A5088204461- Intracerebral and Subarachnoid Hemorrhage Research
- Neurobiology of Language and Bilingualism
- Acute Ischemic Stroke Management
- Neurosurgical Procedures and Complications
- Dysphagia Assessment and Management
- Neuroscience and Music Perception
- Advanced Neuroimaging Techniques and Applications
- Restless Legs Syndrome Research
- Nosocomial Infections in ICU
- Cerebrovascular and Carotid Artery Diseases
- Hip and Femur Fractures
- Transcranial Magnetic Stimulation Studies
- Bone fractures and treatments
- Multisensory perception and integration
- Tracheal and airway disorders
- Orthopaedic implants and arthroplasty
- Healthcare Decision-Making and Restraints
- Health and Medical Research Impacts
- Esophageal and GI Pathology
- Stroke Rehabilitation and Recovery
- Action Observation and Synchronization
- Sex and Gender in Healthcare
- Cerebrospinal fluid and hydrocephalus
- Academic Writing and Publishing
- Otolaryngology and Infectious Diseases
Beth Israel Deaconess Medical Center
2014-2025
Harvard University
2013-2025
Hadassah Medical Center
2022-2024
Arcadia
2024
Beth Israel Deaconess Hospital
2022-2023
Stroke Association
2015-2016
Istituto Ortopedico Gaetano Pini
2013
University of Milan
2013
University of Zurich
2007
Recovery from aphasia can be achieved through recruitment of either perilesional brain regions in the affected hemisphere or homologous language nonlesional hemisphere. For patients with large left-hemisphere lesions, recovery right may only possible path. The right-hemisphere most likely to play a role this process are superior temporal lobe (important for auditory feedback control), premotor regions/posterior inferior frontal gyrus planning and sequencing motor actions auditory-motor...
Previous studies have suggested that patients' potential for poststroke language recovery is related to lesion size; however, location may also be of importance, particularly when fiber tracts are critical the sensorimotor mapping sounds articulation (eg, arcuate fasciculus) been damaged. In this study, we tested hypothesis loads fasciculus (ie, volume affected by a patient's lesion) and 2 other involved in processing (the extreme capsule uncinate inversely severity speech production...
Importance Atrial cardiopathy is associated with stroke in the absence of clinically apparent atrial fibrillation. It unknown whether anticoagulation, which has proven benefit fibrillation, prevents patients and no Objective To compare anticoagulation vs antiplatelet therapy for secondary prevention cryptogenic evidence cardiopathy. Design, Setting, Participants Multicenter, double-blind, phase 3 randomized clinical trial 1015 participants cardiopathy, defined as P-wave terminal force...
IT HAS BEEN REPORTED THAT PATIENTS WITH SEVERELY nonfluent aphasia are better at singing lyrics than speaking the same words. This observation inspired development of Melodic Intonation Therapy (MIT), a treatment whose effects have been shown, but efficacy is unproven and neural correlates remain unidentified. Because its potential to engage/unmask language-capable regions in unaffected right hemisphere, MIT particularly well suited for patients with large left-hemisphere lesions. Using two...
It has been reported for more than 100 years that patients with severe nonfluent aphasia are better at singing lyrics they speaking the same words. This observation led to development of melodic intonation therapy (MIT). However, efficacy this yet be substantiated in a randomized controlled trial. Furthermore, its underlying neural mechanisms remain unclear. The two unique components MIT words and simple phrases using contour follows prosody speech rhythmic tapping left hand accompanies...
Pneumonia is a major complication of stroke, but effective prevention strategies are lacking. Since aspiration oropharyngeal secretions the primary mechanism for development stroke-associated pneumonia, that decrease oral colonization with pathogenic bacteria may help curtail pneumonia risk. We therefore hypothesized systematic care protocols can risk in hospitalized stroke patients. In this study, we investigated impact hygiene (OHC) program reducing hospital-acquired patients...
There is a need to identify biomarkers that predict degree of chronic speech fluency/language impairment and potential for improvement after stroke. We previously showed the Arcuate Fasciculus lesion load (AF-LL), combined variable site size, predicted fluency in patients with aphasia. In current study, we compared loads such structural map (i.e., AF-LL) those functional [i.e., gray matter (fGM-LL)] their ability naming performance large group patients. The fGM was constructed from brain...
Using an adapted version of Melodic Intonation Therapy (MIT), we treated adolescent girl with a very large left‐hemisphere lesion and severe nonfluent aphasia secondary to ischemic stroke. At the time her initial assessment 15 months after stroke, she had reached plateau in recovery despite intense long‐term traditional speech‐language therapy (approximately five times per week for more than one year). Following intensive course treatment our form MIT, performance improved on both trained...
Despite the fact that as many 25% of children diagnosed with autism spectrum disorders are nonverbal, surprisingly little research has been conducted on this population. In particular, mechanisms underlie their absence speech remain unknown. Using diffusion tensor imaging, we compared structure a language‐related white matter tract (the arcuate fasciculus, AF) in five completely nonverbal to typically developing children. We found that, group, did not show expected left–right AF...
Objective Pneumonia is a morbid complication of stroke, but evidence‐based strategies for its prevention are lacking. Acid‐suppressive medications have been associated with increased risk nosocomial pneumonia in hospitalized patients. It unclear whether these results can be extrapolated to stroke patients, where other factors strongly modulate risk. We investigated the association between acid‐suppressive medication and hospital‐acquired patients acute stroke. Methods All ischemic or...
<b><i>Introduction:</i></b> The benefits and risks of HMG-CoA reductase inhibitor (statin) drugs in survivors intracerebral hemorrhage (ICH) are unclear. Observational studies suggest an association between statin use increased risk lobar ICH, particularly patients with apolipoprotein-E (APOE) ε2 ε4 genotypes. There no randomized controlled trials addressing the effects statins after ICH leading to uncertainty as whether should be used who at high for recurrence....
Abstract Patients with large left‐hemisphere lesions and post‐stroke aphasia often remain nonfluent. Melodic intonation therapy (MIT) may be an effective alternative to traditional speech for facilitating recovery of fluency in those patients. In open‐label, proof‐of‐concept study, 14 subjects nonfluent (171 ± 76 cc) underwent two speech/language assessments before, one at the midpoint, after end 75 sessions (1.5 h/session) MIT. Functional MR imaging was done before asking vocalize same set...
Introduction: Cerebral small vessel disease (CSVD) is a major cause of primary lobar intracerebral hemorrhage (ICH) due to cerebral amyloid angiopathy (CAA) or hypertensive arteriopathy (HA). Sex differences in CSVD imaging markers and prevalence CAA vs HA ICH remain unexplored. Methods: We performed retrospective analysis patients with who underwent MRI during hospitalization. collected demographic, clinical, outcome data. reviewed MRIs for calculated composite burden score (cCSVDbs)....
Recent findings of a tight coupling between visual and auditory association cortices during multisensory perception in monkeys humans raise the question whether consistent paired presentation simple stimuli prompts conditioned responses unimodal regions or multimodal cortex once are presented isolation post-conditioning run. To address this issue fifteen healthy participants partook "silent" sparse temporal event-related fMRI study. In first (visual control) habituation phase they were with...
<b><i>Background:</i></b> Many patients with acute intracerebral hemorrhages (ICHs) undergo endotracheal intubation subsequent mechanical ventilation (MV) for “airway protection” the intent to prevent aspiration, pneumonias, and its related mortality. Conversely, these procedures may independently promote pneumonia, laryngeal trauma, dysphagia, adversely affect patient outcomes. The net benefit of MV in this cohort has not been systematically investigated....
Abstract Dysphagia is a serious stroke complication but lacks effective therapy . We investigated safety and preliminary efficacy of anodal transcranial direct current stimulation (atDCS) paired with swallowing exercises in improving post-stroke dysphagia from an acute unilateral hemispheric infarction (UHI). conducted double-blind, early phase-2 randomized controlled trial, subjects (n = 42) moderate-severe [Penetration Aspiration Scale (PAS) score ≥ 4], acute-subacute UHI. Subjects were to...