Tenghao Zheng
A5049149319- Gastrointestinal motility and disorders
- Diet and metabolism studies
- Gut microbiota and health
- Helicobacter pylori-related gastroenterology studies
- Digestive system and related health
- Nutritional Studies and Diet
- Congenital gastrointestinal and neural anomalies
- COVID-19 Clinical Research Studies
- Liver Disease Diagnosis and Treatment
- Dietary Effects on Health
- SARS-CoV-2 and COVID-19 Research
- Anorectal Disease Treatments and Outcomes
- Pelvic floor disorders treatments
- Ion channel regulation and function
- Clostridium difficile and Clostridium perfringens research
- RNA modifications and cancer
- Microscopic Colitis
- Celiac Disease Research and Management
- Ion Channels and Receptors
- Gastroesophageal reflux and treatments
- Infant Health and Development
- Blood groups and transfusion
- Tryptophan and brain disorders
- Barrier Structure and Function Studies
- Ion Transport and Channel Regulation
Monash University
2020-2025
Karolinska Institutet
2016-2023
Norwegian Institute of Public Health
2021
Biogipuzkoa Health Research Institute
2020
Zhengzhou University
2010-2014
Henan Provincial People's Hospital
2014
There is considerable variation in disease behavior among patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes 2019 (Covid-19). Genomewide association analysis may allow for identification of potential genetic factors involved development Covid-19.
Abstract Irritable bowel syndrome (IBS) results from disordered brain–gut interactions. Identifying susceptibility genes could highlight the underlying pathophysiological mechanisms. We designed a digestive health questionnaire for UK Biobank and combined identified cases with IBS independent cohorts. conducted genome-wide association study 53,400 433,201 controls replicated significant associations in 23andMe panel (205,252 1,384,055 controls). Our confirmed six genetic loci IBS. Implicated...
BACKGROUND: Fermentation of dietary fiber by the gut microbiota leads to production metabolites called short-chain fatty acids, which lower blood pressure and exert cardioprotective effects. Short-chain acids activate host signaling responses via functionally redundant receptors GPR41 GPR43, are highly expressed immune cells. Whether how these protect against hypertension or mediate effects remains unknown. METHODS: Cardiovascular phenotype was assessed in untreated Ang II (angiotensin II)...
IBS is a common gut disorder of uncertain pathogenesis. Among other factors, genetics and certain foods are proposed to contribute. Congenital sucrase-isomaltase deficiency (CSID) rare genetic form disaccharide malabsorption characterised by diarrhoea, abdominal pain bloating, which features IBS. We tested (SI) gene variants for their potential relevance in IBS.We sequenced SI exons seven familial cases, screened four CSID mutations (p.Val557Gly, p.Gly1073Asp, p.Arg1124Ter p.Phe1745Cys)...
Abstract Aims Animal models are regularly used to test the role of gut microbiome in hypertension. Small-scale pre-clinical studies have investigated changes angiotensin II hypertensive model. However, is influenced by internal and external experimental factors, which not considered study design. Once these factors accounted for, it unclear if signatures reproduceable. We aimed determine influence treatment on using a large diverse cohort mice quantify magnitude other contribute variations....
Patients with irritable bowel syndrome (IBS) often associate their symptoms to certain foods. In congenital sucrase-isomaltase deficiency (CSID), recessive mutations in the SI gene (coding for disaccharidase digesting sucrose and 60% of dietary starch)1 cause clinical features IBS through colonic accumulation undigested carbohydrates, triggering symptoms.2 Hence, a previous study,3 we hypothesized that CSID variants reducing enzymatic activity may contribute development symptoms. We detected...
ABSTRACT Background Respiratory failure is a key feature of severe Covid-19 and critical driver mortality, but for reasons poorly defined affects less than 10% SARS-CoV-2 infected patients. Methods We included 1,980 patients with respiratory at seven centers in the Italian Spanish epicenters pandemic Europe (Milan, Monza, Madrid, San Sebastian Barcelona) genome-wide association analysis. After quality control exclusion population outliers, 835 1,255 population-derived controls from Italy,...
Objective Haemorrhoidal disease (HEM) affects a large and silently suffering fraction of the population but its aetiology, including suspected genetic predisposition, is poorly understood. We report first genome-wide association study (GWAS) meta-analysis to identify risk factors for HEM date. Design conducted GWAS 218 920 patients with 725 213 controls European ancestry. Using summary statistics, we performed multiple correlation analyses between other traits as well calculated polygenic...
Traditional cardiovascular risk factors, including hypertension, only explain part of major adverse cardiac events (MACEs). Understanding what other factors contribute to MACE is essential for prevention. Constipation shares common with hypertension and associated an increased several diseases. We hypothesized that constipation underappreciated factor MACE. used the population healthcare genomic data in UK Biobank (
Gut dysmotility is associated with constipation, diarrhea, and functional gastrointestinal disorders like irritable bowel syndrome (IBS), although its molecular underpinnings are poorly characterized. We studied stool frequency (defined by the number of movements per day, based on questionnaire data) as a proxy for gut motility in GWAS meta-analysis including 167,875 individuals from UK Biobank four smaller population-based cohorts. identify 14 loci (p ≤ 5.0 × 10−8). Gene set pathway...
Membrane contact sites between organelles are critical for the transfer of biomolecules. Lipid droplets store fatty acids and form contacts with mitochondria, which regulate acid oxidation adenosine triphosphate production. Protein compartmentalization at lipid droplet-mitochondria their effects on biological processes poorly described. Using proximity-dependent biotinylation methods, we identify 71 proteins sites, including a multimeric complex containing extended synaptotagmin (ESYT) 1,...
This study aimed to investigate the presence of plasma minichromosome maintenance complex component 6 (MCM6) mRNA and protein levels in hepatocellular carcinoma (HCC) patients evaluate their diagnostic value for HCC.Blood samples were collected from 61 HCC 29 cirrhotic patients, 30 healthy individuals. Circulating RNA was extracted all samples. The MCM6 amplified quantified by real-time polymerase chain reaction. Plasma α-fetoprotein (AFP) measured enzyme-linked immunosorbent assay.In...
Abstract Fermentation of dietary fibre by the gut microbiota leads to production metabolites called short-chain fatty acids (SCFAs), which have emerged as potent regulators immune, metabolic, and tissue barrier functions. More recently, a high diet SCFA supplementation were shown lower blood pressure be cardio-protective. SCFAs activate host signalling responses via receptors GPR41 GPR43, redundancy in their pathways. Whether these play role hypertension or mediate cardio-protective effects...
The Ca2+-activated Cl- channel, anoctamin 1 (Ano1, also known as transmembrane protein 16A) contributes to intestinal pacemaking, fluid secretion, cellular excitability, and tissue development. human ANO1 promoter contains binding sites for the glioma-associated oncogene (Gli) proteins. We investigated regulation of transcription by Gli. activity was determined using a luciferase reporter system. Binding functional effects Glis on expression were demonstrated chromatin immunoprecipitation,...