Kim V.E. Braun
A5015971933- Epigenetics and DNA Methylation
- Diet, Metabolism, and Disease
- RNA modifications and cancer
- Genetic Associations and Epidemiology
- Birth, Development, and Health
- Coffee research and impacts
- Diet and metabolism studies
- Nutritional Studies and Diet
- Cholesterol and Lipid Metabolism
- Nutrition, Genetics, and Disease
- Cancer-related gene regulation
- Biochemical Analysis and Sensing Techniques
- Genetic Syndromes and Imprinting
- Cancer-related molecular mechanisms research
- Pancreatic function and diabetes
- Consumer Attitudes and Food Labeling
- Childhood Cancer Survivors' Quality of Life
- Obesity, Physical Activity, Diet
Erasmus MC
2016-2023
Johns Hopkins University
2020
Harvard University
2018
DNA methylation is a key epigenetic mechanism that suggested to be associated with blood lipid levels. We aimed identify CpG sites at which levels are of triglycerides, high-density lipoprotein cholesterol (HDL-C), low-density (LDL-C), and total in 725 participants the Rotterdam Study, population-based cohort study. Subsequently, we sought replication non-overlapping set 760 participants. Genome-wide were measured whole using Illumina Methylation 450 array. Associations between beta values...
Abstract We conducted genome-wide association studies (GWAS) of relative intake from the macronutrients fat, protein, carbohydrates, and sugar in over 235,000 individuals European ancestries. identified 21 unique, approximately independent lead SNPs. Fourteen SNPs are uniquely associated with one macronutrient at significance ( P < 5 × 10 −8 ), while five reach suggestive 1 −5 ) for least other macronutrient. While phenotypes genetically correlated, each phenotype carries a partially...
We conducted an epigenome-wide association study on obesity-related traits. used data from 2 prospective, population-based cohort studies: the Rotterdam Study (RS) (2006–2013) and Atherosclerosis Risk in Communities (ARIC) (1990–1992). RS (n = 1,450) as discovery panel ARIC 2,097) replication panel. Linear mixed-effect models were to assess cross-sectional associations between genome-wide DNA methylation leukocytes body mass index (BMI) waist circumference (WC), adjusting for sex, age,...
DNA methylation patterns associated with habitual diet have not been well studied. Diet quality was characterized using a Mediterranean-style score and the Alternative Healthy Eating Index score. We conducted ethnicity-specific trans-ethnic epigenome-wide association analyses for leukocyte-derived at over 400 000 CpGs (cytosine-guanine dinucleotides) in 5 population-based cohorts including 6662 European ancestry, 2702 African 360 Hispanic ancestry participants. For diet-associated identified...
Dietary fiber (DF) intake may be beneficial for cardiometabolic health. However, whether this already occurs in early childhood is unclear. We investigated associations between DF infancy and health among 2032 children participating a population-based cohort The Netherlands. Information on at median age of 12.9 months was collected using food-frequency questionnaire. adjusted energy the residual method. At 6 years, body fat percentage, high-density lipoprotein (HDL)-cholesterol, insulin,...
Abstract Coffee and tea are extensively consumed beverages worldwide. Observational studies have shown contradictory findings for the association between consumption of these different health outcomes. Epigenetics is suggested as a mechanism mediating effects dietary lifestyle factors on disease onset. We conducted epigenome-wide (EWAS) coffee consumptions in 15,789 participants European African-American ancestries from 15 cohorts. EWAS meta-analysis revealed 11 CpG sites significantly...
Abstract Leukocyte DNA methylation patterns associated with habitual diet may reveal molecular mechanisms involved in the pathogenesis of diet-related chronic diseases and highlight targets for prevention treatment. We aimed to examine peripheral blood derived leukocyte signatures quality. meta-analyzed epigenome-wide associations between quality levels at over 400,000 cytosine-guanine dinucleotides (CpGs). conducted analysis primarily 6,662 European ancestry (EA) participants secondarily a...