Stella Aslibekyan
A5083631214- Epigenetics and DNA Methylation
- Genetic Associations and Epidemiology
- Birth, Development, and Health
- RNA modifications and cancer
- Diet and metabolism studies
- Metabolomics and Mass Spectrometry Studies
- Nutrition, Genetics, and Disease
- Obesity, Physical Activity, Diet
- Cholesterol and Lipid Metabolism
- Cancer-related gene regulation
- Liver Disease Diagnosis and Treatment
- Nutritional Studies and Diet
- Adipose Tissue and Metabolism
- Health, Environment, Cognitive Aging
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Lipid metabolism and disorders
- Fatty Acid Research and Health
- Cancer-related molecular mechanisms research
- Parkinson's Disease Mechanisms and Treatments
- Diet, Metabolism, and Disease
- Peroxisome Proliferator-Activated Receptors
- Mitochondrial Function and Pathology
- Bioinformatics and Genomic Networks
- Lipid metabolism and biosynthesis
- Genetics and Neurodevelopmental Disorders
23andMe (United States)
2019-2024
University of Alabama at Birmingham
2013-2022
University of Kentucky
2014-2021
Mountain View College
2019
University of Alabama
2013-2016
University of Minnesota
2016
Tufts University
2014-2016
Instituto de Salud Carlos III
2014
Bellvitge University Hospital
2014
Institut d'Investigació Biomédica de Bellvitge
2014
Obesity is an important component of the pathophysiology chronic diseases. Identifying epigenetic modifications associated with elevated adiposity, including DNA methylation variation, may point to genomic pathways that are dysregulated in numerous conditions. The Illumina 450K Bead Chip array was used assay leukocyte obtained from 2097 African American adults Atherosclerosis Risk Communities (ARIC) study. Mixed-effects regression models were test association beta value concurrent body mass...
Background— Genetic research regarding blood lipids has largely focused on DNA sequence variation; few studies have explored epigenetic effects. Genome-wide surveys of methylation may uncover factors influencing lipid metabolism. Methods and Results— To identify whether differential cytosine-(phosphate)-guanine dinucleotides (CpGs) correlated with phenotypes, we isolated from CD4+ T cells quantified the proportion sample at >450 000 CpGs by using Illumina Infinium HumanMethylation450...
Abstract Irritable bowel syndrome (IBS) results from disordered brain–gut interactions. Identifying susceptibility genes could highlight the underlying pathophysiological mechanisms. We designed a digestive health questionnaire for UK Biobank and combined identified cases with IBS independent cohorts. conducted genome-wide association study 53,400 433,201 controls replicated significant associations in 23andMe panel (205,252 1,384,055 controls). Our confirmed six genetic loci IBS. Implicated...
Objective To conduct an epigenome-wide analysis of DNA methylation and obesity traits. Methods was quantified in CD4+ T-cells using the Illumina Infinium HumanMethylation450 array 991 participants Genetics Lipid Lowering Drugs Diet Network. Methylation at individual cytosine-phosphate-guanine (CpG) sites as a function body mass index (BMI) waist circumference (WC), adjusting for age, gender, study site, T-cell purity, smoking, family structure, modeled. Results Epigenome-wide significant...
DNA methylation is an important molecular-level phenotype that links genotypes and complex disease traits. Previous studies have found local correlation between genetic variants levels (cis-meQTLs). However, general mechanisms underlying cis-meQTLs are unclear. We conducted a cis-meQTL analysis of the Genetics Lipid Lowering Drugs Diet Network data (n = 593). over 80% at CpG sites (meSNPs) meQTL loci (P-value<10(-9)), meSNPs account for two thirds strongest signals (P-value<10(-200)). Beyond...
Cigarette smoking influences DNA methylation genome wide, in newborns from pregnancy exposure and adults personal smoking. Whether a unique signature exists for
Genotype-phenotype association studies often combine phenotype data from multiple to increase statistical power. Harmonization of the usually requires substantial effort due heterogeneity in definitions, study design, collection procedures, and data-set organization. Here we describe a centralized system for harmonization that includes input domain experts, quality control, documentation, reproducible results, data-sharing mechanisms. This was developed National Heart, Lung, Blood...
Recently, epigenetic age acceleration-or older in comparison to chronological age-has been robustly associated with mortality and various morbidities. However, accelerated aging has not widely investigated relation inflammatory or metabolic markers, including postprandial lipids.We estimated measures of acceleration 830 Caucasian participants from the Genetics Of Lipid Lowering Drugs diet Network (GOLDN) considering two calculations based on differing sets 5'-Cytosine-phosphate-guanine-3'...
Lipoprotein subfractions help discriminate cardiometabolic disease risk. Genetic loci validated as associating with lipoprotein measures do not account for a large proportion of the individual variation in measures. We hypothesized that DNA methylation levels across genome contribute to interindividual Using data from participants Genetics Lipid Lowering Drugs and Diet Network (n = 663 discovery n 331 replication stages, respectively), we conducted first systematic screen determine...
In this study, we conducted an epigenome-wide association study of metabolic syndrome (MetS) among 846 participants European descent in the Genetics Lipid Lowering Drugs and Diet Network (GOLDN). DNA was isolated from CD4+ T cells methylation at ~470,000 cytosine-phosphate-guanine dinucleotide (CpG) pairs assayed using Illumina Infinium HumanMethylation450 BeadChip. We modeled percentage individual CpGs as a function MetS linear mixed models. A Bonferroni-corrected P-value 1.1 x 10−7...
Abstract COVID-19 presents with a wide range of severity, from asymptomatic in some individuals to fatal others. Based on study over one million 23andMe research participants, we report genetic and non-genetic associations testing positive for COVID-19, respiratory symptoms, hospitalization. Risk factors hospitalization include advancing age, male sex, elevated body mass index, lower socio-economic status, non-European ancestry, pre-existing cardio-metabolic conditions. Using trans-ethnic...
Objective Despite the evidence in support of anti-inflammatory and triglyceride-lowering effects fenofibrate, little is known about genetic determinants observed heterogeneity treatment response. This study provides first genome-wide examination fenofibrate on systemic inflammation. Methods Biomarkers inflammation were measured participants Genetics Lipid Lowering Drugs Diet Network (n=1092) before after a 3-week daily with 160 mg fenofibrate. Two inflammatory patterns [high-sensitivity...
The high prevalence of obesity among US adults has resulted in significant increases associated metabolic disorders such as diabetes, dyslipidemia, and blood pressure. Together, these constitute syndrome, a clinically defined condition highly prevalent African-Americans. Identifying epigenetic alterations with syndrome may provide additional information regarding etiology beyond current evidence from genome-wide association studies. Data on DNA methylation was assessed 614 African-Americans...
Postprandial lipemia (PPL), the increased plasma TG concentration after consuming a high-fat meal, is an independent risk factor for CVD. Individual responses to meal high in fat vary greatly, depending on genetic and lifestyle factors. However, only few loci have been associated with TG-PPL response. Heritable epigenomic changes may be significant contributors unexplained inter-individual PPL variability. We conducted epigenome-wide association study 979 subjects DNA methylation measured...
Parkinson's disease (PD) is a neurodegenerative disorder with complex etiology. Multiple genetic and environmental factors have been associated PD, but most PD risk remains unexplained. The aim of this study was to test for statistical interactions between PD-related exposures in the 23andMe, Inc. research dataset.