A5030170581- Neuroscience and Music Perception
- Advanced Neuroimaging Techniques and Applications
- Transcranial Magnetic Stimulation Studies
- Acute Ischemic Stroke Management
- Stroke Rehabilitation and Recovery
- Neurobiology of Language and Bilingualism
- Functional Brain Connectivity Studies
- Motor Control and Adaptation
- Hemispheric Asymmetry in Neuroscience
- Multisensory perception and integration
- Advanced MRI Techniques and Applications
- Diverse Music Education Insights
- Hearing Loss and Rehabilitation
- Music Therapy and Health
- EEG and Brain-Computer Interfaces
- Action Observation and Synchronization
- Cerebrovascular and Carotid Artery Diseases
- Neural dynamics and brain function
- Neural and Behavioral Psychology Studies
- Intracerebral and Subarachnoid Hemorrhage Research
- Autism Spectrum Disorder Research
- Epilepsy research and treatment
- Muscle activation and electromyography studies
- Vestibular and auditory disorders
- Cerebral Palsy and Movement Disorders
Baystate Medical Center
2020-2025
University of Massachusetts Chan Medical School
2020-2025
University of Massachusetts Amherst
2020-2025
Baystate Health
2020-2025
Beth Israel Deaconess Medical Center
2015-2024
Harvard University
2015-2024
Wesleyan University
2024
Amherst College
2023
Hadassah Medical Center
2003-2022
Pioneer (United States)
2021
From an early age, musicians learn complex motor and auditory skills (e.g., the translation of visually perceived musical symbols into commands with simultaneous monitoring output), which they practice extensively from childhood throughout their entire careers. Using a voxel-by-voxel morphometric technique, we found gray matter volume differences in motor, auditory, visual-spatial brain regions when comparing professional (keyboard players) matched group amateur non-musicians. Although some...
Abstract Objective To determine whether prespecified baseline magnetic resonance imaging (MRI) profiles can identify stroke patients who have a robust clinical response after early reperfusion when treated 3 to 6 hours symptom onset. Methods We conducted prospective, multicenter study of 74 consecutive admitted academic centers in North America and Europe. An MRI scan was obtained immediately before treatment with intravenous tissue plasminogen activator Baseline were used categorize into...
The human brain has the remarkable capacity to alter in response environmental demands. Training-induced structural changes have been demonstrated healthy adult brain. However, no study yet directly related behavioral developing brain, addressing question of whether differences seen adults (comparing experts with matched controls) are a product “nature” (via biological predispositions) or “nurture” early training). Long-term instrumental music training is an intense, multisensory, and motor...
Certain human talents, such as musical ability, have been associated with left-right differences in brain structure and function. In vivo magnetic resonance morphometry of the musicians was used to measure anatomical asymmetry planum temporale, a area containing auditory association cortex previously shown be marker structural functional asymmetry. Musicians perfect pitch revealed stronger leftward temporale than nonmusicians or without pitch. The results indicate that outstanding ability is...
Identifying tissue at risk for infarction is important in deciding which patients would benefit most from potentially harmful therapies and provides a way to evaluate newer with regard the amount of ischemic salvaged.To operationally define characterize cerebral stroke progression.We retrospectively selected 25 an acute onset hemispheric our database who had undergone combination two diffusion-weighted MRI studies perfusion-weighted study. We applied logistic regression model using maps...
The discovery of audiovisual mirror neurons in monkeys gave rise to the hypothesis that premotor areas are inherently involved not only when observing actions but also listening action-related sound. However, whole-brain functional formation underlying such “action–listening” is fully understood. In addition, previous studies humans have focused mostly on relatively simple and overexperienced everyday actions, as hand clapping or door knocking. Here we used magnetic resonance imaging ask...
Abstract We aimed to determine the frequency and time course of enlargement ischemic cerebral lesions following human stroke study effect state perfusion on lesion enlargement. Acute volumes were measured diffusion‐weighted magnetic resonance images compared with T2‐weighted at 7 days or later. Forty‐four measurements performed between 2 53 hours after onset in 28 patients. Thirteen patients also had imaging performed. In 12 (43%) initial volume increased by 20% more. The number studies...
Motor recovery after stroke depends on the integrity of ipsilesional motor circuits and interactions between contralesional hemispheres. In this sham-controlled randomized trial, we investigated whether noninvasive modulation regional excitability bilateral cortices in combination with physical occupational therapy improves outcome stroke.Twenty chronic patients were randomly assigned to receive 5 consecutive sessions either 1) bihemispheric transcranial direct current stimulation (tDCS)...
Diffusion-weighted MRI can rapidly detect acute cerebral ischemic injury as hyperintense signal changes, reflecting a decline in the apparent diffusion coefficient (ADC) of water through brain parenchyma, whereas ADC is elevated chronic stage because increased extracellular content. To determine time course these we analyzed 157 diffusion-weighted studies performed at varying points from initial event 101 patients. Data were expressed relative (rADC), ratio lesion to control regions...
Abstract Diffusion‐weighted magnetic resonance imaging detects ischemic injury within minutes after onset, and has been used to demonstrate drug efficacy in animal models of stroke. In 50 patients diagnosed with acute stroke ( < 24‐hour duration) the middle cerebral artery territory, lesion volume was measured by diffusion‐weighted imaging. Thirty‐four also had volumes T2‐weighted chronically (median time, 7.5 weeks; mean, 15.9 weeks). Clinical severity National Institutes Health Stroke...
Research has revealed structural and functional differences in the brains of adult instrumental musicians compared to those matched nonmusician controls, with intensity/duration training practice being important predictors these differences. Nevertheless, differential contributions nature nurture are not yet clear. The musician-nonmusician comparison is an ideal model for examining whether and, if so, where such brain plasticity occurs, because acquire continuously a variety complex motor,...
Recent studies in humans and nonhuman primates have shown that the functional organization of human sensorimotor cortex changes following sensory stimulation or acquisition motor skills. It is unknown whether plasticity response to new skills continued performance complicated bimanual movements for years associated with structural cortex. Professional musicians, especially keyboard string players, are a prototypical group investigating these brain. Using magnetic resonance images, we...
Recovery from aphasia can be achieved through recruitment of either perilesional brain regions in the affected hemisphere or homologous language nonlesional hemisphere. For patients with large left-hemisphere lesions, recovery right may only possible path. The right-hemisphere most likely to play a role this process are superior temporal lobe (important for auditory feedback control), premotor regions/posterior inferior frontal gyrus planning and sequencing motor actions auditory-motor...
Motor impairment after stroke has been related to infarct size, location, and integrity of motor tracts. To determine the value diffusion tensor imaging (DTI) as a predictor outcome its role structural surrogate marker in chronic stroke, we tested correlations between DTI-derived measures tract integrity.Thirty-five patients with varying degrees recovery underwent DTI assessments. Fibers originating from precentral gyrus were traced separated into pyramidal (PT) alternate fibers (aMF)....
In this study we investigated the association between instrumental music training in childhood and outcomes closely related to as well those more distantly related.