А. С. Благонравова
A5071679410- Folate and B Vitamins Research
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Metabolism and Genetic Disorders
- Gut microbiota and health
- COVID-19 and healthcare impacts
- Genetic Associations and Epidemiology
- Human Health and Disease
- Healthcare Systems and Public Health
- Tryptophan and brain disorders
- Amino Acid Enzymes and Metabolism
- Bipolar Disorder and Treatment
- Diet and metabolism studies
- SARS-CoV-2 and COVID-19 Research
- Child Nutrition and Feeding Issues
- Peroxisome Proliferator-Activated Receptors
- Alcoholism and Thiamine Deficiency
- Respiratory viral infections research
- Pediatric health and respiratory diseases
- Viral gastroenteritis research and epidemiology
- Autism Spectrum Disorder Research
- Infant Health and Development
- Neurological and metabolic disorders
- COVID-19 diagnosis using AI
- Yersinia bacterium, plague, ectoparasites research
Perm State Medical Academy
2024
Privolzhsky Research Medical University
2013-2023
Ministry of Health of the Russian Federation
2020
Evidence Based Research (United States)
2020
Aim. To study the clinical course specifics of coronavirus disease 2019 (COVID-19) and comorbid conditions in COVID-19 survivors 3, 6, 12 months after recovery Eurasian region according to AKTIV register. Material methods. The register was created at initiative Association Therapists. is divided into 2 parts: 1 2. currently includes 6300 patients, while — 2770. Patients diagnosed with receiving in- outpatient treatment have been anonymously included on registry. following 7 countries...
The international AKTIV register presents a detailed description of out- and inpatients with COVID-19 in the Eurasian region. It was found that hospitalized patients had more comorbidities. In addition, these were older there men than among outpatients. Among traditional risk factors, obesity hypertension significant negative effect on prognosis, which for 60 years age older. comorbidities, CVDs maximum this other type 2 1 diabetes, chronic kidney disease, obstructive pulmonary cancer anemia...
The organizer of the registers “Dynamics analysis comorbidities in SARSCoV-2 survivors” (AKTIV) and “Analysis hospitalizations comorbid patients infected during second wave SARS-CoV-2 outbreak” (AKTIV 2) is Eurasian Association Therapists (EAT). Currently, there are no clinical registries region designed to collect analyze information on long-term outcomes COVID-19 survivors with conditions. aim register assess impact a novel coronavirus infection course chronic non-communicable diseases 3,...
Background Prediction of the severity COVID-19 at its onset is important for providing adequate and timely management to reduce mortality. Objective To study prognostic value damage parameters cytokines as predictors using an extensive immunologic profiling unbiased artificial intelligence methods. Methods Sixty hospitalized patients (30 moderate 30 severe) 17 healthy controls were included in study. The indicators high mobility group box 1 (HMGB1), lactate dehydrogenase (LDH), aspartate...
Aim. Study the impact of various combinations comorbid original diseases in patients infected with COVID-19 later on disease progression and outcomes new coronavirus infection. Materials methods. The ACTIV registry was created Eurasian Association Therapists initiative. 5,808 have been included registry: men women treated at hospital or home. ClinicalTrials.gov ID NCT04492384. Results. Most (oCDs). Polymorbidity assessed by way simple counting oCDs is an independent factor negative COVID-19....
Aim To study the effect of regular drug therapy for cardiovascular and other diseases preceding COVID-19 infection on severity outcome based data ACTIVE (Analysis dynamics Comorbidities in paTIents who surVived SARS-CoV-2 infEction) registry.Material methods The registry was created at initiative Eurasian Association Therapists. includes 5 808 male female patients diagnosed with treated a hospital or home due protection patients' privacy (data nasal throat smears; antibody titer; typical CT...
Abstract We provide an overview of the recent achievements in psychiatric genetics research Russian Federation and present genotype-phenotype, population, epigenetic, cytogenetic, functional, ENIGMA, pharmacogenetic studies, with emphasis on genome-wide association studies. The genetic backgrounds mental illnesses polyethnic multicultural population are still understudied. Furthermore, genetic, genomic, data from not adequately represented international scientific literature, currently...
At least 50% of factors predisposing to alcohol dependence (AD) are genetic and women affected with this disorder present more psychiatric comorbidities, probably indicating different involved. We aimed run a genome-wide association study (GWAS) followed by bioinformatic functional annotation associated genomic regions in patients AD eight related clinical measures. A significant rs220677 (p-value = 1.33 × 10−8 calculated the Yates-corrected χ2 test under assumption dominant inheritance) was...
Aim . To analyze newly diagnosed diseases and features of the post-COVID course in patients after a coronavirus disease 2019 (COVID-19) within 12-month follow-up. Material methods A total 9364 consecutively hospitalized were included ACTIV registry. Enrollment began on June 29, 2020, was completed March 30, 2021, corresponding to first second waves pandemic. Demographic, clinical, laboratory data, computed tomography (CT) results, information about inhospital clinical complications COVID-19...
On the basis of literature data and results own research in article describes features epidemiology combined natural focal infections, their distribution Russian Federation, pathogenesis clinical to suit different combinations pathogen agents. The on mixed infection ticks by agents various combinations, as well polyetiology infected reservoir hosts Showing variants infections humans caused associations microorganisms, including up five assiociants, manifestations Based original developed a...
Currently, oxidative stress as part of the pathogenesis schizophrenia attracts much attention. In this regard, it becomes relevant to assess level redox imbalance in patients with schizophrenia, its impact on existing symptoms and possibility treatment. The antioxidant N-acetylcysteine is one potential drugs that affects stress.To study possibilities use schizophrenia.The included 20 diagnosed paranoid disease duration less than 3 years, randomly assigned main group (taking at a dose 2000 mg...
Aim . To investigate on post-COVID period in patients of the Eurasian region. Material and methods A total 9364 consecutively hospitalized were included ACTIV registry. Enrollment began June 29, 2020, was completed March 30, 2021, corresponding to first second waves pandemic. Demographic, clinical, laboratory data, computed tomography (CT) results, information about inhospital clinical course complications COVID-19 during hospitalization extracted from electronic health records using a...
COVID-19 is a severe infection with high mortality. The concept of the disease has been shaped to greater extent on basis large registers from USA, Spain, Italy, and China. However, there no information characteristics in Caucasian patients.Therefore, we created an international register estimated capacity 5,000 patients — Dynamics Analysis Comorbidities SARS-CoV-2 Survivors (AKTIV SARS-CoV-2), which brought together professionals Russian Federation, Republic Armenia, Kazakhstan, Kyrgyz...
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A wide range of studies have demonstrated that hyperhomocysteinemia is associated with the risk schizophrenia, but currently available assumptions about direct involvement homocysteine (Hcy) in pathogenesis schizophrenia are hypothetical. It possible vivo Hcy only a marker folate metabolism disturbances (which involved methylation processes) and not pathogenetic factor per se. Only one study has been conducted which associations oxidative stress (oxidative damage to protein lipids) found, it...
BACKGROUND. There is enough evidence of the negative impact excess weight on formation and progression res piratory pathology. Given continuing SARS-CoV-2 pandemic, it relevant to determine relationship between body mass index (BMI) clinical features novel coronavirus infection (NCI). AIM. To study effect BMI course acute SARS-COV-2 post-covid period. MATERIALS AND METHODS. AKTIV 2 are multicenter non-interventional real-world registers. The АКТИВ registry (n=6396) includes non-overlapping...
ЖУРНАЛ ИНФЕКТОЛОГИИ
The SARS-CoV-2 pandemic is a big challenge for humanity. COVID-19 severity differs significantly from patient to patient, and it important study the factors protecting severe forms of disease. Respiratory microbiota may influence patient's susceptibility infection disease due its ability modulate immune system response host organism. This data article describes microbiome dataset upper respiratory tract positive patients Russia. reports microbial community profile 335 human nasopharyngeal...
The aim of the investigation is to study carriage alleles folate cycle mTHFR677C>T polymorphism and assess cognitive function dynamics in course augmented antipsychotic therapy schizophrenic patients carrying defective mTHFR677T allele.Materials Methods.129 with schizophrenia underwent molecular diagnosing 677C>T mTHFR metabolism gene using PCR method allele-specific primers following on-line detection.of them 18 T allele received by folates.The were tested a standard battery tests before...
The first part of the literature review on role intestinal microbiota dysbiosis in pathogenesis autism spectrum disorders (ASD) includes recent data published features quantitative and qualitative composition patients with autism. It was shown that an excessive presence Clostridium detected ASD, evidence presented showing possible participation these bacteria development symptoms. Contradictory research results increase a number other pathogenic and, conversely, decrease necessary to...