A5073979520- Inflammatory Bowel Disease
- Microscopic Colitis
- Immunodeficiency and Autoimmune Disorders
- Eosinophilic Esophagitis
- Neonatal Respiratory Health Research
- Adolescent and Pediatric Healthcare
- Childhood Cancer Survivors' Quality of Life
- Infant Nutrition and Health
- Cystic Fibrosis Research Advances
- Medical Image Segmentation Techniques
- Acute Lymphoblastic Leukemia research
- Pharmaceutical studies and practices
- Clinical Nutrition and Gastroenterology
- Nutrition and Health in Aging
- Intestinal Malrotation and Obstruction Disorders
- IL-33, ST2, and ILC Pathways
- Child Nutrition and Feeding Issues
- Autoimmune and Inflammatory Disorders Research
- Pregnancy and Medication Impact
- Celiac Disease Research and Management
- Birth, Development, and Health
- Helicobacter pylori-related gastroenterology studies
- Gastrointestinal disorders and treatments
- Digestive system and related health
- Asthma and respiratory diseases
Royal Hospital for Children
2015-2025
University of Edinburgh
2016-2025
Royal Hospital for Sick Children
2016-2025
Hospital for Sick Children
2000-2024
Centre for Inflammation Research
2023-2024
SickKids Foundation
1995-2023
University of Toronto
1995-2023
Nestlé (Switzerland)
2023
Nestlé Health Science (United States)
2023
NIHR Surgical Reconstruction and Microbiology Research Centre
2023
Crohn's disease and ulcerative colitis are complex disorders with some shared many unique predisposing genes. Accurate phenotype classification is essential in determining the utility of genotype-phenotype correlation. The Montreal Classification IBD has several weaknesses respect to children. dynamic features pediatric (change location behavior over time, growth failure) not sufficiently captured by current Classification. Focusing on facilitating research inflammatory bowel (IBD), creating...
The diagnosis of pediatric-onset inflammatory bowel disease (PIBD) can be challenging in choosing the most informative diagnostic tests and correctly classifying PIBD into its different subtypes. Recent advances our understanding natural history phenotype PIBD, increasing availability serological fecal biomarkers, emergence novel endoscopic imaging technologies taken together have made previous Porto criteria for obsolete.We aimed to revise original using an evidence-based approach consensus...
Children and adolescents with Crohn's disease (CD) present often a more complicated course compared to adult patients. In addition, the potential impact of CD on growth, pubertal emotional development patients underlines need for specific management strategy pediatric-onset CD. To develop first evidenced based consensus driven guidelines an expert panel 33 IBD specialists was formed after open call within European Colitis Organisation Society Pediatric Gastroenterolog, Hepatology Nutrition....
We aimed to provide an evidence-supported update of the ECCO-ESPGHAN guideline on medical management paediatric Crohn's disease [CD].
The contemporary management of ambulatory ulcerative colitis (UC) continues to be challenging with ∼20% children needing a colectomy within childhood years. We thus aimed standardize daily treatment pediatric UC and inflammatory bowel diseases (IBD)-unclassified through detailed recommendations practice points.These guidelines are joint effort the European Crohn's Colitis Organization (ECCO) Paediatric IBD Porto group Society Gastroenterology, Hepatology Nutrition (ESPGHAN). An extensive...
ABSTRACT Background and Aims: Pediatric ulcerative colitis (UC) shares many features with adult‐onset disease but there are some unique considerations; therefore, therapeutic approaches have to be adapted these particular needs. We aimed formulate guidelines for managing UC in children based on a systematic review (SR) of the literature robust consensus process. The present article is product joint effort European Crohn's Colitis Organization (ECCO) Society Paediatric Gastroenterology,...
An accurate indication of the changing incidence pediatric inflammatory bowel disease (PIBD) within a population is useful in understanding concurrent etiological factors. We aimed to compare current and other demographic attributes PIBD Scottish previous data.A national cohort prospectively retrospectively acquired incident cases diagnosed less than 16 years old services Scotland was captured for period 2003-2008; historical data were used comparison (1990-1995). Age/sex-adjusted incidences...
The clinical course and eventual outcome, or prognosis, of complex diseases varies enormously between affected individuals. This variability critically determines the impact a disease has on patient's life but is very poorly understood. Here, we exploit existing genome-wide association study data to gain insight into role genetics in prognosis. We identify noncoding polymorphism FOXO3A (rs12212067: T > G) at which minor (G) allele, despite not being associated with susceptibility, milder...
Objective IBD prevalence is estimated to be rising, but no detailed, recent UK data are available. The last reported estimate in the was 0.40% 2003. We aimed establish current, and project future, Lothian, Scotland. Design conducted an all-age multiparameter search strategy using inpatient international classification of disease (ICD-10) coding (K50/51)(1997–2018), pathology (1990–2018), primary secondary care prescribing (2009–2018) a paediatric registry, (1997–2018) identify ‘possible’...
BackgroundGermline variation in the 71 Crohn's disease (CD) loci implicated by genome-wide association studies (GWAS) only accounts for approximately 25% of estimated heritability. The contribution epigenetic alterations to pathogenesis is emerging as a research priority.
1.0 INTRODUCTION (1) Inflammatory bowel disease (IBD) encompasses 2 related but distinct disorders of as yet unknown aetiology. Crohn (CD) is a chronic, idiopathic, transmural inflammation that can affect 1 or several segments the digestive tract. Ulcerative colitis (UC) chronic idiopathic rectum extending continuously over variable length colon from distal end to proximal end. Indeterminate (IC) reserved for cases which findings are not sufficient allow differentiation between CD and UC...
Acute severe colitis (ASC) is one of the few emergencies in pediatric gastroenterology. Tight monitoring and timely medical surgical interventions may improve outcomes minimize morbidity mortality. We aimed to standardize daily treatment ASC children through detailed recommendations practice points which are based on a systematic review literature consensus experts.These guidelines joint effort European Crohn's Colitis Organization (ECCO) Society Paediatric Gastroenterology, Hepatology...
OBJECTIVES: Fecal calprotectin (FC) is elevated in patients with inflammatory bowel disease (IBD). Studies evaluating FC during the initial investigation of children suspected IBD have been limited, especially regard to their small patient groups. We aimed evaluate diagnostic accuracy a large regional cohort undergoing full upper and lower endoscopy for IBD, comparing six common blood parameters. METHODS: Using retrospective case–control design all measurements carried out between 2005 2010...
The incidence of Crohn disease (CD) has been increasing and surgery needs to be contemplated in a substantial number cases. relevant advent biological treatment changed but not eliminated the need for many patients. Despite previous publications on indications CD, there was comprehensive review existing evidence role elective options pediatric patients affected with CD. We present an expert opinion critical literature provide evidence-based guidance manage these Indications, surgical...