Frauke Degenhardt
A5034354112- Inflammatory Bowel Disease
- Genetic Associations and Epidemiology
- Immune Cell Function and Interaction
- SARS-CoV-2 and COVID-19 Research
- Celiac Disease Research and Management
- COVID-19 Clinical Research Studies
- T-cell and B-cell Immunology
- IL-33, ST2, and ILC Pathways
- vaccines and immunoinformatics approaches
- Dermatology and Skin Diseases
- Blood groups and transfusion
- Immunodeficiency and Autoimmune Disorders
- Erythrocyte Function and Pathophysiology
- Asthma and respiratory diseases
- Pelvic floor disorders treatments
- Gut microbiota and health
- Diabetes and associated disorders
- Renal Diseases and Glomerulopathies
- Helicobacter pylori-related gastroenterology studies
- Systemic Sclerosis and Related Diseases
- Monoclonal and Polyclonal Antibodies Research
- Assisted Reproductive Technology and Twin Pregnancy
- Hemoglobinopathies and Related Disorders
- PARP inhibition in cancer therapy
- Liver Disease Diagnosis and Treatment
Kiel University
2015-2023
University Hospital Schleswig-Holstein
2015-2023
University of Lübeck
2015-2023
Clinical Research Center Kiel
2021
Biogipuzkoa Health Research Institute
2020
Institute of Molecular Biology
2017-2019
University of Bonn
2016
Stanford University
2015
Medizinische Hochschule Hannover
1993-1995
There is considerable variation in disease behavior among patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes 2019 (Covid-19). Genomewide association analysis may allow for identification of potential genetic factors involved development Covid-19.
Machine learning methods and in particular random forests are promising approaches for prediction based on high dimensional omics data sets. They provide variable importance measures to rank predictors according their predictive power. If building a model is the main goal of study, often minimal set variables with good performance selected. However, if objective identification involved find active networks pathways, that aim select all relevant should be preferred. We evaluated several...
Increased levels of the urinary albumin-to-creatinine ratio (UACR) are associated with higher risk kidney disease progression and cardiovascular events, but underlying mechanisms incompletely understood. Here, we conduct trans-ethnic (n = 564,257) European-ancestry specific meta-analyses genome-wide association studies UACR, including ancestry- diabetes-specific analyses, identify 68 UACR-associated loci. Genetic correlation analyses score associations in an independent electronic medical...
Obesity is associated with hypothalamic inflammation (HI) in animal models. In the current study, we examined mediobasal hypothalamus (MBH) of 57 obese human subjects and 54 age- sex- matched nonobese control by MRI analyzed T2 hyperintensity as a measure HI. Obese exhibited left but not right MBH, which was strongly systemic low-grade inflammation. MRS revealed number neurons region to be similar versus subjects, suggesting functional structural impairment due inflammatory process. To gain...
Background. There is considerable variability in COVID-19 outcomes among younger adults, and some of this variation may be due to genetic predisposition.
Abstract Despite the increasing knowledge about factors shaping human microbiome, host genetic that modulate skin-microbiome interactions are still largely understudied. This contrasts with recent efforts to characterize genes influence gut microbiota. Here, we investigated effect of genetics on skin microbiota across three different microenvironments through meta-analyses genome-wide association studies (GWAS) two population-based German cohorts. We identified 23 significant loci harboring...
Natural killer (NK) cells are innate immune that contribute to host defense against virus infections. NK respond severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in vitro and activated patients with disease 2019 (COVID-19). However, by which mechanisms detect SARS-CoV-2-infected remains largely unknown. Here, we show the Non-structural protein 13 of SARS-CoV-2 encodes for a peptide is presented human leukocyte antigen E (HLA-E). In contrast self-peptides, viral prevents binding...
Objective One of the current hypotheses to explain proinflammatory immune response in IBD is a dysregulated T cell reaction yet unknown intestinal antigens. As such, it may be possible identify disease-associated clonotypes by analysing peripheral and T-cell receptor (TCR) repertoire patients with controls. Design We performed bulk TCR profiling both alpha beta chains using high-throughput sequencing blood samples total 244 healthy controls as well from matched tissue 59 disease further...
ABSTRACT Background Respiratory failure is a key feature of severe Covid-19 and critical driver mortality, but for reasons poorly defined affects less than 10% SARS-CoV-2 infected patients. Methods We included 1,980 patients with respiratory at seven centers in the Italian Spanish epicenters pandemic Europe (Milan, Monza, Madrid, San Sebastian Barcelona) genome-wide association analysis. After quality control exclusion population outliers, 835 1,255 population-derived controls from Italy,...
Because transethnic analysis may facilitate prioritization of causal genetic variants, we performed a genomewide association study (GWAS) psoriasis in South Asians (SAS), consisting 2,590 cases and 1,720 controls. Comparison with our existing European-origin (EUR) GWAS showed that effect sizes known signals were highly correlated SAS EUR (Spearman ρ = 0.78;
Abstract Protein-truncating variants protective against human disease provide in vivo validation of therapeutic targets. Here we used targeted sequencing to conduct a search for protein-truncating conferring protection inflammatory bowel exploiting knowledge common associated with the same disease. Through replication genotyping and imputation found that predicted variant (rs36095412, p.R179X, genotyped 11,148 ulcerative colitis patients 295,446 controls, MAF=up 0.78%) RNF186 , single-exon...
Genotype imputation of the human leukocyte antigen (HLA) region is a cost-effective means to infer classical HLA alleles from inexpensive and dense SNP array data. In research setting, helps avoid costs for wet lab-based typing thus renders association analyses in large cohorts feasible. Yet, most reference panels target Caucasian ethnicities multi-ethnic are scarce. We compiled high-quality panel based on genotypes measured with Illumina's Immunochip genotyping types established using...
Objective Haemorrhoidal disease (HEM) affects a large and silently suffering fraction of the population but its aetiology, including suspected genetic predisposition, is poorly understood. We report first genome-wide association study (GWAS) meta-analysis to identify risk factors for HEM date. Design conducted GWAS 218 920 patients with 725 213 controls European ancestry. Using summary statistics, we performed multiple correlation analyses between other traits as well calculated polygenic...