A5041708405- Genetic Associations and Epidemiology
- Genetics and Neurodevelopmental Disorders
- Bioinformatics and Genomic Networks
- Genetic Mapping and Diversity in Plants and Animals
- Epigenetics and DNA Methylation
- Cannabis and Cannabinoid Research
- Alzheimer's disease research and treatments
- Nutrition, Genetics, and Disease
- Genomics and Chromatin Dynamics
- Health, Environment, Cognitive Aging
- Advanced Proteomics Techniques and Applications
- Genomic variations and chromosomal abnormalities
- Sleep and related disorders
- Genetic and phenotypic traits in livestock
- Gene expression and cancer classification
- Bipolar Disorder and Treatment
- Alcohol Consumption and Health Effects
- Attention Deficit Hyperactivity Disorder
- Genomics and Rare Diseases
- Cognitive Abilities and Testing
- Child Nutrition and Feeding Issues
- Dementia and Cognitive Impairment Research
- Bayesian Modeling and Causal Inference
- Humor Studies and Applications
- Celiac Disease Research and Management
Amsterdam Neuroscience
2015-2021
National Nuclear Security Administration
2021
National Academies of Sciences, Engineering, and Medicine
2021
Amsterdam UMC Location Vrije Universiteit Amsterdam
2018-2020
Vrije Universiteit Amsterdam
2015-2019
University of Amsterdam
2011-2015
University Medical Center Utrecht
2013-2015
Amsterdam UMC Location University of Amsterdam
2013-2015
University Medical Center
2015
Allen Institute for Brain Science
2014
Abstract Objectives Genome‐wide association studies (GWAS) have become increasingly popular to identify associations between single nucleotide polymorphisms (SNPs) and phenotypic traits. The GWAS method is commonly applied within the social sciences. However, statistical analyses will need be carefully conducted use of dedicated genetics software required. This tutorial aims provide a guideline for conducting genetic analyses. Methods We discuss explain key concepts illustrate how conduct...
Genome-wide association studies (GWAS) of psychological traits are generally conducted on (dichotomized) sums items or symptoms (e.g., case-control status), and not the individual themselves. We conduct large-scale GWAS 12 neuroticism observe notable replicable variation in genetic signal between items. Within samples, correlations among range 0.38 0.91 (mean r
According to the World Health Organization, about 2 billion people drink alcohol. Excessive alcohol consumption can result in addiction, which is one of most prevalent neuropsychiatric diseases afflicting our society today. Prevention and intervention binging adolescents treatment alcoholism are major unmet challenges affecting health-care system alike. Our newly formed German SysMedAlcoholism consortium using a new systems medicine approach intends (1) define individual neurobehavioral risk...
Gene-set analysis provides insight into which functional and biological properties of genes are aetiologically relevant for a particular phenotype. But have multiple properties, these often correlated across genes. This can cause confounding in gene-set analysis, because one property may be statistically associated even if biologically irrelevant to the phenotype, by being with gene that relevant. To address this issue we present novel conditional interaction approach, attains considerable...
The MIR137 locus is a replicated genetic risk factor for schizophrenia. risk-associated allele reported to increase miR-137 expression and overexpression alters synaptic transmission in mouse hippocampus. We investigated the cellular mechanisms underlying these observed effects hippocampal neurons culture. First, we correlated of genes human postmortem brain. Some evidence increased MIR137HG was observed, especially hippocampus disease-associated genotype. Second, neurons, confirmed...
Neuroticism is an important risk factor for psychiatric traits including depression 1 , anxiety 2,3 and schizophrenia 4–6 . Previous genome-wide association studies 7–12 (GWAS) reported 16 genomic loci 10–12 Here we report the largest neuroticism GWAS meta-analysis to date (N=449,484), identify 136 independent significant (124 novel), implicating 599 genes. Extensive functional follow-up analyses show enrichment in several brain regions involvement of specific cell-types, dopaminergic...
ABSTRACT After a decade of genome-wide association studies (GWASs), fundamental questions in human genetics are still unanswered, such as the extent pleiotropy across genome, nature trait-associated genetic variants and disparate architecture traits. The current availability hundreds GWAS results provide unique opportunity to gain insight into these questions. In this study, we harmonized systematically analysed 4,155 publicly available GWASs. For subset well-powered on 558 traits, an...
Complex diseases are often highly heritable. However, for many complex traits only a small proportion of the heritability can be explained by observed genetic variants in traditional genome-wide association (GWA) studies. Moreover, some those few significant SNPs have been identified. Single SNP methods test at single SNP, ignoring effect other SNPs. We show using simple multi-locus odds model disease that moderate to large sizes causal may estimated as relatively testing. This...
Induced pluripotent stem cell (iPSC) technology is more and used for the study of genetically complex human disease but challenged by variability, sample size polygenicity. We discuss studies involving iPSC-derived neurons from patients with Schizophrenia (SCZ), to exemplify that heterogeneity in sampling strategy complicate detection mechanisms. offer a solution controlling variability within between iPSC using specific patient selection strategies.
Abstract Late onset Alzheimer’s disease (AD) is the most common form of dementia with more than 35 million people affected worldwide, and no curative treatment available. AD highly heritable recent genome-wide meta-analyses have identified over 20 genomic loci associated AD, yet only explaining a small proportion genetic variance indicating that undiscovered exist. Here, we performed largest association study clinically diagnosed AD-by-proxy (71,880 cases, 383,378 controls). status based on...
Abstract Insomnia is the second-most prevalent mental disorder, with no sufficient treatment available. Despite a substantial role of genetic factors, only handful genes have been implicated and insight into associated neurobiological pathways remains limited. Here, we use an unprecedented large association sample (N=1,331,010) to allow detection number variants gain biological functions, cell types tissues involved in insomnia complaints. We identify 202 genome-wide significant loci...