Michel G. Nivard

ORCID: 0000-0003-2015-1888
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About
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Research Areas
  • Genetic Associations and Epidemiology
  • Cognitive Abilities and Testing
  • Genetic Mapping and Diversity in Plants and Animals
  • Birth, Development, and Health
  • Child and Adolescent Psychosocial and Emotional Development
  • Genetics and Neurodevelopmental Disorders
  • Epigenetics and DNA Methylation
  • Genetic and phenotypic traits in livestock
  • Health, Environment, Cognitive Aging
  • Bioinformatics and Genomic Networks
  • Mental Health Research Topics
  • Autism Spectrum Disorder Research
  • Health disparities and outcomes
  • Nutrition, Genetics, and Disease
  • Genomics and Rare Diseases
  • Cannabis and Cannabinoid Research
  • Attention Deficit Hyperactivity Disorder
  • Obesity, Physical Activity, Diet
  • Genomic variations and chromosomal abnormalities
  • Dementia and Cognitive Impairment Research
  • Metabolomics and Mass Spectrometry Studies
  • Genetic Syndromes and Imprinting
  • Adolescent and Pediatric Healthcare
  • Alzheimer's disease research and treatments
  • Bipolar Disorder and Treatment

Vrije Universiteit Amsterdam
2016-2025

Amsterdam University Medical Centers
2019-2025

University of Bristol
2024-2025

MRC Epidemiology Unit
2025

Medical Research Council
2025

Amsterdam Public Health
2017-2024

Public Health Service of Amsterdam
2019-2022

University of Amsterdam
2018-2022

Amsterdam Neuroscience
2013-2022

Universities UK
2022

Phil H. Lee Verneri Anttila Hyejung Won Yen‐Chen Anne Feng Jacob Rosenthal and 95 more Zhaozhong Zhu Elliot M. Tucker‐Drob Michel G. Nivard Andrew D. Grotzinger Daniëlle Posthuma Meg M.-J. Wang Dongmei Yu Eli A. Stahl Raymond K. Walters Richard Anney Laramie E. Duncan Tian Ge Rolf Adolfsson Tobias Banaschewski Síntia Belangero Edwin H. Cook Giovanni Coppola Eske M. Derks Pieter J. Hoekstra Jaakko Kaprio Anna Keski‐Rahkonen George Kirov Henry R. Kranzler Jurjen J. Luykx Luís Augusto Rohde Clement C. Zai Esben Agerbo María J. Arranz Philip Asherson Marie Bækvad‐Hansen Gísli Baldursson Mark A. Bellgrove Richard A. Belliveau Jan K. Buitelaar Christie L. Burton Jonas Bybjerg‐Grauholm Miguel Casas Felecia Cerrato Kimberly Chambert Tracy Air Bru Cormand Jennifer Crosbie Søren Dalsgaard Ditte Demontis Alysa E. Doyle Ashley Dumont Josephine Elia Jakob Grove Ólafur Ó. Guðmundsson Jan Haavik Håkon Håkonarson Christine Søholm Hansen Catharina A. Hartman Ziarih Hawi Amaia Hervás David M. Hougaard Daniel P. Howrigan Hailiang Huang Jonna Kuntsi K. Langley Klaus‐Peter Lesch Patrick W. L. Leung Sandra K. Loo Joanna Martin Alicia R. Martin James J. McGough Sarah E. Medland Jennifer L. Moran Ole Mors Preben Bo Mortensen Robert D. Oades Duncan S. Palmer Carsten Bøcker Pedersen Marianne G. Pedersen Triinu Peters Timothy Poterba Jesper Buchhave Poulsen Josep Antoni Ramos‐Quiroga Andreas Reif Marta Ribasés Aribert Rothenberger Paula Rovira Cristina Sánchez‐Mora F. Kyle Satterstrom Russell Schachar María Soler Artigas Stacy Steinberg Hreinn Stefánsson Patrick Turley G. Bragi Walters Thomas Werge Tetyana Zayats Dan E. Arking Francesco Bettella Joseph D. Buxbaum

10.1016/j.cell.2019.11.020 article EN publisher-specific-oa Cell 2019-12-01
Urmo Võsa Annique Claringbould Harm-Jan Westra Marc Jan Bonder Patrick Deelen and 95 more Biao Zeng Holger Kirsten Ashis Saha Roman Kreuzhuber Seyhan Yazar Harm Brugge Roy Oelen Dylan H. de Vries Monique G.P. van der Wijst Silva Kasela Natalia Pervjakova Isabel Alves Marie-Julie Favé Mawussé Agbessi Mark Christiansen Rick Jansen Ilkka Seppälä Tong Lin Alexander Teumer Katharina Schramm Gibran Hemani Joost Verlouw Hanieh Yaghootkar Reyhan Sönmez Flitman Andrew Brown Viktorija Kukushkina Anette Kalnapenkis Sina Rüeger Eleonora Porcu Jaanika Kronberg Johannes Kettunen Bernett Lee Futao Zhang Ting Qi José Alquicira-Hernández Wibowo Arindrarto Frank Beutner Peter A.C. ’t Hoen Joyce B. J. van Meurs Jenny van Dongen Maarten van Iterson Morris A. Swertz Marc Jan Bonder Julia Dmitrieva Mahmoud Elansary Benjamin P. Fairfax Michel Georges Bastiaan T. Heijmans Alex W. Hewitt Mika Kähönen Yungil Kim Julian C. Knight Péter Kovács Knut Krohn Shuang� Li Markus Loeffler Urko M. Marigorta Hailang Mei Yukihide Momozawa Martina Müller‐Nurasyid Matthias Nauck Michel G. Nivard Brenda W.J.H. Penninx Jonathan K. Pritchard Olli T. Raitakari Olaf Rötzschke P. Eline Slagboom Coen D.A. Stehouwer Michael Stümvoll Patrick Sullivan Peter A.C. ’t Hoen Joachim Thiery Anke Tönjes Jenny van Dongen Maarten van Iterson Jan H. Veldink Uwe Völker Robert Warmerdam Cisca Wijmenga Morris A. Swertz Anand Kumar Andiappan Grant W. Montgomery Samuli Ripatti Markus Perola Zoltán Kutalik Emmanouil T. Dermitzakis Sven Bergmann Timothy M. Frayling Joyce B. J. van Meurs Holger Prokisch Habibul Ahsan Brandon L. Pierce Terho Lehtimäki Dorret I. Boomsma Bruce M. Psaty

10.1038/s41588-021-00913-z article EN Nature Genetics 2021-09-01
Aysu Okbay Bart M. L. Baselmans Jan-Emmanuel De Neve Patrick Turley Michel G. Nivard and 95 more Mark Alan Fontana S Fleur W Meddens Richard Karlsson Linnér Cornelius A. Rietveld Jaime Derringer Jacob Gratten James J. Lee Jimmy Z. Liu Ronald de Vlaming Tarunveer S. Ahluwalia Jadwiga Buchwald Alana Cavadino Alexis C. Wood Nicholas A. Furlotte Victoria Garfield Marie Henrike Geisel Juan R Gonzalez Saskia Haitjema Robert Karlsson Sander W. van der Laan Karl-Heinz Ladwig Jari Lahti Sven J. van der Lee Penelope A. Lind Tian Liu Lindsay Matteson Evelin Mihailov Michael Miller Camelia C. Minică Ilja M. Nolte Dennis O. Mook‐Kanamori Peter J. van der Most Christopher Oldmeadow Yong Qian Olli Raitakari Rajesh Rawal Anu Realo Rico Rueedi Börge Schmidt Albert V. Smith Evie Stergiakouli Toshiko Tanaka Kent D. Taylor Gudmar Thorleifsson Juho Wedenoja Juergen Wellmann Harm-Jan Westra Sara M. Willems Wei Zhao Najaf Amin Andrew Bakshi Sven Bergmann Gyða Björnsdóttir Patricia A. Boyle Samantha Cherney Simon R. Cox Gail Davies Oliver S. P. Davis Jun Ding Neşe Direk Peter Eibich Rebecca T. Emeny Ghazaleh Fatemifar Jessica D. Faul Luigi Ferrucci Andreas J. Forstner Christian Gieger Richa Gupta Tamara B Harris Juliette Harris Elizabeth G. Holliday Jouke-Jan Hottenga Philip L De Jager Marika Kaakinen Eero Kajantie Ville Karhunen Ivana Kolčić Meena Kumari Lenore J Launer Lude Franke Ruifang Li‐Gao David C. Liewald Marisa Koini Anu Loukola Pedro Marques‐Vidal Grant W. Montgomery Miriam A. Mosing Lavinia Paternoster Alison Pattie Katja Petrovic Laura Pulkki-Råback Lydia Quaye Katri Räikkönen Igor Rudan Rodney J. Scott

10.1038/ng.3552 article EN Nature Genetics 2016-04-18
Urmo Võsa Annique Claringbould Harm-Jan Westra Marc Jan Bonder Patrick Deelen and 95 more Biao Zeng Holger Kirsten Ashis Saha Roman Kreuzhuber Silva Kasela Natalia Pervjakova Isabel Alvaes Marie-Julie Favé Mawussé Agbessi Mark Christiansen Rick Jansen Ilkka Seppälä Tong Lin Alexander Teumer Katharina Schramm Gibran Hemani Joost Verlouw Hanieh Yaghootkar Reyhan Sönmez Andrew Brown Viktorija Kukushkina Anette Kalnapenkis Sina Rüeger Eleonora Porcu Jaanika Kronberg-Guzman Johannes Kettunen Joseph E. Powell Bernett Lee Futao Zhang Wibowo Arindrarto Frank Beutner Harm Brugge Julia Dmitreva Mahmoud Elansary Benjamin P. Fairfax Michel Georges Bastiaan T. Heijmans Mika Kähönen Yungil Kim Julian C. Knight Péter Kovács Knut Krohn Shuang� Li Markus Loeffler Urko M. Marigorta Hailang Mei Yukihide Momozawa Martina Müller‐Nurasyid Matthias Nauck Michel G. Nivard Brenda W.J.H. Penninx Jonathan K. Pritchard Olli T. Raitakari Olaf Rotzchke P. Eline Slagboom Coen D.A. Stehouwer Michael Stümvoll Patrick Sullivan Peter A.C. ’t Hoen Joachim Thiery Anke Tönjes Jenny van Dongen Maarten van Iterson Jan H. Veldink Uwe Völker Cisca Wijmenga Morris A. Swertz Anand Kumar Andiappan Grant W. Montgomery Samuli Ripatti Markus Perola Zoltán Kutalik Emmanouil T. Dermitzakis Sven Bergmann Timothy M. Frayling Joyce B. J. van Meurs Holger Prokisch Habibul Ahsan Brandon L. Pierce Terho Lehtimäki Dorret I. Boomsma Bruce M. Psaty Sina A. Gharib Philip Awadalla Lili Milani Willem H. Ouwehand Kate Downes Oliver Stegle Alexis Battle Jian Yang Peter M. Visscher Markus Scholz Gregory Gibson Tõnu Esko Lude Franke

Summary While many disease-associated variants have been identified through genome-wide association studies, their downstream molecular consequences remain unclear. To identify these effects, we performed cis- and trans-expression quantitative trait locus (eQTL) analysis in blood from 31,684 individuals the eQTLGen Consortium. We observed that cis -eQTLs can be detected for 88% of studied genes, but they a different genetic architecture compared to variants, limiting our ability use pinpoint...

10.1101/447367 preprint EN bioRxiv (Cold Spring Harbor Laboratory) 2018-10-19

The genetics of sexual orientation Twin studies and other analyses inheritance in humans has indicated that same-sex behavior a genetic component. Previous searches for the specific genes involved have been underpowered thus unable to detect signals. Ganna et al. perform genome-wide association study on 493,001 participants from United States, Kingdom, Sweden associated with (see Perspective by Mills). They find multiple loci implicated indicating that, like behavioral traits,...

10.1126/science.aat7693 article EN Science 2019-08-29

Abstract The methylome is subject to genetic and environmental effects. Their impact may depend on sex age, resulting in sex- age-related physiological variation disease susceptibility. Here we estimate the total heritability of DNA methylation levels whole blood variance explained by common single nucleotide polymorphisms at 411,169 sites 2,603 individuals from twin families, establish a catalogue between-individual methylation. Heritability estimates vary across genome (mean=19%)...

10.1038/ncomms11115 article EN cc-by Nature Communications 2016-04-07

Abstract Estimates from Mendelian randomization studies of unrelated individuals can be biased due to uncontrolled confounding familial effects. Here we describe methods for within-family analyses and use simulation show that family-based reduce such biases. We illustrate empirically how effects affect estimates using data 61,008 siblings the Nord-Trøndelag Health Study UK Biobank replicated our findings 222,368 23andMe. Both within family reproduced established lower BMI reducing risk...

10.1038/s41467-020-17117-4 article EN cc-by Nature Communications 2020-07-14

In this paper we elaborate on the potential of lmer function from <b>lme4</b> package in <b>R</b> for item response (IRT) modeling. line with package, an IRT framework is described based generalized linear mixed The aspects refer to (a) kind covariates -- their mode (person, item, person-by-item), and being external vs. internal responses, (b) effects have fixed random, if across which are random (persons, items). Based framework, three broad categories models described: Item covariate...

10.18637/jss.v039.i12 article EN cc-by Journal of Statistical Software 2011-01-01
Laurence J Howe Michel G. Nivard Tim Morris Ailin Falkmo Hansen Humaira Rasheed and 95 more Yoonsu Cho Geetha Chittoor Rafael Ahlskog Penelope A. Lind Teemu Palviainen Matthijs D. van der Zee Rosa Cheesman Massimo Mangino Yunzhang Wang Shuai Li Lucija Klarić Scott M. Ratliff Lawrence F. Bielak Marianne Nygaard Alexandros Giannelis Emily A. Willoughby Chandra A. Reynolds Jared V. Balbona Ole A. Andreassen Helga Ask Aris Baras Christopher R. Bauer Dorret I. Boomsma Archie Campbell Harry Campbell Zhengming Chen Paraskevi Christofidou Elizabeth C. Corfield Christina C. Dahm Deepika Dokuru Luke M. Evans Eco J. C. de Geus Sudheer Giddaluru Scott D. Gordon K. Paige Harden W. David Hill Amanda Hughes Shona M. Kerr Yongkang Kim Hyeokmoon Kweon Antti Latvala Debbie A. Lawlor Liming Li Kuang Lin Per Magnus Patrik K. E. Magnusson Travis T. Mallard Pekka Martikainen Melinda Mills Pål R. Njølstad John D. Overton Nancy L. Pedersen David J. Porteous Jeffrey G. Reid Karri Silventoinen Melissa C. Southey Camilla Stoltenberg Elliot M. Tucker‐Drob Margaret J. Wright Hyeokmoon Kweon Philipp Koellinger Daniel J. Benjamin Patrick Turley Laurence J Howe Michel G. Nivard Tim Morris Ailin Falkmo Hansen Humaira Rasheed Yoonsu Cho Geetha Chittoor Rafael Ahlskog Penelope A. Lind Teemu Palviainen Matthijs D. van der Zee Rosa Cheesman Massimo Mangino Yunzhang Wang Shuai Li Lucija Klarić Scott M. Ratliff Lawrence F. Bielak Marianne Nygaard Alexandros Giannelis Emily A. Willoughby Chandra A. Reynolds Jared V. Balbona Ole A. Andreassen Helga Ask Dorret I. Boomsma Archie Campbell Harry Campbell Zhengming Chen Paraskevi Christofidou Elizabeth C. Corfield Christina C. Dahm

Estimates from genome-wide association studies (GWAS) of unrelated individuals capture effects inherited variation (direct effects), demography (population stratification, assortative mating) and relatives (indirect genetic effects). Family-based GWAS designs can control for demographic indirect effects, but large-scale family datasets have been lacking. We combined data 178,086 siblings 19 cohorts to generate population (between-family) within-sibship (within-family) estimates 25...

10.1038/s41588-022-01062-7 article EN cc-by Nature Genetics 2022-05-01
Eleonora Porcu Sina Rüeger Kaido Lepik Mawussé Agbessi Habibul Ahsan and 95 more Isabel Alves Anand Kumar Andiappan Wibowo Arindrarto Philip Awadalla Alexis Battle Frank Beutner Marc Jan Bonder Dorret I. Boomsma Mark Christiansen Annique Claringbould Patrick Deelen Tõnu Esko Marie-Julie Favé Lude Franke Timothy M. Frayling Sina A. Gharib Gregory Gibson Bastiaan T. Heijmans Gibran Hemani Rick Jansen Mika Kähönen Anette Kalnapenkis Silva Kasela Johannes Kettunen Yungil Kim Holger Kirsten Péter Kovács Knut Krohn Jaanika Kronberg-Guzman Viktorija Kukushkina Bernett Lee Terho Lehtimäki Markus Loeffler Urko M. Marigorta Hailang Mei Lili Milani Grant W. Montgomery Martina Müller‐Nurasyid Matthias Nauck Michel G. Nivard Brenda W.J.H. Penninx Markus Perola Natalia Pervjakova Brandon L. Pierce Joseph E. Powell Holger Prokisch Bruce M. Psaty Olli T. Raitakari Samuli Ripatti Olaf Rötzschke Ashis Saha Markus Scholz Katharina Schramm Ilkka Seppälä P. Eline Slagboom Coen D.A. Stehouwer Michael Stümvoll Patrick Sullivan Peter A.C. ’t Hoen Alexander Teumer Joachim Thiery Tong Lin Anke Tönjes Jenny van Dongen Maarten van Iterson Joyce B. J. van Meurs Jan H. Veldink Joost Verlouw Peter M. Visscher Uwe Völker Urmo Võsa Harm-Jan Westra Cisca Wijmenga Hanieh Yaghootkar Jian Yang Biao Zeng Futao Zhang Wibowo Arindrarto Marian Beekman Dorret I. Boomsma Jan Bot Joris Deelen Patrick Deelen Lude Franke Bastiaan T. Heijmans Peter A.C. ’t Hoen Bert A. Hofman Jouke‐Jan Hottenga Aaron Isaacs Marc Jan Bonder P. Mila Jhamai Rick Jansen Szymon M. Kiełbasa Nico Lakenberg René Luijk

Abstract Genome-wide association studies (GWAS) have identified thousands of variants associated with complex traits, but their biological interpretation often remains unclear. Most these overlap expression QTLs, indicating potential involvement in regulation gene expression. Here, we propose a transcriptome-wide summary statistics-based Mendelian Randomization approach (TWMR) that uses multiple SNPs as instruments and traits exposures, simultaneously. Applied to 43 human phenotypes, it...

10.1038/s41467-019-10936-0 article EN cc-by Nature Communications 2019-07-24
Paul R. H. J. Timmers Ninon Mounier Kristi Läll Krista Fischer Ning Zheng and 95 more Xiao Feng Andrew D. Bretherick David W. Clark Mawussé Agbessi Habibul Ahsan Isabel Alves Anand Kumar Andiappan Philip Awadalla Alexis Battle Marc Jan Bonder Dorret I. Boomsma Mark Christiansen Annique Claringbould Patrick Deelen Jenny van Dongen Tõnu Esko Marie‐Julie Favé Lude Franke T Frayling Sina A. Gharib Greg Gibson Gibran Hemani Rick Jansen A Kalnapenkis Silva Kasela Jarno L. T. Kettunen Y Kim Holger Kirsten Péter Kovács Knut Krohn Jaanika Kronberg-Guzman Viktorija Kukushkina Zoltán Kutalik Mika Kähönen B Lee Terho Lehtimäki Markus Loeffler Urko M. Marigorta Andres Metspalu Joyce B. J. van Meurs Lili Milani Martina Müller‐Nurasyid Matthias Nauck Michel G. Nivard Brenda W.J.H. Penninx Markus Perola Natalia Pervjakova Brandon L. Pierce Joseph E. Powell Holger Prokisch BM Psaty Olli Raitakari Susan M. Ring Samuli Ripatti Olaf Rötzschke Sina Rüeger A Saha Markus Scholz Katharina Schramm Ilkka Seppälä Michael Stümvoll Patrick F. Sullivan Alexander Teumer Joachim Thiery Tong Lin Anke Tönjes Joost Verlouw Peter M. Visscher Urmo Võsa Uwe Völker Hanieh Yaghootkar Jian Yang Biao Zeng F Zhang Mawussé Agbessi Habibul Ahsan Isabel Alves Anand Kumar Andiappan Philip Awadalla Alexis Battle Marc Jan Bonder Dorret I. Boomsma Mark Christiansen Annique Claringbould Patrick Deelen Jenny van Dongen Tõnu Esko Marie‐Julie Favé Lude Franke T Frayling Sina A. Gharib Greg Gibson Gibran Hemani Rick Jansen A Kalnapenkis

We use a genome-wide association of 1 million parental lifespans genotyped subjects and data on mortality risk factors to validate previously unreplicated findings near CDKN2B-AS1, ATXN2/BRAP, FURIN/FES, ZW10, PSORS1C3, 13q21.31, identify replicate novel ABO, ZC3HC1, IGF2R. also previous 5q33.3/EBF1 FOXO3, whilst finding contradictory evidence at other loci. Gene set cell-specific analyses show that expression in foetal brain cells adult dorsolateral prefrontal cortex is enriched for...

10.7554/elife.39856 article EN cc-by eLife 2019-01-15
Melinda Mills Felix C. Tropf David M. Brazel Natalie R. van Zuydam Ahmad Vaez and 95 more Mawussé Agbessi Habibul Ahsan Isabel Alves Anand Kumar Andiappan Wibowo Arindrarto Philip Awadalla Alexis Battle Frank Beutner Marc Jan Bonder Dorret I. Boomsma Mark Christiansen Annique Claringbould Patrick Deelen Tõnu Esko Marie-Julie Favé Lude Franke Timothy M. Frayling Sina A. Gharib Greg Gibson Bastiaan T. Heijmans Gibran Hemani Rick Jansen Mika Kähönen Anette Kalnapenkis Silva Kasela Johannes Kettunen Yungil Kim Holger Kirsten Péter Kovács Knut Krohn Jaanika Kronberg Viktorija Kukushkina Zoltán Kutalik Bernett Lee Terho Lehtimäki Markus Loeffler Urko M. Marigorta Hailang Mei Lili Milani Grant W. Montgomery Martina Müller‐Nurasyid Matthias Nauck Michel G. Nivard Brenda W.J.H. Penninx Markus Perola Natalia Pervjakova Brandon L. Pierce Joseph E. Powell Holger Prokisch Bruce M. Psaty Olli T. Raitakari Samuli Ripatti Olaf Rötzschke Sina Rüeger Ashis Saha Markus Scholz Katharina Schramm Ilkka Seppälä P. Eline Slagboom Coen D.A. Stehouwer Michael Stümvoll Patrick Sullivan Peter A.C. ’t Hoen Alexander Teumer Joachim Thiery Tong Lin Anke Tönjes Jenny van Dongen Maarten van Iterson Joyce B. J. van Meurs Jan H. Veldink Joost Verlouw Peter M. Visscher Uwe Völker Urmo Võsa Harm-Jan Westra Cisca Wijmenga Hanieh Yaghootkar Jian Yang Biao Zeng Futao Zhang Bastiaan T. Heijmans Peter A.C. ’t Hoen Joyce B. J. van Meurs Aaron Isaacs Rick Jansen Lude Franke Dorret I. Boomsma René Pool Jenny van Dongen Jouke‐Jan Hottenga Marleen M. J. van Greevenbroek Coen D.A. Stehouwer Carla Kallen Casper G. Schalkwijk

10.1038/s41562-021-01135-3 article EN Nature Human Behaviour 2021-07-01
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