A5009364518- Cytokine Signaling Pathways and Interactions
- Biomarkers in Disease Mechanisms
- S100 Proteins and Annexins
- Cardiac Imaging and Diagnostics
- Hormonal Regulation and Hypertension
- Genetic Associations and Epidemiology
- Cardiovascular Disease and Adiposity
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Function and Risk Factors
- Atherosclerosis and Cardiovascular Diseases
- Acute Myocardial Infarction Research
- Lipoproteins and Cardiovascular Health
- Adipokines, Inflammation, and Metabolic Diseases
- Nutrition, Genetics, and Disease
- Machine Learning in Healthcare
- Retinal Imaging and Analysis
- Blood properties and coagulation
- Takotsubo Cardiomyopathy and Associated Phenomena
- Cardiac Health and Mental Health
- Chronic Kidney Disease and Diabetes
- Apelin-related biomedical research
- Artificial Intelligence in Healthcare
- Prion Diseases and Protein Misfolding
- Electrolyte and hormonal disorders
- Metabolomics and Mass Spectrometry Studies
City Clinical Hospital
2018-2021
Presidential Executive Office
2011
State Research Center of the Russian Federation
2010
AbstractThe article focuses on the application of Bayesian networks (BN) technique to problems personalized medicine. The simple (intuitive) algorithm BN optimization with respect number nodes using naive network topology is developed. This allows increase prediction quality and identify most important variables network. parallel program implementing has demonstrated good scalability an in computational cores number, it can be applied large patients database containing thousands variables....
Aim To evaluate the prognostic significance of left ventricular global function index (LV GFI) in patients with acute coronary syndrome (ACS) using echocardiography (EchoCG). Material and methods The LV GFI is an that integrates cavity volumes, stroke volume, myocardial volume. This study included 2169 ACS (1340 (61.8%) men) aged 64.1±12.6 years from two observational multicenter studies, ORACLE I II. 1800 (83 %) cases were associated increased concentrations injury markers, including 826...
Aim . To analyze possible association of the risk adverse outcomes development in patients post acute coronary episode (ACS), with polymorphism gene TNF. Material and methods study, included, that were under observation 2 registry studies ORACLE I II (Exacerbation heart disease: logic-probability ways course prediction treatment optimization). In overall, 2012 ACS assessed. Mean age 64,7±12,69 y.o. There 1205 males (59,8%) 807 females (40,2%). 741 (36,8%) included ST elevation ACS, 1271...
The aim of the study was to analyze clinical features patients with premature acute coronary syndrome (ACS) in relation family history cardiovascular disease (CVD) and familial hypercholesterolemia (FH).Of 2832 included ORACUL 1 2 multicenter observational trials 512 pts who developed ACS (≤55 years for men, ≤60 women) had known LDL level were selected this study. Of these 297 positive (51 FH, 246 no FH), 215 negative history.Among there more women (31 vs 20.9 %), while among men (79.1 69...
The aim of this study was to investigate an association polymorphic markers G(-308)A TNF gene and Thr26Asn LTA with the frequency poor outcomes in patients history acute coronary syndrome.Methods. A total 1145 admitted cardiological hospitals Moscow, St. Petersburg, Kazan, Chelyabinsk, Perm, Stavropol, Rostov-on-Don ischemic heart disease exacerbation were examined. maximum follow up time 3.2 years. identification marker allele carried out by hybridization-fluorescent analysis using...
Objective: The purpose of our work was to analyze the possible association clinical and genetic factors with development strokes in patients coronary heart disease. Design method: We included study 1193 acute syndrome (63,2% men, mean age 61,1 ± 0,34 yaers). 81,5% had essential hypertension, 14,6% - diabetes, 38,5% were smokers, 16,4% anamnesis atrial fibrillation. Follow up started on day 10 stable state after index event. Inclusion into performed 2004–2007. Mean duration follow 664,9 days,...
Purpose: to analyze possible associations of clinical and genetic factors with development ischemic stroke after exacerbation heart disease (IHD). Materials methods: RAe Russian multicenter study aimed at assessment risk unfavorable outcomes IHD "Exacerbation IHD: logical probabilistic ways course prognostication for optimization treatment” (meaning Cyrillic acronym - oracle) was conducted in 16 centers 7 cities Russia. We included into the 1 208 patients unstable angina ST-elevation or...
Abstract Background Genetic predisposition makes a considerable contribution to premature acute coronary syndrome (ACS) development. Tumour necrosis factor (TNF) is an important proinflammatory cytokine influencing intravascular inflammation. Annexin A2 (ANXA2) endogenous PCSK9 inhibitor. Higher LDL level associated with AA genotype of ANXA2 gene SNP rs17845226. Aim The aim the study was elucidate association TNF and polymorphism angiography features outcome in patients (pts) early ACS....
BACKGROUND: Genetic factors are essential for the pathogenesis of coronary heart disease (CHD). This study presents role genetic in a prematurely developing males under 55 years old and females 60 old. Additionally, risk may also be significant CHD development other age groups although specific differ.
 AIM: The work aimed to analyze prevalence hereditary different patients with disease.
 MATERIALS AND METHODS: was conducted as part analysis data from two observational multicenter...