A5000604836- Regulation of Appetite and Obesity
- Gastrointestinal motility and disorders
- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Biochemical Analysis and Sensing Techniques
- Neuropeptides and Animal Physiology
- Gastroesophageal reflux and treatments
- Stress Responses and Cortisol
- Congenital gastrointestinal and neural anomalies
- Adipokines, Inflammation, and Metabolic Diseases
- Neuroendocrine regulation and behavior
- Infant Health and Development
- Digestive system and related health
- Eating Disorders and Behaviors
- Diet, Metabolism, and Disease
- Eosinophilic Esophagitis
- Child Nutrition and Feeding Issues
- Helicobacter pylori-related gastroenterology studies
- Peptidase Inhibition and Analysis
- Hypothalamic control of reproductive hormones
- Medical and Health Sciences Research
- Mast cells and histamine
- Health, psychology, and well-being
- Long-Term Effects of COVID-19
- Pancreatic function and diabetes
Krankenhaus vom Roten Kreuz
2018-2023
Helios Kliniken
2017-2022
Humboldt-Universität zu Berlin
2017-2022
Charité - Universitätsmedizin Berlin
2012-2022
Freie Universität Berlin
2017-2022
Deutsche Schmerzgesellschaft
2022
Israelitisches Krankenhaus
2022
Universitätsklinikum Tübingen
2021-2022
Martin-Luther-Krankenhaus
2011-2021
University of California, Los Angeles
2011-2017
Abstract Irritable bowel syndrome (IBS) results from disordered brain–gut interactions. Identifying susceptibility genes could highlight the underlying pathophysiological mechanisms. We designed a digestive health questionnaire for UK Biobank and combined identified cases with IBS independent cohorts. conducted genome-wide association study 53,400 433,201 controls replicated significant associations in 23andMe panel (205,252 1,384,055 controls). Our confirmed six genetic loci IBS. Implicated...
Kisspeptin is distributed not only in brain areas for regulating reproduction but also nuclei involved feeding control. Whether kisspeptin alters food intake unknown mice. We examined how kisspeptin-10 influences after intracerebroventricular injection mice using automated monitoring. Kisspeptin-10 (0.3, 1, and 3 μg/mouse) dose-dependently inhibited the response to an overnight fast by 50, 95, 90% respectively, during 2-3 h period postinjection. The 1μg/mouse dose reduced 4-h cumulative 28%...
Bile acids may be involved in the regulation of food intake and energy metabolism. The aim study was to investigate association plasma bile with body mass index (BMI) possible involvement circulating modulation physical activity eating behavior. Blood obtained a group hospitalized patients normal weight (BMI 18.5-25 kg/m(2)), underweight (anorexia nervosa, BMI < 17.5 kg/m(2)) overweight (obesity 30-40, 40-50 >50 kg/m(2), n = 14-15/group) acid concentrations assessed. Physical were measured...
Abkürzungsverzeichnis ACPO: akute colonische Pseudoobstruktion, syn. Ogilvie-Syndrom CED: chronisch entzündliche Darmerkrankungen CI: Confidence Interval, engl. CIPO: chronische intestinale Pseudoobstruktion CMV: Cytomegalie-Virus ENS: enterisches Nervensystem FBDSI: Functional Bowel Disorder Severity Index FBS: Funktionelle Bauchschmerzen (engl. FAB, functional abdominal pain) FD: Dyspepsie GSRS-IBS: Gastrointestinal Symptom Rating Score HADS: Hospital Anxiety Depression Scale, H&E:...
Abkürzungsverzeichnis AST: Aspartat-Aminotransferase ALT: Alanin-Aminotransferase BFI: bowel function index CACP: Chirurgische Arbeitsgemeinschaft für Coloproktologie CAS: constipation assessment Skala (scale) CSBM: komplette spontane Stuhlentleerung (complete spontaneous movement) DEGAM: Deutsche Gesellschaft Allgemeinmedizin und Familienmedizin DGAV: Allgemein- Viszeralchirugie DGEM: Ernährungsmedizin DGG: Geriatrie DGIM: Innere Medizin DGK: Koloproktologie DGNHK: Naturheilkunde DGNM:...
Carbohydrate malabsorption is frequent in patients with functional gastrointestinal disorders and healthy volunteers can cause symptoms mimicking irritable bowel syndrome (IBS). The aim of this study was to investigate the prevalence symptomatic lactose fructose a large population IBS-like based on Rome II criteria.Patients unclear abdominal discomfort (n = 2,390) underwent (50 g) hydrogen (H2) breath tests depending results further testing 25 g or 50 glucose, upper endoscopy duodenal...
Anorexia nervosa (AN) is accompanied by severe somatic and psychosocial complications. However, the underlying pathogenesis poorly understood, treatment challenging often hampered high relapse. Therefore, more basic research needed to better understand disease. Since hyperactivity plays a role in AN, we characterized an animal model mimic AN using restricted feeding hyperactivity. Female Sprague-Dawley rats were divided into four groups: no activity/ad libitum (ad libitum, AL, n = 9),...
Neurogastroenterological disorders (NGDs) are highly prevalent and substantially impact patients' quality of life. Effective treatment NGDs depends on the competence training medical caregivers. Students' perceived in neurogastroenterology its place school curricula assessed this study.A multi-center digital survey among students was conducted at five universities. Self-ratings regarding basic mechanisms, diagnosis, six chronic conditions were assessed. These included irritable bowel...
Clinical studies are evaluating the efficacy of synthetic ghrelin agonists in postoperative ileus management. However, control secretion under conditions gastric is largely unknown. Peripheral somatostatin inhibits animals and humans. We investigated time course changes postsurgery fasted rats whether receptor subtype 2 (sst(2)) signaling involved. Abdominal surgery (laparotomy 1-min cecal palpation) induced a rapid long-lasting decrease plasma acyl levels as shown by 64, 67, 59% reduction...
Background Activation of brain somatostatin receptors (sst1–5) with the stable pan-sst1–5 agonist, ODT8-SST blocks acute stress and central corticotropin-releasing factor (CRF)-mediated activation endocrine adrenal sympathetic responses. Brain CRF signaling is involved in delaying gastric emptying (GE) immediately post surgery. We investigated whether sst pathways modulates surgical stress-induced inhibition food intake. Methods Fasted rats were injected intracisternally (i.c.) agonists...