Н. В. Ларева
A5065818651- Eosinophilic Esophagitis
- Long-Term Effects of COVID-19
- Helicobacter pylori-related gastroenterology studies
- COVID-19 Clinical Research Studies
- Cardiovascular Disease and Adiposity
- Healthcare Systems and Public Health
- Gastroesophageal reflux and treatments
- Human Health and Disease
- COVID-19 and healthcare impacts
- Fatty Acid Research and Health
- Cardiovascular Function and Risk Factors
- Galectins and Cancer Biology
- Influenza Virus Research Studies
- Biomarkers in Disease Mechanisms
- Inflammatory mediators and NSAID effects
- Cardiovascular Health and Disease Prevention
- Microscopic Colitis
- Eicosanoids and Hypertension Pharmacology
- Blood Pressure and Hypertension Studies
- Liver Disease Diagnosis and Treatment
- Esophageal and GI Pathology
- GDF15 and Related Biomarkers
- Diabetes Treatment and Management
- Antiplatelet Therapy and Cardiovascular Diseases
- Esophageal Cancer Research and Treatment
Chita State Academy of Medicine
2013-2025
Ministry of Health of the Russian Federation
2020-2023
Aim. To study the clinical course specifics of coronavirus disease 2019 (COVID-19) and comorbid conditions in COVID-19 survivors 3, 6, 12 months after recovery Eurasian region according to AKTIV register. Material methods. The register was created at initiative Association Therapists. is divided into 2 parts: 1 2. currently includes 6300 patients, while — 2770. Patients diagnosed with receiving in- outpatient treatment have been anonymously included on registry. following 7 countries...
The international AKTIV register presents a detailed description of out- and inpatients with COVID-19 in the Eurasian region. It was found that hospitalized patients had more comorbidities. In addition, these were older there men than among outpatients. Among traditional risk factors, obesity hypertension significant negative effect on prognosis, which for 60 years age older. comorbidities, CVDs maximum this other type 2 1 diabetes, chronic kidney disease, obstructive pulmonary cancer anemia...
Objective: To analyze literature data and compare the common pathways of inflammation in inflammatory bowel diseases (IBD) atherosclerosis with focus on effects proinflammatory cytokines both pathologies, as well from perspective potential role gene polymorphism pathophysiology IBD patients. Main provisions: In IBD, a serum cytokine profile initiates supports chronic inflammation. The main immunological mechanisms are mediated by hyperproduction cytokines, such tumor necrosis factor α...
Helicobacter pylori (HP) is one of the most common infections and recognized as a gastric pathogen in humans, leading to development gastritis all infected individuals. The etiological role HP formation peptic ulcer (PU) cancer (GC) has been noted. prevalence differs different regions, ethnic, social age groups. article summarizes publications on frequency infection countries, changes epidemiological situation world recent years, noted decrease positivity Japan, Korea, China, Australia. Risk...
The organizer of the registers “Dynamics analysis comorbidities in SARSCoV-2 survivors” (AKTIV) and “Analysis hospitalizations comorbid patients infected during second wave SARS-CoV-2 outbreak” (AKTIV 2) is Eurasian Association Therapists (EAT). Currently, there are no clinical registries region designed to collect analyze information on long-term outcomes COVID-19 survivors with conditions. aim register assess impact a novel coronavirus infection course chronic non-communicable diseases 3,...
Aim. Study the impact of various combinations comorbid original diseases in patients infected with COVID-19 later on disease progression and outcomes new coronavirus infection. Materials methods. The ACTIV registry was created Eurasian Association Therapists initiative. 5,808 have been included registry: men women treated at hospital or home. ClinicalTrials.gov ID NCT04492384. Results. Most (oCDs). Polymorbidity assessed by way simple counting oCDs is an independent factor negative COVID-19....
Aim To study the effect of regular drug therapy for cardiovascular and other diseases preceding COVID-19 infection on severity outcome based data ACTIVE (Analysis dynamics Comorbidities in paTIents who surVived SARS-CoV-2 infEction) registry.Material methods The registry was created at initiative Eurasian Association Therapists. includes 5 808 male female patients diagnosed with treated a hospital or home due protection patients' privacy (data nasal throat smears; antibody titer; typical CT...
Aim . To analyze newly diagnosed diseases and features of the post-COVID course in patients after a coronavirus disease 2019 (COVID-19) within 12-month follow-up. Material methods A total 9364 consecutively hospitalized were included ACTIV registry. Enrollment began on June 29, 2020, was completed March 30, 2021, corresponding to first second waves pandemic. Demographic, clinical, laboratory data, computed tomography (CT) results, information about inhospital clinical complications COVID-19...
Antidepressants (ADs) include drugs of various pharmacological groups, which are mainly used for the treatment mental disorders (major depressive disorder, obsessive-compulsive social phobia, panic generalized anxiety post-traumatic stress disorder), chronic pain and addiction diseases. Chronic use ADs can lead to development cardiotoxic adverse drug reactions (ADRs). The most important AD-induced ADRs prolongation QT interval, ventricular tachycardia "pirouette" type (Torsades de Pointes -...
The members of the working group confirmed no conflict interest or financial support.
Gestational diabetes mellitus (GDM) and its consequences for the mother child represent a serious not only medical, but also an economic problem. The urgency of studying this problem lies in fact that number pregnant women suffering from disease is progressively increasing. aim study was to risk factors features course pregnancy childbirth with gestational mellitus, as well improve methods diagnosing predicting development diabetic fetopathy (DF). work carried out 3 stages: 1 — prospective...
In connection with the widespread use of anticonvulsants (antiepileptic drugs – AEDs) in psychiatric and neurological practice need for their long-term to treat a wide range mental disorders diseases, question safety profile, including assessment risk developing life-threatening conditions adverse reactions (ADRs), becomes relevant. this regard, from position personalized medicine, it is critical develop an interdisciplinary approach participation doctors various specialties new strategy...
Aim . To investigate on post-COVID period in patients of the Eurasian region. Material and methods A total 9364 consecutively hospitalized were included ACTIV registry. Enrollment began June 29, 2020, was completed March 30, 2021, corresponding to first second waves pandemic. Demographic, clinical, laboratory data, computed tomography (CT) results, information about inhospital clinical course complications COVID-19 during hospitalization extracted from electronic health records using a...
BACKGROUND. There is enough evidence of the negative impact excess weight on formation and progression res piratory pathology. Given continuing SARS-CoV-2 pandemic, it relevant to determine relationship between body mass index (BMI) clinical features novel coronavirus infection (NCI). AIM. To study effect BMI course acute SARS-COV-2 post-covid period. MATERIALS AND METHODS. AKTIV 2 are multicenter non-interventional real-world registers. The АКТИВ registry (n=6396) includes non-overlapping...
The erosive ulcerous affections of gastrointestinal tract in patients with cardiovascular diseases occur frequently and are conditioned by both ischemia organs digestion against the background reduced cardiac output intake low doses acetylsalicylic acid combined anti-coagulants. bleeding can be first only manifestation gastroduodenal pathology. treatment prevention aspirin-induced gastropathy provides for implementation eradication Helicobacter pylori infection, application cyto-protectors...
Background: Nitric oxide (NO) is an important autocrine and paracrine signaling molecule that plays a crucial role in cardiovascular physiology pathology regulation. NO involved regulation of cerebral extra cranial blood flow arterial diameters. Reduced bioavailability the endothelium precursor for impaired vasodilation hypertension (AH). Furthermore, nociceptive processing. A NO-induced biphasic response with immediate delayed headache typical chronic tension-type headaches (TTH) humans....
Резюме.В статье представлены данные по распространенности гастроэзофагеальной рефлюксной болезни (ГЭРБ
The mechanisms of the gastroesophageal reflux disease (GERD) development and its complications are analyzed on tissue cell levels. That’s why studying polymorphism interleukin (IL) genes is important. Genotypes IL1β-511Т/Т, IL1β31С/С IL1RN2/2 (receptor antagonist IL1) associate with high risk complicated course GERD disease. Researching pro-inflammatory cytokines patients having changes in gastric mucosa it was determined that genotype IL1β-511Т/Т associated deeper local level IL1β....
Summary. Thirty three medical records and postmortem examination reports of patients died from influenza A virus (H1N1sw2009) in October November, 2009, the Transbaikal Territory were analyzed. The divided into two groups. first group consisted 22 with obesity second 11 normal body weight. There was no difference between groups age, gender structure, duration disease. Causes death pneumonia progressive respiratory failure. rate acute distress syndrome similar both Thrombosis various...
В статье приведены особенности организации медицинской помощи и интенсивной терапии больным с осложненными формами гриппа A/H1N1/09 сезонного в Забайкальском крае осенью 2009 года.
Aim . To identify genetic predictors of diastolic dysfunction and signs endothelial in relation to indicators left ventricular myocardial deformity patients with hypertension. Material methods The study included 74 (38 women 36 men) hypertension 1-2 stages observed the cardiology department Road clinical hospital at Chita II station. mean age was 32±9.4 years. Circulating cells (CEC) were determined by flow cytometry BT 5000 device antibodies CD146+, CD45. Besides, 7AAD ion dye used detect...