A5088034421- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Stroke Rehabilitation and Recovery
- Cardiovascular Health and Disease Prevention
- Intracranial Aneurysms: Treatment and Complications
- Intracerebral and Subarachnoid Hemorrhage Research
- Moyamoya disease diagnosis and treatment
- Venous Thromboembolism Diagnosis and Management
- Advanced Neuroimaging Techniques and Applications
- Vascular Malformations Diagnosis and Treatment
- Advanced MRI Techniques and Applications
- Spatial Neglect and Hemispheric Dysfunction
- HIV-related health complications and treatments
- Neurological Complications and Syndromes
- Neurological Disease Mechanisms and Treatments
- Pregnancy and preeclampsia studies
- Neurobiology of Language and Bilingualism
- Neurological Disorders and Treatments
- Functional Brain Connectivity Studies
- Transcranial Magnetic Stimulation Studies
- Optical Imaging and Spectroscopy Techniques
- Blood Pressure and Hypertension Studies
- Cerebrospinal fluid and hydrocephalus
- Neurosurgical Procedures and Complications
Columbia University Irving Medical Center
2016-2025
Columbia University
2016-2025
University of Otago
2024
Saint Louis University
2023
Cornell University
2011-2023
The Neurological Institute
1999-2023
The University of Texas Health Science Center at Houston
2023
Georgetown University Medical Center
2023
Georgetown University
2023
Cedars-Sinai Medical Center
2023
Whether brain imaging can identify patients who are most likely to benefit from therapies for acute ischemic stroke and whether endovascular thrombectomy improves clinical outcomes in such remains unclear.
Background and Purpose —Recovery from hemiparesis due to corticospinal tract infarction is well documented, but the mechanism of recovery unknown. Functional MRI (fMRI) provides a means identifying focal brain activity related movement paretic hand. Although prior studies have suggested that supplementary motor regions in ipsilesional contralesional hemisphere play role recovery, little known about time course cortical activation these as proceeds. Methods —Eight patients with first-ever...
Background. Motor recovery after stroke is predicted only moderately by clinical variables, implying that there still a substantial amount of unexplained, biologically meaningful variability in recovery. Regression diagnostics can indicate whether this associated simply with Gaussian error or instead multiple subpopulations vary their relationships to the variables. Objective. To perform regression on linear model for versus predictors. Methods. Forty-one patients ischemic were studied....
Background and Purpose— Most improvement from poststroke aphasia occurs within the first 3 months, but there remains unexplained variability in recovery. Recently, we reported a strong correlation between initial impairment change scores motor recovery at 90 days. We wanted to determine whether (defined as baseline days) shows comparably relation was similar that Methods— Twenty-one stroke patients had on Western Aphasia Battery (WAB) obtained admission (WAB ) days mo ). The actual (Δ) WAB −...
Importance Atrial cardiopathy is associated with stroke in the absence of clinically apparent atrial fibrillation. It unknown whether anticoagulation, which has proven benefit fibrillation, prevents patients and no Objective To compare anticoagulation vs antiplatelet therapy for secondary prevention cryptogenic evidence cardiopathy. Design, Setting, Participants Multicenter, double-blind, phase 3 randomized clinical trial 1015 participants cardiopathy, defined as P-wave terminal force...
Hemineglect was assessed in 34 patients with right-hemisphere stroke using a letter-cancellation task and line bisection task. No significant correlation (r = .39) found between scores on the two tests. Ten who showed neglect cancellation but performed normally had frontal or deep lesions. Eleven posterior lesions deviated rightward bisection; several of these minimal no deficit. A nonmotor involving judgment bisected also abnormally by six shift, suggesting that such shift does not result...
Background and Purpose Focal neurological deficits (FNDs) in patients with arteriovenous malformations (AVMs) have been widely attributed to the phenomenon of “cerebral steal.” The incidence focal was investigated a large prospective sample. Methods Using data from patient history examination, CT or MRI, transcranial Doppler sonography, we studied 152 consecutive, AVM for evidence FNDs unrelated hemorrhagic event. Feeding mean arterial pressure measured during superselective angiography....
<h3>Background:</h3> Predicting aphasia recovery after stroke has been difficult due to substantial variability in outcomes. Few studies have characterised the nature and extent of recovery, beginning with baselines at 24–72 hours onset. <h3>Aim:</h3> To characterise course language first-time stroke. <h3>Methods:</h3> Using our Performance Recovery Stroke Study (PARIS) database, we evaluated consecutive patients diffusion-weighted-image-positive lesions on admission 90 days....
Background. Constraint-induced movement therapy (CIMT) has proven effective in increasing functional use of the affected arm patients with chronic stroke. The mechanism CIMT is not well understood. Objective. To demonstrate, a proof-of-concept study, feasibility using kinematic measures conjunction clinical outcome to better understand recovery stroke mild moderate motor impairments who undergo CIMT. Methods. A total 10 were enrolled modified protocol over 2 weeks. Treatment response was...
There is substantial interpatient variation in recovery from upper limb impairment after stroke patients with severe initial impairment. Defining as a change the Fugl-Meyer score (ΔFM), we predicted ΔFM its conditional expectation (i.e., posterior mean) given (FM(ii)) and putative functional magnetic resonance imaging (fMRI) measure. Patients first time, ischemic were imaged at 2.5 ± 2.2 days poststroke 1.5-T fMRI during hand closure task alternating rest (fundamental frequency = 0.025 Hz,...
Preeclampsia affects 3% to 8% of pregnancies and increases risk pregnancy-associated stroke (PAS). Data are limited on which women with preeclampsia at highest for PAS.Using billing data from the 2003 2012 New York State Department Health inpatient database, we matched PAS 1:3 preeclamptic controls based age race/ethnicity. Pre-defined factors included pregnancy complications, infection present admission, vascular factors, prothrombotic states, coagulopathies. We constructed multivariable...
The Stroke Imaging Research (STIR) group, the Working Group of StrokeNet, American Society Neuroradiology, and Foundation Neuroradiology sponsored an imaging session workshop during Treatment Academy Industry Roundtable (STAIR) IX on October 5 to 6, 2015 in Washington, DC. purpose this roadmap was focus role future research clinical trials.This forum brought together stroke neurologists, neuroradiologists, neuroimaging scientists, members National Institute Neurological Disorders (NINDS),...
Background Magnetic resonance imaging of carotid plaque can aid in stroke risk stratification patients with stenosis. However, the prevalence complicated cryptogenic is uncertain, especially as assessed by techniques routinely included acute magnetic protocols. We whether angiography–defined presence intraplaque high‐intensity signal ( IHIS ), a marker hemorrhage, associated ipsilateral stroke. Methods and Results Cryptogenic evidence unilateral anterior circulation infarction without...
Dynamic cerebral autoregulation (DCA) is the continuous counterregulation of blood flow to fluctuations in pressure. DCA can become impaired after acute stroke, but it remains unclear what extent and over interval this occurs.We included 28 patients (NIHSS = 12 ± 6.5, age 68.4 17.1, 16F) with large-vessel ischemic stroke middle artery territory 29 healthy controls (mean 54.9 9, 16F). was assessed by simultaneous measurement pressure together velocities using finger plethysmography/arterial...
Patients with stroke-like symptoms may be underutilising emergency medical services and avoiding hospitalisation during the COVID-19 pandemic. We investigated a decline in admissions for stroke transient ischaemic attack (TIA) department (ED) alert activations. retrospectively compiled total weekly hospital TIA between 31 December 2018 21 April 2019 versus 30 19 2020 at five US tertiary academic comprehensive centres cities early outbreaks Boston, New York City, Providence Seattle. collected...
To determine whether functional magnetic resonance imaging activation obtained in the first few days after stroke correlates with subsequent motor recovery.Twenty-three patients hemiparesis first-time were scanned at 2.0 +/- 0.9 while performing a simple task. We defined recovery as change Fugl-Meyer score from time of scan to approximately 3 months later (90 8 days). performed three different tests assess correlations between brain and score: (1) multivariate (most sensitive spatially...
The object of this study was to report the clinical features, surgical treatment, and long-term outcomes in adults with moyamoya phenomenon treated at a single institution US.Forty-three adult patients disease (mean age 40 +/- 11 years [SD], range 18-69 years) were encephaloduroarteriosynangiosis (EDAS). Neurologists examined pre- postoperatively. Follow-up obtained person or by structured telephone interview (median 41 months, 4-126 months). following collected: transient ischemic attack...
<h3>Background:</h3> Motor dysfunction in the contralateral hand has been well characterised after stroke. The ipsilateral received less attention, yet may provide valuable insights into structure of motor system and nature recovery process. By tracking function both hands beginning acute stroke period patients with cortical versus subcortical lesions, we sought to understand functional anatomy deficit. <h3>Methods:</h3> We examined 30 first-ever unilateral hemiparetic stroke, 23 lesions...
To determine whether unihemispheral hemodynamic failure is independently associated with cognitive impairment among participants in the National Institute of Neurological Disorders and Stroke-sponsored, multicenter, randomized clinical trial, Randomized Evaluation Carotid Occlusion Neurocognition (RECON).
IMPORTANCETreatments for symptomatic intracerebral hemorrhage (sICH) are based on expert opinion, with limited data available efficacy.OBJECTIVE To better understand the natural history of thrombolysis-related sICH, a focus efficacy various treatments used.