A5000611728- Substance Abuse Treatment and Outcomes
- Genetic Associations and Epidemiology
- Alcohol Consumption and Health Effects
- Child and Adolescent Psychosocial and Emotional Development
- Cognitive Abilities and Testing
- Attachment and Relationship Dynamics
- Prenatal Substance Exposure Effects
- Homelessness and Social Issues
- Family Dynamics and Relationships
- Behavioral Health and Interventions
- Epigenetics and DNA Methylation
- Suicide and Self-Harm Studies
- Genetic Mapping and Diversity in Plants and Animals
- Cannabis and Cannabinoid Research
- Health disparities and outcomes
- Birth, Development, and Health
- Health, Environment, Cognitive Aging
- Mental Health Research Topics
- Early Childhood Education and Development
- Peroxisome Proliferator-Activated Receptors
- Neurotransmitter Receptor Influence on Behavior
- Child Abuse and Trauma
- Intergenerational Family Dynamics and Caregiving
- Obesity, Physical Activity, Diet
- COVID-19 and Mental Health
Johnson University
2022-2025
Rutgers, The State University of New Jersey
2021-2025
Rutgers Sexual and Reproductive Health and Rights
2022-2025
Virginia Commonwealth University
2014-2024
Lund University
2016-2024
Rutgers Health
2023
Mount Holyoke College
2022
Macalester College
2016
Swarthmore College
2016
University of Minnesota
2011-2012
Antisocial behavior (ASB) places a large burden on perpetrators, survivors, and society. Twin studies indicate that half of the variation in this trait is genetic. Specific causal genetic variants have, however, not been identified.
Introduction: Research has identified multiple risk factors associated with suicide attempt (SA) among individuals psychiatric illness. However, there is limited research those an alcohol use disorder (AUD), despite their disproportionately higher rates of SA. Methods: We examined lifetime SA in 4,068 AUD from the Collaborative Study on Genetics Alcoholism (23% SA; 53% female; mean age: 38). explored for across other clinical conditions ascertained a interview, polygenic scores comorbid...
Finding genes involved in complex behavioral outcomes, and understanding the pathways by which they confer risk, is a challenging task, necessitating large samples that are phenotypically well characterized across time. We describe an effort to create university-wide research project aimed at how environments impact alcohol use related substance mental health outcomes time college students. Nearly 70% of incoming freshman class (N=2715) completed on-line surveys, with 80% students from fall...
In this project, we aimed to bring large-scale gene-identification findings into a developmental psychopathology framework. Using family-based sample, tested whether polygenic scores for externalizing disorders—based on single nucleotide polymorphism weights derived from genome-wide association study results in adults ( n = 1,249)—predicted disorders, subclinical behavior, and impulsivity-related traits among adolescents 248) young 207) parenting peer factors adolescence moderated risk...
This paper provides an overview of the most recent assessment, collected in early midlife, FinnTwin12 cohort, a population-based study Finnish twins born 1983-1987. The were invited to complete online survey assessing range variables, including physical and mental health, alcohol use problems, other substance use, midlife environments (e.g., parenthood). In total, 2,085 individuals (~ 40% original sample) completed (551 twin pairs, 58.7% female, 37.3% monozygotic, Mage = 37.2 years, SD 1.47...
This study adopted a developmental perspective on recovery from conflict in romantic relationships. Participants were 73 young adults (target participants), studied since birth, and their partners. A novel observational coding scheme was used to evaluate each participant's degree of recovery, operationalized as the extent which participant disengaged during 4-min "cool-down" task immediately following 10-min discussion. Conflict systematically associated with dyadic processes. Targets who...
Alcohol problems represent a classic example of complex behavioral outcome that is likely influenced by many genes small effect. A polygenic approach, which examines aggregate measured genetic effects, can have predictive power in cases where individual or variants do not. In the current study, we first tested whether risk for alcohol problems-derived from genome-wide association estimates an factor score age 18 assessment Avon Longitudinal Study Parents and Children (ALSPAC; n = 4304...
We tested hypotheses concerning the developmental roots of becoming “weak-link” (less committed) partner in adult romantic relationships and associations between partners’ absolute relative levels commitment dyadic outcomes. examined 78 target 20- to 21-year-olds who were involved a relationship had been studied since birth. As predicted, people received lower-quality support from caregivers toddlerhood or less able resolve conflicts with best friend midadolescence more likely become...
Background All stages of development alcohol use disorder ( AUD ) have not been equally studied. While initiation drinking has given considerable attention, other as thoroughly investigated. It is clear whether the same factors are associated consistently across early and late transitions in involvement. High‐risk family samples that enriched for vulnerability offer an opportunity to examine influences multiple development. Methods Data from adolescents young adults high‐risk families were...
The authors sought to clarify the relationship between marriage and risk for alcohol use disorder.The association marital status first registration disorder in medical, criminal, pharmacy registries was assessed a population-based Swedish cohort (N=3,220,628) using longitudinal time-dependent survival co-relative designs.First associated with substantial decline onset of men (hazard ratio=0.41, 95% CI=0.40-0.42) women ratio=0.27, CI=0.26-0.28). This slightly stronger when spouse had no...
Objective: The purpose of this study was to clarify the magnitude and nature relationship between divorce risk for alcohol use disorder (AUD). Method: In a population-based Swedish sample married individuals (N=942,366), authors examined association or widowhood first registration AUD. AUD assessed using medical, criminal, pharmacy registries. Results: Divorce strongly associated with onset in both men (hazard ratio=5.98, 95% CI=5.65–6.33) women ratio=7.29, CI=6.72–7.91). hazard ratio...
Identification of causal variants and genes underlying genome-wide association study (GWAS) loci is essential to understand the biology alcohol use disorder (AUD) drinks per week (DPW). Multi-omics integration approaches have shown potential for fine mapping complex obtain biological insights disease mechanisms. In this study, we multi-omics approaches, fine-map AUD DPW associations at single SNP resolution demonstrate that rs56030824 on chromosome 11 significantly reduces SPI1 mRNA...
Adopting an organizational view on social development, we have investigated how interpersonal experiences early in life prospectively predict well individuals resolve relationship conflicts, recover from and stable, satisfying relationships with their romantic partners adulthood. We also identified specific intervening during middle childhood adolescence that mediate the connection between regulated emotions parents very as young adults relationships. discuss many advantages of adopting development.
Objective: The study of sex differences has been identified as one way to enhance scientific reproducibility, and the National Institutes Health (NIH) have implemented a new policy encourage explicit examination differences. Our goal here is address in behavioral genetic research on alcohol outcomes. Method: We review for outcomes whether source magnitude influences consumption use disorder (AUD) are same across sexes; describe common designs studying sex-specific gene-by-environment...
The endophenotype concept was first proposed as a strategy to use (purportedly) genetically simpler phenotypes in gene identification studies for psychiatric disorders, and is distinct from the closely related of intermediate phenotypes. In area alcohol disorder (AUD) research, two candidate endophenotypes have produced replicable genetic associations: level response neurophysiology markers (e.g., event-related oscillations potentials). Additional cognitive, sensory, neuroimaging literatures...
Abstract Predictive models for recovering from alcohol use disorder (AUD) and identifying related predisposition biomarkers can have a tremendous impact on addiction treatment outcomes cost reduction. Our sample ( N = 1376) included individuals of European (EA) African (AA) ancestry the Collaborative Study Genetics Alcoholism (COGA) who were initially assessed as having AUD (DSM-5) reassessed years later either or in remission. To predict this difference recovery status, we analyzed initial...
The COVID-19 pandemic has dramatically altered everyday life worldwide, and some individuals may be at increased risk for pandemic-related distress. In a U.S. community sample ( N = 236, 64% female; 78% White; mean age 30.3 years) assessed before during the initial surge, we examined, prospectively, whether disruptions history of adverse childhood experiences (ACEs) were associated with changes in depressive symptoms, stress, sleep, relationship satisfaction, substance use over time...
There is growing interest in how peers' genotypes may influence health (i.e., peer social genetic effects). The authors sought to clarify the nature of effects on risk for drug use disorder, alcohol disorder (AUD), major depression, and anxiety disorder.