A5073324048- Nutritional Studies and Diet
- Nutrition, Genetics, and Disease
- Cancer Risks and Factors
- Diet and metabolism studies
- Diet, Metabolism, and Disease
- Metabolomics and Mass Spectrometry Studies
- Liver Disease Diagnosis and Treatment
- Nutrition and Health in Aging
- Cardiovascular Health and Risk Factors
- Salivary Gland Disorders and Functions
- Consumer Attitudes and Food Labeling
- Oral microbiology and periodontitis research
- Cholesterol and Lipid Metabolism
- Folate and B Vitamins Research
- Antioxidant Activity and Oxidative Stress
- Lipid metabolism and disorders
- Bioinformatics and Genomic Networks
- Phytoestrogen effects and research
- Agriculture Sustainability and Environmental Impact
- Gut microbiota and health
- Genetic Associations and Epidemiology
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Advanced Proteomics Techniques and Applications
- Kruppel-like factors research
Brigham and Women's Hospital
2020-2025
Harvard University
2020-2025
SUNY Canton
2025
Harvard University Press
2024
Tufts University
2016-2023
Jean Mayer Human Nutrition Research Center on Aging
2017-2022
Lemuel Shattuck Hospital
2020
Limited data exist on the performance of high-throughput proteomics profiling in epidemiological settings, including impact specimen collection and within-person variability over time. Thus, Olink (972 proteins) SOMAscan7Kv4.1 (7322 proteoforms 6596 assays were utilized to measure protein concentrations archived plasma samples from Nurses' Health Studies Professionals Follow-Up Study. Spearman's correlation coefficients (r) intraclass (ICCs) used assess agreement between (1) 42 triplicate...
Abstract Experimental studies reported biochemical actions underpinning aging processes and mortality, but the relevant metabolic alterations in humans are not well understood. Here we examine associations of 243 plasma metabolites with mortality longevity (attaining age 85 years) 11,634 US (median follow-up 22.6 years, 4288 deaths) 1878 Spanish participants 14.5 525 deaths). We find that, higher levels N2,N2-dimethylguanosine, pseudouridine, N4-acetylcytidine, 4-acetamidobutanoic acid,...
A healthy lifestyle is associated with a lower premature mortality risk and longer life expectancy. However, the metabolic pathways of how they relate to longevity are unclear. We aimed identify replicate metabolomic signature examine it related total cause-specific longevity.
Soy foods possess both antiestrogenic and estrogen-like properties. It remains controversial whether women diagnosed with breast cancer should be advised to eat more or less soy foods, especially for those who receive hormone therapies as part of treatment.The association dietary intake isoflavone, the major phytoestrogen in soy, all-cause mortality was examined 6235 enrolled Breast Cancer Family Registry. Dietary assessed using a Food Frequency Questionnaire developed Hawaii-Los Angeles...
Background Limited data are available on the prospective relationship between beverage consumption and plasma lipid lipoprotein concentrations. Two major sources of sugar in US diet sugar-sweetened beverages (SSBs) 100% fruit juices. Low-calorie sweetened common replacements. Methods Results Fasting concentrations were measured FOS (Framingham Offspring Study) (1991-2014; N=3146) Generation Three (2002-2001; N=3584) cohorts. Beverage intakes estimated from food frequency questionnaires...
Metabolomics profiles were consistently associated with type 2 diabetes (T2D) risk, but evidence on long-term metabolite changes and T2D incidence is lacking. We examined the associations of 10-year plasma subsequent risk.We conducted a nested case-control study (n=244 cases, n=244 matched controls) within Nurses' Health Study. Repeated metabolomics profiling (170 targeted metabolites) was in participant blood specimens from 1989/1990 2000/2001, occurred between 2002 2008. related (Δ-values)...
Background: Plant-based diets are recommended to lower the risk of type 2 diabetes (T2D) and coronary heart disease (CHD). Proteomic responses plant-based may reveal biological pathways underlying associations between cardiometabolic risk. Hypothesis: profiles reflecting adherence response an overall diet index (PDI) a healthy PDI (hPDI) will associate with risks T2D CHD, but unhealthy (uPDI) higher risks. Methods: We analyzed baseline plasma Olink antibody-based proteomic profiling food...
Introduction: Puerto Ricans on the US mainland have poor diet quality linked to adverse cardiometabolic risk, but underlying mechanisms are unclear. Hypothesis: Plasma metabolomic signatures reflect Rican patterns and associated with risk independent of diet. Methods: We used LC/MS measure 714 plasma metabolites in 722 participants (45-75 y) [n=372 type 2 diabetes (T2D); n=346 without T2D; n=4 T2D missing] Boston Health Study. Diet was assessed using an ethnic-specific validated food...
Abstract Background: The impact of diet on breast cancer survival remains inconclusive. We assessed associations all-cause mortality with adherence to the four quality indices: Healthy Eating Index-2015 (HEI-2015), Alternative Index (AHEI), Mediterranean Diet (aMED), and Dietary Approaches Stop Hypertension (DASH). Methods: intake data were evaluated for 6,157 North American women enrolled in Breast Cancer Family Registry who had been diagnosed invasive from 1993 2011 followed through 2018....
Evidence from cohort studies indicates a bidirectional relationship between periodontal disease and type 2 diabetes (T2D), but the underlying mechanisms remain unknown. In this study, we aimed to (1) identify saliva, plasma, multifluid metabolomic signatures associated with (2) determine if these predict T2D progression cardiometabolic biomarkers at year 3.
(1) Background: Branched-chain and aromatic amino acids (BCAAs/AAAs) have been considered as markers of type 2 diabetes (T2D); however, studies on associations between these metabolites T2D cardiometabolic traits in Hispanic populations are limited. The aim this study was to examine the baseline BCAAs (isoleucine, leucine, valine)/AAAs (phenylalanine, tyrosine) prevalent incident T2D, well longitudinal (2 year) changes (measures glycemia, dyslipidemia, inflammation, obesity) two large...
Purpose: Scientific evidence suggests a role for lutein and zeaxanthin, in visual function. The purpose of this research was to summarize the data related lutein/zeaxanthin intake outcomes adults with healthy eyes using mapping methods describe date that would be useful guiding future priorities, systematic reviews, meta-analyses. Design: A search Medline®, Cochrane Central, CAB databases performed studies all designs published from 1946 October 2016. Our strategy included lutein,...
Prospective cohort studies have found a relation between sugar-sweetened beverage consumption (SSB; sodas and fruit drinks) dyslipidemia. There is limited evidence linking SSB to emerging features of dyslipidemia, which can be characterized by variation in lipoprotein particle size, remnant-like (RLP), apolipoprotein concentrations.To examine the association plasma cholesterol, apolipoprotein, size concentrations among US adults.We examined participants from Framingham Offspring Study (FOS)...
ChREBP (carbohydrate responsive element binding protein) is a transcription factor that responds to sugar consumption. Sugar-sweetened beverage (SSB) consumption and genetic variants in the CHREBP locus have separately been linked HDL-C (high-density lipoprotein cholesterol) triglyceride concentrations. We hypothesized SSB would modify association between dyslipidemia.Data from 11 cohorts Cohorts for Heart Aging Research Genomic Epidemiology consortium (N=63 599) UK Biobank (N=59 220) were...
We examined whether intake of methyl donor nutrients, including vitamins B2, B6, and B12 folate, from foods and/or supplements is associated with type 2 diabetes risk.