tomography (CT) results, information about inhospital clinical complications COVID-19...
BACKGROUND: The complexity of choosing a genetically engineered biological drug for the treatment severe bronchial asthma is due to intersection disease endotypes and phenotypes. Mistakes in choice lead discontinuation and/or switching because insufficient effectiveness therapy. AIM: To determine reasons stopping targeted therapy patients with clinical practice. MATERIALS AND METHODS: Patients (n=116) from Sverdlovsk region register were divided into three groups: (1) continuous, (2)...
Aim . To investigate on post-COVID period in patients of the Eurasian region. Material and methods A total 9364 consecutively hospitalized were included ACTIV registry. Enrollment began June 29, 2020, was completed March 30, 2021, corresponding to first second waves pandemic. Demographic, clinical, laboratory data, computed tomography (CT) results, information about inhospital clinical course complications COVID-19 during hospitalization extracted from electronic health records using a...
BACKGROUND. There is enough evidence of the negative impact excess weight on formation and progression res piratory pathology. Given continuing SARS-CoV-2 pandemic, it relevant to determine relationship between body mass index (BMI) clinical features novel coronavirus infection (NCI). AIM. To study effect BMI course acute SARS-COV-2 post-covid period. MATERIALS AND METHODS. AKTIV 2 are multicenter non-interventional real-world registers. The АКТИВ registry (n=6396) includes non-overlapping...
Introduction. Biologics for severe asthma (SA) treatment are widely used in real clinical practice. But there very few direct comparative studies at the moment. Aim. To compare mepolizumab and dupilumab effectiveness patients with non-allergic eosinophilic SA practice using regional register of Sverdlovsk region. Materials methods. The data treated (n = 23) 19) were analyzed. Therapy was determined according to BARS patients’ proportion who achieved remission, dynamics ACT, AQLQ, FEV 1 ,...
Introduction . There is insufficient data on effectiveness and safety of targeted drugs aimed at T2 inflammation in real-life practice. Aim To evaluate benralizumab patients with T2-inflammatory airway diseases clinical practice to identify predictors a positive response therapy. Materials methods Patients' from Sverdlovsk region registry non-allergic eosinophilic (n = 32) mixed 6) severe asthma received were analyzed. Reduction proportion requiring systemic GCS good therapy according BARS...
Introduction . The “spot” effect of immunobiological drugs necessitates patients' selection based on pathogenetic mechanisms the disease to ensure therapy effectiveness. Aim To determine characteristics T2-asthma main phenotypes and develop an algorithm for selecting a first- second-line biologics. Materials methods Being retrospective prospective in nature research was directed at adult patients with severe asthma who received target were included registry Sverdlovsk region. Cluster...
With the narrow action of immunobiological drugs, it is necessary to understand pathogenetic mechanisms severe asthma (SA) in a particular patient. The aim work was demonstrate importance determining endotype and phenotype SA select targeted drug using example cases anti-IL5R treatment failure patients with allergic (ASA). Patients (n = 2) ASA onset childhood, identified causative allergens, high eosinophilia before start therapy are presented. use anti-IL5 benralizumab such permitted by...
Aim . To study the lipid profile in hospitalized patients with coronavirus disease 2019 (COVID-19) depending on outcome of its acute phase according to AKTIV international registry. Material and methods The registry included men women over 18 years age a diagnosis COVID-19, who were treated hospital. A total 9364 registry, which 623 analyzed for levels cholesterol, low-density lipoprotein cholesterol (LDL-C) triglycerides days 1-2 hospitalization. level high-density (HDL-C) was calculated...
Цель: Изучение особенностей клинического течения новой коронавирусной инфекции и влияния сопутствующих заболеваний на исход заболевания у госпитализированных больных с инфекцией SARS-CoV-2 в первую вторую волны пандемии. Методы результаты. Для оценки COVID-19 Евразийском регионе были созданы международные регистры АКТИВ 1 во время второй пандемии 2. Набор регистр проводили 29.06.20 по 29.10.20, набрано 5 397 пациентов. Прием пациентов учет 2 01.11.20 до 30.03.21, 665 больных. Результаты....
BACKGROUND: Hereditary angioedema is a rare autosomal dominant disease that can cause edema of skin and mucous membranes, including life-threatening localization, in pathogenesis which plasma kallikrein also important. The main therapy aim to achieve complete control over symptoms improve quality life. In Russia, the first available specialized drug for long-term prophylaxis lanadelumab blocking kallikrein.
 AIM: show principles medical care patients with hereditary Sverdlovsk region...