A5010241733- Gastrointestinal motility and disorders
- Neuropeptides and Animal Physiology
- Stress Responses and Cortisol
- Regulation of Appetite and Obesity
- Diet and metabolism studies
- Biochemical Analysis and Sensing Techniques
- Neuroendocrine regulation and behavior
- Receptor Mechanisms and Signaling
- Hormonal Regulation and Hypertension
- Adipose Tissue and Metabolism
- Helicobacter pylori-related gastroenterology studies
- Neuroscience of respiration and sleep
- Gastroesophageal reflux and treatments
- Adrenal Hormones and Disorders
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Infant Health and Development
- Neuroendocrine Tumor Research Advances
- Vagus Nerve Stimulation Research
- Biochemical effects in animals
- Enhanced Recovery After Surgery
- Pain Mechanisms and Treatments
- Hypothalamic control of reproductive hormones
- Clinical Nutrition and Gastroenterology
- Electrolyte and hormonal disorders
- Cancer, Stress, Anesthesia, and Immune Response
University of California, Los Angeles
2015-2024
VA Greater Los Angeles Healthcare System
2015-2024
VA West Los Angeles Medical Center
2009-2023
UCLA Health
2010-2023
University of California System
1987-2020
Center for Digestive and Liver Diseases
1994-2018
Wroclaw Medical University
2014
Brentwood Biomedical Research Institute
2012
University of Washington
2012
West Los Angeles College
1991-2011
Leptin is a circulating protein involved in the long-term regulation of food intake and body weight. Cholecystokinin (CCK) released postprandially elicits satiety signals. We investigated interaction between leptin CCK-8 short-term induced by 24-hr fasting lean mice. Leptin, injected intraperitoneally (i.p.) at low doses (4–120 μg/kg), which did not influence feeding behavior for first 3 hr postinjection, decreased dose dependently 47–83% during hour when coinjected with subthreshold CCK....
The immediate and long-term effects of exposure to early life stress (ELS) have been documented in humans animal models. Even relatively brief periods during the first 10 days rodents can impact later behavioral regulation vulnerability develop adult pathologies, particular an impairment cognitive functions neurogenesis, but also modified social, emotional, conditioned fear responses. development preclinical models ELS allows examination mechanisms testing therapeutic approaches that are not...
Hypothalamic nesfatin-1, derived from the nucleobindin2 (NUCB2) precursor, inhibits nocturnal food intake and body weight gain in rats. Nesfatin-1 is able to cross blood-brain barrier, suggesting a peripheral source of nesfatin-1. Many centrally acting regulatory neuropeptides are also produced periphery, especially gastrointestinal tract. Therefore, we investigated gene expression NUCB2 distribution nesfatin-1-immunoreactive cells stomach. Microarray mRNA profiles purified small endocrine...
Hans Selye's single author short letter to Nature (1936, 138(3479):32) inspired a huge and still growing wave of medical research. His experiments with rats led recognition the "general adaptation syndrome", later renamed by Selye "stress response": triad enlarged adrenal glands, lymph node thymic atrophy, gastric erosions/ulcers. Because major role glucocorticoids (named Selye), he performed extensive structure-activity studies in 1930s-1940s, resulting first rational classification steroid...
Nesfatin-1, derived from nucleobindin2, is expressed in the hypothalamus and reported one study to reduce food intake (FI) rats. To characterize central anorexigenic action of nesfatin-1 whether gastric emptying (GE) altered, we injected into lateral brain ventricle (intracerebroventricular, icv) or fourth (4v) chronically cannulated rats cisterna magna (intracisternal, ic) under short anesthesia compared with ip injection. Nesfatin-1 (0.05 μg/rat, decreased 2–3 h 3–6 dark-phase FI by 87...
Bombesin acts within the brain to produce a prompt and sustained hyperglycemia, hyperglucagonemia, relative or absolute hypoinsulinemia. does not decrease plasma glucose turnover. Acute adrenalectomy but hypophysectomy prevents hyperglycemia hyperglucagonemia after intracisternal administration of bombesin. Administration bombesin into lateral ventricle awake, unrestrained animals results in elevation glucose, preceded by significant increase epinephrine no norepinephrine dopamine. Systemic...
Intracisternal injection of ovine corticotropin-releasing factor (CRF) into the pylorus-ligated rat or with gastric fistula resulted in a dose-dependent inhibition secretion stimulated pentagastrin thyrotropin-releasing hormone. When injected lateral hypothalamus--but not when cerebral cortex—CRF suppressed pentagastrin-stimulated acid secretion. The inhibitory effect CRF was blocked by vagotomy and adrenalectomy but hypophysectomy naloxone treatment. These results indicate that acts within...
Recently characterized selective agonists and developed antagonists for the corticotropin releasing factor (CRF) receptors are new tools to investigate stress-related functional changes. The influence of mammalian CRF related peptides injected intracerebroventricularly (i.c.v.) on gastric colonic motility, receptor subtypes involved their role in response stress were studied conscious mice. CRF(1)/CRF(2) rat urocortin 1 (rUcn 1) rat/human (r/h CRF), preferential CRF(1) agonist ovine (oCRF),...
The present study evaluates the central nervous system action of rat corticotropin-releasing factor (CRF) on gastric emptying a liquid meal in conscious rats using phenol red method. Intracisternal injection CRF (63-210 pmol) dose-dependently inhibited by 37-80%. Peptide was rapid onset, long acting, and not mimicked intracisternal growth hormone-releasing factor. CRF-induced inhibition reversed subdiaphragmatic vagotomy but naloxone pretreatment or adrenalectomy. Intravenous (21-630 also...
Several neuropeptides injected intracisternally were assessed for their effects on gastric secretion in rats. Bombesin (1 microgram) completely suppressed acid secretion, produced the volume of and partially blocked insulin- or 2-deoxy-D-glucose-induced stimulation output. The inhibitory effect this peptide is dose-dependent, long-acting, reversible, specific. response appears to be central nervous system-mediated; its expression not dependent vagus nerve adrenal glands, does rely a decrease...