Ronald de Vlaming
A5083193617- Genetic Associations and Epidemiology
- Genetic Mapping and Diversity in Plants and Animals
- Cognitive Abilities and Testing
- Genetic and phenotypic traits in livestock
- Nutrition, Genetics, and Disease
- Intergenerational and Educational Inequality Studies
- Birth, Development, and Health
- Genetics and Neurodevelopmental Disorders
- Epigenetics and DNA Methylation
- Bioinformatics and Genomic Networks
- Functional Brain Connectivity Studies
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Folate and B Vitamins Research
- Economic Growth and Productivity
- Health, Environment, Cognitive Aging
- Sex and Gender in Healthcare
- Child and Adolescent Psychosocial and Emotional Development
- Bipolar Disorder and Treatment
- Liver Disease Diagnosis and Treatment
- Cardiovascular Disease and Adiposity
- Adolescent and Pediatric Healthcare
- Orthodontics and Dentofacial Orthopedics
- Biomedical Text Mining and Ontologies
- Protein Tyrosine Phosphatases
- Image and Signal Denoising Methods
Vrije Universiteit Amsterdam
2017-2025
Tinbergen Institute
2023
Erasmus University Rotterdam
2015-2022
Amsterdam Neuroscience
2018
Erasmus MC
2015-2016
Abstract We conduct a genome-wide association study (GWAS) of educational attainment (EA) in sample ~3 million individuals and identify 3,952 approximately uncorrelated genome-wide-significant single-nucleotide polymorphisms (SNPs). A polygenic predictor, or index (PGI), explains 12–16% EA variance contributes to risk prediction for ten diseases. Direct effects (i.e., controlling parental PGIs) explain roughly half the PGI’s magnitude with other phenotypes. The correlation between mate-pair...
Understanding which biological pathways are specific versus general across diagnostic categories and levels of symptom severity is critical to improving nosology treatment psychopathology. Here, we combine transdiagnostic dimensional approaches genetic discovery for the first time, conducting a novel multivariate genome-wide association study eight psychiatric symptoms disorders broadly related mood disturbance psychosis. We identify two liabilities that distinguish between common forms...
Abstract We conducted a genome-wide association study on income among individuals of European descent ( N = 668,288) to investigate the relationship between socio-economic status and health disparities. identified 162 genomic loci associated with common genetic factor underlying various measures, all small effect sizes (the Income Factor). Our polygenic index captures 1–5% variance, only one fourth due direct effects. A phenome-wide using this showed reduced risks for diseases including...
Educational attainment is associated with many health outcomes, including longevity. It also known to be substantially heritable. Here, we used data from three large genetic epidemiology cohort studies (Generation Scotland, n = ∼17,000; UK Biobank, ∼115,000; and the Estonian ∼6,000) test whether education-linked variants can predict lifespan length. We did so by using members' polygenic profile score for education their parents' Across cohorts, meta-analysis showed that a 1 SD higher was...
Abstract We conducted genome-wide association studies (GWAS) of relative intake from the macronutrients fat, protein, carbohydrates, and sugar in over 235,000 individuals European ancestries. identified 21 unique, approximately independent lead SNPs. Fourteen SNPs are uniquely associated with one macronutrient at significance ( P < 5 × 10 −8 ), while five reach suggestive 1 −5 ) for least other macronutrient. While phenotypes genetically correlated, each phenotype carries a partially...
Higher educational attainment (EA) is negatively associated with schizophrenia (SZ). However, recent studies found a positive genetic correlation between EA and SZ. We investigate possible causes of this counterintuitive finding using genome-wide association study results for SZ (N = 443,581) replication cohort (1169 controls; 1067 cases) deeply phenotyped patients. find strong dependence that cannot be explained by chance, linkage disequilibrium, or assortative mating. Instead, several...
Abstract Humans vary substantially in their willingness to take risks. In a combined sample of over one million individuals, we conducted genome-wide association studies (GWAS) general risk tolerance, adventurousness, and risky behaviors the driving, drinking, smoking, sexual domains. We identified 611 approximately independent genetic loci associated with at least our phenotypes, including 124 tolerance. report evidence substantial shared influences across tolerance behaviors: 72 contain...
Large-scale genome-wide association results are typically obtained from a fixed-effects meta-analysis of GWAS summary statistics multiple studies spanning different regions and/or time periods. This approach averages the estimated effects genetic variants across studies. In case heterogeneous studies, statistical power and predictive accuracy polygenic scores attenuated, contributing to so-called 'missing heritability'. Here, we describe online Meta-GWAS Accuracy Power (MetaGAP) calculator...
Abstract Methods for using GWAS to estimate genetic correlations between pairwise combinations of traits have produced “atlases” architecture. Genetic atlases reveal pervasive pleiotropy, and genome-wide significant loci are often shared across different phenotypes. We introduce genomic structural equation modeling (Genomic SEM), a multivariate method analyzing the joint architectures complex traits. Using formal methods covariance structure, Genomic SEM synthesizes SNP-heritabilities...
We develop a polygenic index for individual income and examine random differences in this with lifetime outcomes sample of ~35,000 biological siblings. find that genetic fortune higher causes greater socio-economic status better health, partly via intervenable environmental pathways such as education. The positive returns to schooling remain substantial even after controlling now observable confounds. Our findings illustrate inequalities education, income, health are due the lottery....
Abstract Understanding which biological pathways are specific versus general across diagnostic categories and levels of symptom severity is critical to improving nosology treatment psychopathology. Here, we combine transdiagnostic dimensional approaches genetic discovery for the first time, conducting a novel multivariate genome-wide association study (GWAS) eight psychiatric symptoms disorders broadly related mood disturbance psychosis. We identify two liabilities that distinguish between...
Failures of self-control can manifest as externalizing behaviors (e.g., aggression, rule-breaking) that have far-reaching negative consequences. Researchers long been interested in measuring children's genetic risk for to inform efforts at early identification and intervention. Drawing on data from the Environmental Risk Longitudinal Twin Study (N = 862 twins) Millennium Cohort 2,824 parent-child trios), two longitudinal cohorts UK, we leveraged molecular within-family designs test...
Abstract We conducted a genome-wide association study (GWAS) on income among individuals of European descent and leveraged the results to investigate socio-economic health gradient ( N =668,288). found 162 genomic loci associated with common genetic factor underlying various measures, all small effect sizes. Our GWAS-derived polygenic index captures 1 - 4% variance, only one-fourth attributed direct effects. A phenome-wide using this showed reduced risks for broad spectrum diseases,...