A5044047568- Genetic Associations and Epidemiology
- Substance Abuse Treatment and Outcomes
- Alcohol Consumption and Health Effects
- Neurotransmitter Receptor Influence on Behavior
- Epigenetics and DNA Methylation
- Child and Adolescent Psychosocial and Emotional Development
- Genetics and Neurodevelopmental Disorders
- Cannabis and Cannabinoid Research
- Stress Responses and Cortisol
- Birth, Development, and Health
- Tryptophan and brain disorders
- Receptor Mechanisms and Signaling
- Bipolar Disorder and Treatment
- Nicotinic Acetylcholine Receptors Study
- Smoking Behavior and Cessation
- Genetic Mapping and Diversity in Plants and Animals
- Schizophrenia research and treatment
- Autism Spectrum Disorder Research
- Health, Environment, Cognitive Aging
- Resilience and Mental Health
- Cognitive Abilities and Testing
- Attention Deficit Hyperactivity Disorder
- Posttraumatic Stress Disorder Research
- Child Abuse and Trauma
- Neuropeptides and Animal Physiology
Yale University
2016-2025
VA Connecticut Healthcare System
2016-2025
Yale Cancer Center
2025
Connecticut Health Foundation
2015-2024
University of Pennsylvania
2003-2024
California Department of Education
2023-2024
United States Department of Veterans Affairs
2006-2024
VA Connecticut Research and Education Foundation
1992-2024
California University of Pennsylvania
2023-2024
Johns Hopkins Medicine
1995-2024
Although changes in nucleotide sequence affecting the composition and structure of proteins are well known, functional resulting from substitutions cannot always be inferred simple analysis DNA sequence. Because a strong synonymous codon usage bias human DRD2 gene, suggesting selection on positions, was revealed by relative independence G+C content third positions isochoric frequencies, we chose to investigate effects six known naturally occurring (C132T, G423A, T765C, C939T, C957T, G1101A)...
In this study, measures of the quality and availability social supports were found to moderate risk for depression associated with a history maltreatment presence short (s) allele serotonin transporter gene promoter polymorphism (5-HTTLPR). The present investigation (i) replicates research in adults showing that 5-HTTLPR variation moderates development after stress, (ii) extends finding children, (iii) demonstrates ability further depression. Maltreated children s/s genotype no positive had...
Abstract Alcohol consumption level and alcohol use disorder (AUD) diagnosis are moderately heritable traits. We conduct genome-wide association studies of these traits using longitudinal Use Disorder Identification Test-Consumption (AUDIT-C) scores AUD diagnoses in a multi-ancestry Million Veteran Program sample ( N = 274,424). identify 18 significant loci: 5 associated with both traits, 8 AUDIT-C only, only. Polygenic Risk Scores (PRS) for alcohol-related disorders two independent samples....
Disasters are associated with increased risk of posttraumatic stress disorder (PTSD) and major depression, but no study, to the authors' knowledge, has determined whether genotype interacts disaster exposure social support moderate these phenotypes. The authors tested hypothesis that a polymorphism in serotonin transporter gene (locus, SLC6A4; variant, 5-HTTLPR) moderates posthurricane PTSD depression given high hurricane low support.The interviewed household probability sample adults 6-9...
DYX2 on 6p22 is the most replicated reading disability (RD) locus. By saturating a previously identified peak of association with single nucleotide polymorphism markers, we large polymorphic deletion that encodes tandem repeats putative brain-related transcription factor binding sites in intron 2 DCDC2 . Alleles this compound repeat are significant disequilibrium multiple traits. RT-PCR data show localizes to regions brain where fluent occurs, and RNA interference studies down-regulation...
Although the prevalence of depression among medical interns substantially exceeds that general population, specific factors responsible are not well understood. Recent reports a moderating effect genetic polymorphism (5-HTTLPR) in serotonin transporter protein gene on likelihood life stress will precipitate may help to understand development mood symptoms interns.To identify psychological, demographic, and residency program associated with use internship as model study effects this...
Anxiety disorders are common and often disabling. The goal of this study was to examine the genetic architecture anxiety symptoms, which also frequently comorbid with other mental disorders, such as major depressive disorder.