A5012979110- Inflammatory Bowel Disease
- Microscopic Colitis
- Eosinophilic Esophagitis
- Gastrointestinal disorders and treatments
- Pediatric Hepatobiliary Diseases and Treatments
- Immunodeficiency and Autoimmune Disorders
- Helicobacter pylori-related gastroenterology studies
- Adolescent and Pediatric Healthcare
- Gastroesophageal reflux and treatments
- Celiac Disease Research and Management
- Digestive system and related health
- Liver Diseases and Immunity
- Autoimmune and Inflammatory Disorders Research
- Infant Nutrition and Health
- Gallbladder and Bile Duct Disorders
- Pharmaceutical studies and practices
- Intestinal Malrotation and Obstruction Disorders
- Pregnancy and Medication Impact
- Congenital Anomalies and Fetal Surgery
- Intestinal and Peritoneal Adhesions
- Autoimmune and Inflammatory Disorders
- Gastrointestinal motility and disorders
- Tuberculosis Research and Epidemiology
- IL-33, ST2, and ILC Pathways
- Congenital gastrointestinal and neural anomalies
Norfolk and Norwich University Hospital
2023-2025
University of East Anglia
2023-2025
Barts Health NHS Trust
2020-2024
Queen Mary University of London
2022-2024
Ospedale Sant'Anna
2023
Royal London Hospital
2021-2022
Brunel University of London
2022
Addenbrooke's Hospital
2014-2021
Cambridge University Hospitals NHS Foundation Trust
2014-2021
University of Cambridge
2014-2020
We aimed to provide an evidence-supported update of the ECCO-ESPGHAN guideline on medical management paediatric Crohn's disease [CD].
We analyzed DNA methylation patterns and transcriptomes of primary intestinal epithelial cells (IEC) children newly diagnosed with inflammatory bowel diseases (IBD) to learn more about pathogenesis.We obtained mucosal biopsies (N = 236) collected from terminal ileum ascending sigmoid colons (median age 13 years) IBD (43 Crohn's disease [CD], 23 ulcerative colitis [UC]), 30 without (controls). Patients were recruited managed at a hospital in the United Kingdom 2013 through 2016. also later...
Inflammatory bowel disease [IBD] presenting in early childhood is extremely rare. More recently, progress has been made to identify children with monogenic forms of IBD predominantly very life. In this study, we describe the heterogeneous phenotypes and genotypes patients before age 2 years establish phenotypic features associated underlying monogenicity.Phenotype data 62 onset over past 20 were reviewed. Children without previously established genetic diagnosis prospectively recruited for...
Early-onset (EO) pediatric inflammatory bowel diseases (IBD) seem to be more extensive than those with a later onset. To test this hypothesis, we examined the phenotype and disease course of patients IBD diagnosis at 0 5 years, compared ranges 6 11 12 18 years.Anatomic locations behaviors were assessed according Paris classification in 506 consecutive patients: 224 Crohn's disease, 245 ulcerative colitis, 37 IBD-unclassified.Eleven percent range 39% 50% years. Ulcerative colitis was most...
Objective Epigenetic mechanisms, including DNA methylation (DNAm), have been proposed to play a key role in Crohn’s disease (CD) pathogenesis. However, the specific cell types and pathways affected as well their potential impact on phenotype outcome remain unknown. We set out investigate of intestinal epithelial DNAm CD Design generated 312 organoids (IEOs) from mucosal biopsies 168 patients with (n=72), UC (n=23) healthy controls (n=73). performed genome-wide molecular profiling DNAm, bulk...
There are scarce data available on upadacitinib in children with Crohn's disease (CD). To evaluate the effectiveness and safety of as an induction therapy paediatric CD. This was a multicentre retrospective study between 2022 2024 treated for remission active CD conducted 30 centres worldwide affiliated IBD Interest Porto group ESPGHAN. We recorded demographic, clinical laboratory adverse events (AEs) at week 8 post-induction. The analysis primary outcome based upon intention-to-treat (ITT)...
ABSTRACT Background and Objective: In recent decades, there has been a significant increase in the incidence of inflammatory bowel disease (IBD). It yet to be established whether manifestations IBD are similar paediatric adult ages. The objective this study was compare phenotypic expression between patients with childhood‐onset adulthood‐onset cases, all afferent same clinical centre. Patients Methods: Descriptive multivariate analyses were completed on retrospective prospective data...
DNA methylation is one of the major epigenetic mechanisms implicated in regulating cellular development and cell-type-specific gene expression. Here we performed simultaneous genome-wide expression analysis on purified intestinal epithelial cells derived from human fetal gut, healthy pediatric biopsies, children newly diagnosed with inflammatory bowel disease (IBD). Results were validated using pyrosequencing, real-time PCR, immunostaining. The functional impact changes was assessed by...
Abstract Background Data on upadacitinib therapy in children with ulcerative colitis (UC) or unclassified inflammatory bowel disease (IBD-U) are scarce. We aimed to evaluate the effectiveness and safety of as an induction pediatric UC IBD-U. Methods In this multicenter retrospective study, treated for remission active IBD-U from 30 centers worldwide were enrolled. Demographic, clinical laboratory data well adverse events (AEs) recorded at week 8 post induction. Results One hundred included...
Abstract Background Data on upadacitinib therapy in children with Crohn’s disease (CD) are scarce. We aimed to evaluate the effectiveness and safety of as an induction pediatric CD. Methods A multicenter retrospective study treated for remission active CD from 30 centers worldwide affiliated IBD Interest Porto group ESPGHAN between 2022 2024. Demographic, clinical, laboratory, imaging data well adverse events (AEs) were recorded at week 8 post induction. The analysis primary outcome was...
Background . Though Helicobacter pylori (HP) infections have progressively declined throughout most of the industrialized countries, a gradual increase in failure HP eradication treatments is observed. Aim To critically review evidence on efficacy therapeutic availabilities for eradication, as yet. Methods A selection Clinical Trials, Systematic Reviews and Meta-analyses within time period 2010–2012, was performed through Medline search. Previous references were included when basically...
Most children with Inflammatory Bowel Disease (IBD) are diagnosed between 11 and 16 years of age, commonly presenting features typical IBD. Children onset gut inflammation under 5 age often have a different underlying pathophysiology, one that is genetically phenotypically distinct from other We therefore set out to assess whether after the years, but before 11, clinical presentation outcome when compared those later.Retrospective cohort study conducted at two European Paediatric...
Faecal calprotectin (FCP) is a powerful tool to predict inflammatory bowel disease (IBD) in patients with gastrointestinal symptoms. In the paediatric patient population, reference value of < 50 μg/g and influence age on FCP levels result high number redundant investigations specialist referrals. We assessed levels, their diagnostic corresponding referral pathways from primary secondary care.We analysed two cohorts precisely defined catchment area: one consisted all FCPs measured this area...
Whether primary sclerosing cholangitis related to inflammatory bowel disease (PSC-IBD) diagnosed before 6 years (ie, VEO-IBD) has a distinct phenotype and course is uninvestigated. We aimed analyze the characteristics natural history of VEO-PSC-IBD, compared with early adolescent-onset PSC-IBD.
Background . Peptic ulcer disease (PUD) in children is reported worldwide, although it relatively rare as compared with adults. Helicobacter pylori (HP) infection a common cause of PUD the pediatric age. Other risk factors include use nonsteroidal anti-inflammatory agents (NSAIDs), steroids, immunosuppressive drugs, and stressful events. Aim To critically review evidence on epidemiology, diagnostic management, available treatments for Methods. A MEDLINE search was performed indicating...