Felix R. Day
- Genetic Associations and Epidemiology
- Birth, Development, and Health
- Epigenetics and DNA Methylation
- Ovarian function and disorders
- Genetic and phenotypic traits in livestock
- Nutrition, Genetics, and Disease
- Growth Hormone and Insulin-like Growth Factors
- Hypothalamic control of reproductive hormones
- Adipose Tissue and Metabolism
- Reproductive Biology and Fertility
- Genetic Mapping and Diversity in Plants and Animals
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- RNA Research and Splicing
- Obesity, Physical Activity, Diet
- RNA modifications and cancer
- Genetic Syndromes and Imprinting
- Ovarian cancer diagnosis and treatment
- Genetics, Aging, and Longevity in Model Organisms
- BRCA gene mutations in cancer
- Regulation of Appetite and Obesity
- Health, Environment, Cognitive Aging
- Sexual Differentiation and Disorders
- Genomics and Chromatin Dynamics
- Lipid metabolism and disorders
- Genetics and Physical Performance
MRC Epidemiology Unit
2016-2025
University of Cambridge
2016-2025
Wellcome/MRC Institute of Metabolic Science
2020-2025
Medical Research Council
2013-2024
Phillips Exeter Academy
2024
Engineering Service Center und Handel (Germany)
2024
Wellcome Trust
2019-2023
Cambridge School
2015-2021
National Nuclear Security Administration
2021
National Academies of Sciences, Engineering, and Medicine
2021
Abstract Early puberty timing is associated with higher risks for type 2 diabetes (T2D) and cardiovascular disease in women therefore represents a potential target early preventive interventions. We characterised the range of diseases other adverse health outcomes or late men very large UK Biobank study. Recalled past/current were self-reported by questionnaire. limited analyses to individuals White ethnicity (250,037 women; 197,714 men) at least 500 cases (~0·2% prevalence) we applied...
Given the anthropometric differences between men and women previous evidence of sex-difference in genetic effects, we conducted a genome-wide search for sexually dimorphic associations with height, weight, body mass index, waist circumference, hip waist-to-hip-ratio (133,723 individuals) took forward 348 SNPs into follow-up (additional 137,052 total 94 studies. Seven loci displayed significant (FDR<5%), including four previously established (near GRB14/COBLL1, LYPLAL1/SLC30A10, VEGFA,...
Abstract Polycystic ovary syndrome (PCOS) is the most common reproductive disorder in women, yet there little consensus regarding its aetiology. Here we perform a genome-wide association study of PCOS up to 5,184 self-reported cases White European ancestry and 82,759 controls, with follow-up further ∼2,000 clinically validated ∼100,000 controls. We identify six signals for at statistical significance ( P <5 × 10 −8 ), in/near genes ERBB4/HER4 , YAP1 THADA FSHB RAD50 KRR1. Variants three...