Fernando Pires Hartwig
A5087114182- Genetic Associations and Epidemiology
- Genetic and phenotypic traits in livestock
- Birth, Development, and Health
- Sperm and Testicular Function
- Genetic Mapping and Diversity in Plants and Animals
- SARS-CoV-2 and COVID-19 Research
- Advanced Causal Inference Techniques
- COVID-19 Clinical Research Studies
- Reproductive Biology and Fertility
- Breastfeeding Practices and Influences
- Epigenetics and DNA Methylation
- Telomeres, Telomerase, and Senescence
- Child Nutrition and Water Access
- SARS-CoV-2 detection and testing
- Global Maternal and Child Health
- Nutrition, Genetics, and Disease
- Health, Environment, Cognitive Aging
- Education during COVID-19 pandemic
- Obesity, Physical Activity, Diet
- Reproductive Physiology in Livestock
- Vaccine Coverage and Hesitancy
- Statistical Methods in Clinical Trials
- COVID-19 and Mental Health
- Nutritional Studies and Diet
- Seed Germination and Physiology
Universidade Federal de Pelotas
2016-2025
Medical Research Council
2016-2025
University of Bristol
2016-2025
MRC Epidemiology Unit
2017-2024
University of Chicago
2023
Erasmus MC
2023
NIHR Bristol Biomedical Research Centre
2022
Universidade Estadual Paulista (Unesp)
2012-2020
MRC Integrative Epidemiology Unit
2016-2017
University of Rostock
2014
Mendelian randomization (MR) is being increasingly used to strengthen causal inference in observational studies. Availability of summary data genetic associations for a variety phenotypes from large genome-wide association studies (GWAS) allows straightforward application MR using methods, typically two-sample design. In addition the conventional inverse variance weighting (IVW) method, recently developed such as MR-Egger and weighted median approaches, allow relaxation instrumental variable...
<ns4:p>This paper provides guidelines for performing Mendelian randomization investigations. It is aimed at practitioners seeking to undertake analyses and write up their findings, journal editors reviewers assess manuscripts. The are divided into nine sections: motivation scope, data sources, choice of genetic variants, variant harmonization, primary analysis, supplementary sensitivity (one section on robust methods one other approaches), presentation, interpretation. These will be updated...
<ns4:p>This paper provides guidelines for performing Mendelian randomization investigations. It is aimed at practitioners seeking to undertake analyses and write up their findings, journal editors reviewers assess manuscripts. The are divided into nine sections: motivation scope, data sources, choice of genetic variants, variant harmonization, primary analysis, supplementary sensitivity (one section on robust statistical methods one other approaches), presentation, interpretation. These will...
Population-based data on COVID-19 are essential for guiding policies. There few such studies, particularly from low or middle-income countries. Brazil is currently a hotspot globally. We aimed to investigate severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibody prevalence by city and according sex, age, ethnicity group, socioeconomic status, compare seroprevalence estimates with official statistics deaths cases.In this repeated cross-sectional study, we did two surveys in 133...
<ns3:p>This paper provides guidelines for performing Mendelian randomization investigations. It is aimed at practitioners seeking to undertake analyses and write up their findings, journal editors reviewers assess manuscripts. The are divided into ten sections: motivation scope, data sources, choice of genetic variants, variant harmonization, primary analysis, supplementary sensitivity (one section on robust statistical methods one other approaches), extensions additional analyses,...
Statin treatment and variants in the gene encoding HMG-CoA reductase are associated with reductions both concentration of LDL cholesterol risk coronary heart disease, but also modest hyperglycaemia, increased bodyweight, modestly type 2 diabetes, which no way offsets their substantial benefits. We sought to investigate associations cholesterol-lowering PCSK9 diabetes related biomarkers gauge likely effects inhibitors on risk.In this mendelian randomisation study, we used data from cohort...
Abstract Estimates from Mendelian randomization studies of unrelated individuals can be biased due to uncontrolled confounding familial effects. Here we describe methods for within-family analyses and use simulation show that family-based reduce such biases. We illustrate empirically how effects affect estimates using data 61,008 siblings the Nord-Trøndelag Health Study UK Biobank replicated our findings 222,368 23andMe. Both within family reproduced established lower BMI reducing risk...
Positive associations between inflammatory biomarkers and risk of psychiatric disorders, including schizophrenia, have been reported in observational studies. However, conventional studies are prone to bias, such as reverse causation residual confounding, thus limiting our understanding the effect (if any) on schizophrenia risk.To evaluate whether an developing schizophrenia.Two-sample mendelian randomization study using genetic variants associated with instrumental variables improve...
<b>Objective</b> To determine whether educational attainment is a causal risk factor in the development of coronary heart disease. <b>Design</b> Mendelian randomisation study, using genetic data as proxies for education to minimise confounding. <b>Setting</b> The main analysis used from two large consortia (CARDIoGRAMplusC4D and SSGAC), comprising 112 studies predominantly high income countries. Findings mendelian analyses were then compared against results traditional...
Population-based data on COVID-19 are urgently needed. We report three rounds of probability sample household surveys in the state Rio Grande do Sul (Brazil), carried out nine large municipalities using Wondfo lateral flow point-of-care test for immunoglobulin M and G antibodies against SARS-CoV-2 (https://en.wondfo.com.cn/product/wondfo-sars-cov-2-antibody-test-lateral-flow-method-2/). Before survey use, assay underwent four validation studies with pooled estimates sensitivity (84.8%; 95%...
Mitochondria (MT), the major site of cellular energy production, are under dual genetic control by 37 mitochondrial DNA (mtDNA) genes and numerous nuclear (MT-nDNA). In CHARGEmtDNA+ Consortium, we studied associations mtDNA MT-nDNA with body mass index (BMI), waist-hip-ratio (WHR), glucose, insulin, HOMA-B, HOMA-IR, HbA1c. This 45-cohort collaboration comprised 70,775 (insulin) to 170,202 (BMI) pan-ancestry individuals. Validation imputation variants was followed single-variant gene-based...
Abstract Mendelian randomization (MR) has been increasingly used to strengthen causal inference in observational epidemiology. Methodological developments the field allow detecting and/or adjusting for different potential sources of bias, mainly bias due horizontal pleiotropy (or “off‐target” genetic effects). Another source is nonrandom matching between spouses (i.e., assortative mating). In this study, we performed simulations investigate caused MR by mating. We found that can arise either...
Two-sample Mendelian randomization (MR) allows the use of freely accessible summary association results from genome-wide studies (GWAS) to estimate causal effects modifiable exposures on outcomes. Some GWAS adjust for heritable covariables in an attempt direct genetic variants trait interest. One, both or neither exposure and outcome may have been adjusted covariables.We performed a simulation study comprising different scenarios that could motivate covariable adjustment analysed real data...