Cheng‐Jian Xu
A5054973403- Epigenetics and DNA Methylation
- Metabolomics and Mass Spectrometry Studies
- Asthma and respiratory diseases
- Birth, Development, and Health
- Immune responses and vaccinations
- Spectroscopy and Chemometric Analyses
- Neonatal Respiratory Health Research
- Childhood Cancer Survivors' Quality of Life
- Diabetes and associated disorders
- IL-33, ST2, and ILC Pathways
- Analytical Chemistry and Chromatography
- Pediatric health and respiratory diseases
- COVID-19 Clinical Research Studies
- Genetic Associations and Epidemiology
- Liver Disease Diagnosis and Treatment
- Air Quality and Health Impacts
- Immune cells in cancer
- SARS-CoV-2 and COVID-19 Research
- Traditional Chinese Medicine Analysis
- Single-cell and spatial transcriptomics
- Respiratory viral infections research
- T-cell and B-cell Immunology
- Fault Detection and Control Systems
- Gene expression and cancer classification
- Immune Cell Function and Interaction
Centre for Individualised Infection Medicine
2019-2025
Helmholtz Centre for Infection Research
2019-2025
Center for Experimental and Clinical Infection Research
2019-2025
Medizinische Hochschule Hannover
2019-2025
Riverside Hospital of Guangxi Zhuang Autonomous Region
2025
Radboud University Nijmegen
2020-2024
Radboud University Medical Center
2020-2024
University of Electronic Science and Technology of China
2024
Taylor's University
2024
Sichuan Tourism University
2022-2024
Epidemiological studies suggest that a father's diet can influence offspring health. A proposed mechanism for paternal transmission of environmental information is via the sperm epigenome. The epigenome includes heritable such as DNA methylation. We hypothesize dietary supply methyl donors will alter epigenetic reprogramming in sperm. Here we feed male mice either folate-deficient or folate-sufficient throughout life. Paternal folate deficiency associated with increased birth defects...
Non-specific protective effects of certain vaccines have been reported, and long-term boosting innate immunity, termed trained has proposed as one the mechanisms mediating these effects. Several epidemiological studies suggested cross-protection between influenza vaccination COVID-19. In a large academic Dutch hospital, we found that SARS-CoV-2 infection was less common among employees who had received previous vaccination: relative risk reductions 37% 49% were observed following during...
Immune responses are tightly regulated yet highly variable between individuals. To investigate human population variation of trained immunity, we immunized healthy individuals with Bacillus Calmette-Guérin (BCG). This live-attenuated vaccine induces not only an adaptive immune response against tuberculosis but also triggers innate activation and memory that indicative immunity. We established personal profiles chromatin accessibility maps over a 90-day time course BCG vaccination in 323 Our...
Aging affects human immune system functionality, increasing susceptibility to immune-mediated diseases. While gene expression programs accurately reflect function, their relationship with biological aging and health status remains unclear. Here we developed robust, cell-type-specific clocks (sc-ImmuAging) for the myeloid lymphoid cell populations in circulation within peripheral blood mononuclear cells, using single-cell RNA-sequencing data from 1,081 healthy individuals aged 18 97 years....
Abstract High deviations resulting from prediction model, gender and population difference have limited age estimation application of DNA methylation markers. Here we identified 2,957 novel age-associated sites ( P < 0.01 R 2 > 0.5) in blood eight pairs Chinese Han female monozygotic twins. Among them, nine (false discovery rate 0.01), along with three other reported sites, were further validated 49 unrelated volunteers ages 20–80 years by Sequenom Massarray. A total 95 CpGs covered...
The evidence supporting an association between traffic-related air pollution exposure and incident childhood asthma is inconsistent may depend on genetic factors.To identify gene-environment interaction effects using genome-wide single-nucleotide polymorphism (SNP) data exposure. Identified loci were further analyzed at epigenetic transcriptomic levels.We used land use regression models to estimate individual (represented by outdoor NO2 levels) the birth address performed a study for...
Ambient air pollution is associated with numerous adverse health outcomes, but the underlying mechanisms are not well understood; epigenetic effects including altered DNA methylation could play a role. To evaluate associations of long-term exposure in blood, we conducted an epigenome-wide association study Korean chronic obstructive pulmonary disease cohort (N = 100 60 cases) using Illumina's Infinium HumanMethylation450K Beadchip. Annual average concentrations particulate matter ≤ 10 μm...
Allergic diseases often occur in combination (multimorbidity). Human blood transcriptome studies have not addressed multimorbidity. Large-scale gene expression data were combined to retrieve biomarkers and signaling pathways disentangle allergic multimorbidity phenotypes.Integrated transcriptomic analysis was conducted 1233 participants with a discovery phase using (Human Transcriptome Array 2.0) from whole of 786 children three European birth cohorts (MeDALL), replication RNA Sequencing an...
Cigarette smoking influences DNA methylation genome wide, in newborns from pregnancy exposure and adults personal smoking. Whether a unique signature exists for
Trained immunity refers to the long-lasting memory traits of innate immunity. Recent studies have shown that trained is orchestrated by sustained changes in epigenetic marks and metabolic pathways, leading an altered transcriptional response a second challenge. However, potential heterogeneity trained-immunity induction immune cells has not been explored. In this study, we demonstrate cellular programs 4 different inducers monocyte populations at single-cell resolution. Specifically,...
Understanding the complex orchestrated inflammation in atopic dermatitis (AD), one of most common chronic inflammatory diseases worldwide, is essential for therapeutic approaches. However, a comparative analysis on single-cell level signatures correlated with severity missing so far.We applied RNA and T-cell receptor (TCR) sequencing immune cells enriched from skin biopsies matched blood samples AD comparison psoriasis (PS) patients.Clonally propagated skin-derived T showed disease-specific...