Michel G. Nivard
- Genetic Associations and Epidemiology
- Cognitive Abilities and Testing
- Genetic Mapping and Diversity in Plants and Animals
- Birth, Development, and Health
- Child and Adolescent Psychosocial and Emotional Development
- Genetics and Neurodevelopmental Disorders
- Epigenetics and DNA Methylation
- Genetic and phenotypic traits in livestock
- Health, Environment, Cognitive Aging
- Bioinformatics and Genomic Networks
- Mental Health Research Topics
- Autism Spectrum Disorder Research
- Health disparities and outcomes
- Nutrition, Genetics, and Disease
- Genomics and Rare Diseases
- Cannabis and Cannabinoid Research
- Attention Deficit Hyperactivity Disorder
- Obesity, Physical Activity, Diet
- Genomic variations and chromosomal abnormalities
- Dementia and Cognitive Impairment Research
- Metabolomics and Mass Spectrometry Studies
- Genetic Syndromes and Imprinting
- Adolescent and Pediatric Healthcare
- Alzheimer's disease research and treatments
- Bipolar Disorder and Treatment
Vrije Universiteit Amsterdam
2016-2025
Amsterdam University Medical Centers
2019-2025
University of Bristol
2024-2025
MRC Epidemiology Unit
2025
Medical Research Council
2025
Amsterdam Public Health
2017-2024
Public Health Service of Amsterdam
2019-2022
University of Amsterdam
2018-2022
Amsterdam Neuroscience
2013-2022
Universities UK
2022
Summary While many disease-associated variants have been identified through genome-wide association studies, their downstream molecular consequences remain unclear. To identify these effects, we performed cis- and trans-expression quantitative trait locus (eQTL) analysis in blood from 31,684 individuals the eQTLGen Consortium. We observed that cis -eQTLs can be detected for 88% of studied genes, but they a different genetic architecture compared to variants, limiting our ability use pinpoint...
The genetics of sexual orientation Twin studies and other analyses inheritance in humans has indicated that same-sex behavior a genetic component. Previous searches for the specific genes involved have been underpowered thus unable to detect signals. Ganna et al. perform genome-wide association study on 493,001 participants from United States, Kingdom, Sweden associated with (see Perspective by Mills). They find multiple loci implicated indicating that, like behavioral traits,...
Abstract The methylome is subject to genetic and environmental effects. Their impact may depend on sex age, resulting in sex- age-related physiological variation disease susceptibility. Here we estimate the total heritability of DNA methylation levels whole blood variance explained by common single nucleotide polymorphisms at 411,169 sites 2,603 individuals from twin families, establish a catalogue between-individual methylation. Heritability estimates vary across genome (mean=19%)...
Abstract Estimates from Mendelian randomization studies of unrelated individuals can be biased due to uncontrolled confounding familial effects. Here we describe methods for within-family analyses and use simulation show that family-based reduce such biases. We illustrate empirically how effects affect estimates using data 61,008 siblings the Nord-Trøndelag Health Study UK Biobank replicated our findings 222,368 23andMe. Both within family reproduced established lower BMI reducing risk...
In this paper we elaborate on the potential of lmer function from <b>lme4</b> package in <b>R</b> for item response (IRT) modeling. line with package, an IRT framework is described based generalized linear mixed The aspects refer to (a) kind covariates -- their mode (person, item, person-by-item), and being external vs. internal responses, (b) effects have fixed random, if across which are random (persons, items). Based framework, three broad categories models described: Item covariate...
Estimates from genome-wide association studies (GWAS) of unrelated individuals capture effects inherited variation (direct effects), demography (population stratification, assortative mating) and relatives (indirect genetic effects). Family-based GWAS designs can control for demographic indirect effects, but large-scale family datasets have been lacking. We combined data 178,086 siblings 19 cohorts to generate population (between-family) within-sibship (within-family) estimates 25...
Abstract Genome-wide association studies (GWAS) have identified thousands of variants associated with complex traits, but their biological interpretation often remains unclear. Most these overlap expression QTLs, indicating potential involvement in regulation gene expression. Here, we propose a transcriptome-wide summary statistics-based Mendelian Randomization approach (TWMR) that uses multiple SNPs as instruments and traits exposures, simultaneously. Applied to 43 human phenotypes, it...
We use a genome-wide association of 1 million parental lifespans genotyped subjects and data on mortality risk factors to validate previously unreplicated findings near CDKN2B-AS1, ATXN2/BRAP, FURIN/FES, ZW10, PSORS1C3, 13q21.31, identify replicate novel ABO, ZC3HC1, IGF2R. also previous 5q33.3/EBF1 FOXO3, whilst finding contradictory evidence at other loci. Gene set cell-specific analyses show that expression in foetal brain cells adult dorsolateral prefrontal cortex is enriched for...