A5021781906- HIV, Drug Use, Sexual Risk
- HIV/AIDS Research and Interventions
- Substance Abuse Treatment and Outcomes
- Opioid Use Disorder Treatment
- Treatment of Major Depression
- HIV Research and Treatment
- Neurotransmitter Receptor Influence on Behavior
- Liver Disease Diagnosis and Treatment
- Tryptophan and brain disorders
- Alcohol Consumption and Health Effects
- HIV-related health complications and treatments
- Adolescent Sexual and Reproductive Health
- Alcoholism and Thiamine Deficiency
- Sex work and related issues
- Gut microbiota and health
- Cannabis and Cannabinoid Research
- Schizophrenia research and treatment
- Mental Health Treatment and Access
- Bipolar Disorder and Treatment
- Homelessness and Social Issues
- Attention Deficit Hyperactivity Disorder
- Neuroscience and Neuropharmacology Research
- Sleep and related disorders
- Pain Management and Placebo Effect
- Psychedelics and Drug Studies
First Pavlov State Medical University of St. Petersburg
2016-2025
St.Petersburg V.M.Bekhterev Psychoneurological Research Institute
2016-2025
Research Medical Center
2021-2025
Ministry of Health of the Russian Federation
2015-2023
Pavlov Institute of Physiology of the Russian Academy of Sciences
2023
Tulane University
2023
Hvidovre Hospital
2020
City College of New York
2020
Copenhagen University Hospital
2020
Rhode Island Department of Behavioral Healthcare, Developmental Disabilities and Hospitals
2016
Alcohol abuse has deleterious effects on human health by disrupting the functions of many organs and systems. Gut microbiota been implicated in pathogenesis alcohol-related liver diseases, with its composition manifesting expressed dysbiosis patients suffering from alcoholic dependence. Due to inherent plasticity, gut is an important target for prevention treatment these diseases. Identification impact alcohol associated psychiatric symptoms community structure confounded dysfunction. In...
Background: Two recent large genetic studies in the US population have reported association between variation γ-amino butyric acid α2 receptor subtype (GABRA2) and risk for alcohol dependence. The goal of this study was to test whether GABRA2 is associated with dependence a sample Russian alcohol-dependent men. Methods: A total 113 men 100 male control subjects were recruited St. Petersburg genotyped seven single-nucleotide polymorphisms (SNPs) using real-time PCR (TaqMan). Six SNPs located...
<h3>Context</h3>Sustained-release naltrexone implants may improve outcomes of nonagonist treatment opioid addiction.<h3>Objective</h3>To compare implants, oral hydrochloride, and nonmedication treatment.<h3>Design</h3>Six-month double-blind, double-dummy, randomized trial.<h3>Setting</h3>Addiction programs in St Petersburg, Russia.<h3>Participants</h3>Three hundred six opioid-addicted patients recently undergoing detoxification.<h3>Interventions</h3>Biweekly counseling 1 the following 3...
Abstract Aims To describe drug use and safety with intramuscular injectable extended‐release naltrexone ( XR ‐ NTX ) in opioid dependence during a 1‐year open‐label extension phase. Design Following 6 months of randomized, double‐blind, placebo (PBO)‐controlled injections given every 28 days, patients receiving 380 mg continued PBO were switched to , monthly individual counseling, for further year. Setting Thirteen clinical sites R ussia. Participants Adult opioid‐dependent outpatients....
Highlights•Clinical and research NIBS operations are important in some cases critical to continue through the COVID-19 pandemic.•We provide a framework for maintaining their safety during future outbreaks.•Guidelines good practices managing reopening clinics laboratories presented.•Remotely supervised tDCS provides opportunity clinical treatments patients at home while staff offsite.•Onsite brain stimulation, such as TMS, can proceed when implementing workflows ensuring related...
We examined 13 single nucleotide polymorphisms (SNPs) spanning the coding region of µ-opioid receptor gene (OPRM1), among 382 European Americans (EAs) affected with substance dependence [alcohol (AD) and/or drug (DD)] and 338 EA healthy controls. These SNPs delineated two haplotype blocks. Genotype distributions for all were in Hardy–Weinberg equilibrium (HWE) controls, but cases, four Block I three II showed deviation from HWE. Significant differences found between cases controls allele...
Abstract A prior study found that one ketamine-assisted psychotherapy session was significantly more effective than active placebo in promoting abstinence (Krupitsky et al. 2002). In this of the efficacy single versus repeated sessions people with heroin dependence, 59 detoxified inpatients dependence received a ketamineassisted (KPT) to their discharge from an addiction treatment hospital, and were then randomized into two groups. Participants first group counseling followed by KPT...
Background: Benzodiazepines are the standard pharmacotherapies for ethanol detoxification, but concerns about their abuse potential and negative effects upon transition to alcohol abstinence drive search new treatments. Glutamatergic activation glutamate receptor up‐regulation contribute dependence withdrawal. This study compared 3 antiglutamatergic strategies detoxification with placebo benzodiazepine, diazepam: release inhibitor, lamotrigine; N ‐methyl‐ d ‐aspartate antagonist, memantine;...
Objective: Ethanol blocks N -methyl- d -aspartic acid (NMDA) glutamate receptors. Increased NMDA receptor function may contribute to motivational disturbances that alcoholism. The authors assessed whether the antagonist memantine reduces cue-induced alcohol craving and produces ethanol-like subjective effects. Method: Thirty-eight alcohol-dependent inpatients participated in three daylong testing sessions a randomized order under double-blind conditions. On each test day, subjects received...
A placebo-controlled study of 100 outpatients with mixed heroin-amphetamine addiction showed that implanted naltrexone, designed to block opiate effects for 8–10 weeks, led 52% patients remaining in treatment and 38% having urine samples free both drugs at 10 compared 28% 16% drug the placebo implant. Use other substances, such as alcohol, did not increase.
With HIV prevalence estimated at 20% among female injecting drug users (IDUs) in St. Petersburg, Russia, there is a critical need to address the risks of this at-risk population. This study characterized associated with use and sex behaviors assessed initial feasibility efficacy an adapted Woman-Focused intervention, Women's CoOp, relative Nutrition control reduce risk IDUs inpatient detoxification treatment setting. Women (N = 100) were randomized into one two one-hour long intervention...
Background: Naltrexone is a μ-opioid receptor antagonist that blocks opioid effects. Craving, depression, anxiety, and anhedonia are common among dependent individuals concerns have been raised naltrexone increases them due to blocking endogenous opioids. Here, we present data address these concerns. Objective: Assess the relationship between affective responses treatment. Methods: Opioid patients (N = 306) were enrolled in three cell (102ss/cell) randomized, double blind, dummy,...
Positive Psychology, the study of "positive" factors or strengths and evidence-based interventions to increase them, is a rapidly developing field that beginning be applied HIV care. Proactive coping spirituality are two positive characteristics have been examined in multiple chronic serious health conditions. In present study, lost-to-care (LTCs; did not attend treatment for ≥12 months; n = 120) engaged-in-care clinic patients (EICs; attended months adherent with antiretrovirals; Leningrad...