A5001869722- Genetic Associations and Epidemiology
- Nutrition, Genetics, and Disease
- Cognitive Abilities and Testing
- Intergenerational and Educational Inequality Studies
- Birth, Development, and Health
- Demographic Trends and Gender Preferences
- Bioinformatics and Genomic Networks
- Folate and B Vitamins Research
- Genetic Mapping and Diversity in Plants and Animals
- BRCA gene mutations in cancer
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Liver Disease Diagnosis and Treatment
- Bipolar Disorder and Treatment
- Obesity, Physical Activity, Diet
- Eating Disorders and Behaviors
- Schizophrenia research and treatment
- Diet and metabolism studies
- Nutritional Studies and Diet
- Diet, Metabolism, and Disease
- Adolescent and Pediatric Healthcare
Erasmus University Rotterdam
2015-2023
Vrije Universiteit Amsterdam
2018-2022
University of Oxford
2022
Leverhulme Trust
2022
Amsterdam Neuroscience
2018
Cognitive Research (United States)
2018
University of Amsterdam
2015
Understanding which biological pathways are specific versus general across diagnostic categories and levels of symptom severity is critical to improving nosology treatment psychopathology. Here, we combine transdiagnostic dimensional approaches genetic discovery for the first time, conducting a novel multivariate genome-wide association study eight psychiatric symptoms disorders broadly related mood disturbance psychosis. We identify two liabilities that distinguish between common forms...
Abstract We conducted genome-wide association studies (GWAS) of relative intake from the macronutrients fat, protein, carbohydrates, and sugar in over 235,000 individuals European ancestries. identified 21 unique, approximately independent lead SNPs. Fourteen SNPs are uniquely associated with one macronutrient at significance ( P < 5 × 10 −8 ), while five reach suggestive 1 −5 ) for least other macronutrient. While phenotypes genetically correlated, each phenotype carries a partially...
Abstract Dietary factors are assumed to play an important role in cancer risk, apparent consensus recommendations for prevention that promote nutritional changes. However, the evidence this field has been generated predominantly through observational studies, which may result biased effect estimates because of confounding, exposure misclassification, and reverse causality. With major geographical differences rapid changes incidence over time, it is crucial establish associations reflect...
Abstract Understanding which biological pathways are specific versus general across diagnostic categories and levels of symptom severity is critical to improving nosology treatment psychopathology. Here, we combine transdiagnostic dimensional approaches genetic discovery for the first time, conducting a novel multivariate genome-wide association study (GWAS) eight psychiatric symptoms disorders broadly related mood disturbance psychosis. We identify two liabilities that distinguish between...
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Abstract We conducted genome-wide association study (GWAS) meta-analyses of relative caloric intake from fat, protein, carbohydrates and sugar in over 235,000 individuals. identified 21 approximately independent lead SNPs. Relative protein exhibits the strongest relationships with poor health, including positive genetic associations obesity, type 2 diabetes, heart disease ( r g ≈ 0.15 – 0.5). carbohydrate have negative correlations waist circumference, waist-hip ratio, neighborhood poverty...
We conducted a genome-wide association study of subjective well-being (SWB) in 298,420 individuals. also performed auxiliary analyses depressive symptoms ("DS"; N = 161,460) and neuroticism ( 170,910), both which have substantial genetic correlation with SWB ρ ≈-0.8). identify three SNPs associated at significance. Two them are significantly DS an independent sample. In our analyses, we 13 additional genome-wide-significant associations: two eleven neuroticism, including inversion...
ABSTRACT Measurement error in polygenic indices (PGIs) attenuates the estimation of their effects regression models. While this measurement shrinks with growing Genome-wide Association Study (GWAS) sample sizes, marginal returns to bigger sizes are rapidly decreasing. We analyze and compare two alternative approaches reduce error: Obviously Related Instrumental Variables (ORIV) PGI Repository Correction (PGI-RC). Through simulations, we show that both outperform typical (meta-analysis based)...
This paper shows how nature (i.e., one's genetic endowments) and nurture environment) interact in producing educational attainment. Genetic endowments are measured using a polygenic score for attainment, while we use birth order as an important environmental determinant of Since randomly assigned within-families orthogonal to order, our family fixed effects approach exploits exogenous variation well environments. We find that those with higher benefit disproportionally more from being...
Abstract Polygenic indices (PGIs) are increasingly used to identify individuals at high risk of developing diseases and disorders advocated as a screening tool for personalised intervention in medicine education. The performance PGIs is typically assessed terms the amount phenotypic variance they explain independent prediction samples. However, correct ranking PGI distribution more important metric when identifying genetic risk. We empirically assess rank concordance between that created...
Dietary factors are assumed to play an important role in cancer risk, apparent consensus recommendations for prevention that promote nutritional changes. However, the evidence this field has been generated predominantly through observational studies, which may result biased effect estimates because of confounding, exposure misclassification, and reverse causality. With major geographical differences rapid changes incidence over time, it is crucial establish associations reflect causality...