Anke R. Hammerschlag
A5042968896- Genetic Associations and Epidemiology
- Child and Adolescent Psychosocial and Emotional Development
- Genetics and Neurodevelopmental Disorders
- Nutrition, Genetics, and Disease
- Epigenetics and DNA Methylation
- Health, Environment, Cognitive Aging
- Cognitive Abilities and Testing
- Adolescent and Pediatric Healthcare
- Genetic Mapping and Diversity in Plants and Animals
- Bioinformatics and Genomic Networks
- Functional Brain Connectivity Studies
- Amyotrophic Lateral Sclerosis Research
- Attention Deficit Hyperactivity Disorder
- Advanced Neuroimaging Techniques and Applications
- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Smoking Behavior and Cessation
- Folate and B Vitamins Research
- Genomics and Rare Diseases
- Sleep and related disorders
- Maternal Mental Health During Pregnancy and Postpartum
- Alcohol Consumption and Health Effects
- Birth, Development, and Health
- Obesity, Physical Activity, Diet
- Bipolar Disorder and Treatment
Vrije Universiteit Amsterdam
2017-2023
The University of Queensland
2019-2022
Amsterdam University Medical Centers
2020-2021
Amsterdam Neuroscience
2014-2019
University of Amsterdam
2018
Erasmus MC
2015-2017
Cognitive Research (United States)
2017
Amsterdam UMC Location Vrije Universiteit Amsterdam
2013-2015
Czech Academy of Sciences, Institute of Psychology
2013-2014
Leiden University Medical Center
2013-2014
Antisocial behavior (ASB) places a large burden on perpetrators, survivors, and society. Twin studies indicate that half of the variation in this trait is genetic. Specific causal genetic variants have, however, not been identified.
We aimed to investigate whether cognitive deficits and structural functional connectivity changes can be detected before symptom onset in a large cohort of carriers microtubule-associated protein tau progranulin mutations.In this case-control study, 75 healthy individuals (aged 20-70 years) with 50% risk for frontotemporal dementia (FTD) underwent DNA screening, neuropsychological assessment, MRI. used voxel-based morphometry tract-based spatial statistics voxelwise analyses gray matter...
<h3>Objective:</h3> We aimed to investigate whether cognitive deficits and structural functional connectivity changes can be detected before symptom onset in a large cohort of carriers <i>MAPT</i> (microtubule-associated protein tau) or <i>GRN</i> (progranulin) mutations. <h3>Methods:</h3> In this case-control study, 75 healthy individuals (aged 20–70 years) with 50% risk frontotemporal dementia (FTD) underwent DNA screening, neuropsychological assessment, MRI, fMRI. used voxel-based...
Abstract Humans vary substantially in their willingness to take risks. In a combined sample of over one million individuals, we conducted genome-wide association studies (GWAS) general risk tolerance, adventurousness, and risky behaviors the driving, drinking, smoking, sexual domains. We identified 611 approximately independent genetic loci associated with at least our phenotypes, including 124 tolerance. report evidence substantial shared influences across tolerance behaviors: 72 contain...
The MIR137 locus is a replicated genetic risk factor for schizophrenia. risk-associated allele reported to increase miR-137 expression and overexpression alters synaptic transmission in mouse hippocampus. We investigated the cellular mechanisms underlying these observed effects hippocampal neurons culture. First, we correlated of genes human postmortem brain. Some evidence increased MIR137HG was observed, especially hippocampus disease-associated genotype. Second, neurons, confirmed...
Neuroticism is an important risk factor for psychiatric traits including depression 1 , anxiety 2,3 and schizophrenia 4–6 . Previous genome-wide association studies 7–12 (GWAS) reported 16 genomic loci 10–12 Here we report the largest neuroticism GWAS meta-analysis to date (N=449,484), identify 136 independent significant (124 novel), implicating 599 genes. Extensive functional follow-up analyses show enrichment in several brain regions involvement of specific cell-types, dopaminergic...
Mounting evidence shows genetic overlap between multiple psychiatric disorders. However, the biological underpinnings of shared risk for disorders are not yet fully uncovered. The identification underlying mechanisms is crucial progress in treatment these disorders.We applied gene-set analysis including 7372 gene sets, and 53 tissue-type specific gene-expression profiles to identify sets genes that involved etiology We included genome-wide meta-association data five schizophrenia, bipolar...
Substantial genetic correlations have been reported across psychiatric disorders and numerous cross-disorder variants detected. To identify the underlying general psychopathology in childhood, we performed a genome-wide association study using total problem score. We analyzed 6,844,199 common SNPs 38,418 school-aged children from 20 population-based cohorts participating EAGLE consortium. The SNP heritability of problems was 5.4% (SE = 0.01) two loci reached significance: rs10767094...
Abstract Insomnia is the second-most prevalent mental disorder, with no sufficient treatment available. Despite a substantial role of genetic factors, only handful genes have been implicated and insight into associated neurobiological pathways remains limited. Here, we use an unprecedented large association sample (N=1,331,010) to allow detection number variants gain biological functions, cell types tissues involved in insomnia complaints. We identify 202 genome-wide significant loci...