Judith R. Kelsen
A5017288280- Inflammatory Bowel Disease
- Immunodeficiency and Autoimmune Disorders
- Microscopic Colitis
- Eosinophilic Esophagitis
- Clostridium difficile and Clostridium perfringens research
- Gut microbiota and health
- Helicobacter pylori-related gastroenterology studies
- IL-33, ST2, and ILC Pathways
- Immune Cell Function and Interaction
- Autoimmune and Inflammatory Disorders Research
- Inflammasome and immune disorders
- Gastrointestinal motility and disorders
- Adolescent and Pediatric Healthcare
- Mycobacterium research and diagnosis
- Autoimmune and Inflammatory Disorders
- Celiac Disease Research and Management
- Viral gastroenteritis research and epidemiology
- Whipple's Disease and Interleukins
- Digestive system and related health
- Genetic factors in colorectal cancer
- Liver Diseases and Immunity
- Diverticular Disease and Complications
- Gastrointestinal disorders and treatments
- Congenital gastrointestinal and neural anomalies
- Pharmaceutical studies and practices
Children's Hospital of Philadelphia
2016-2025
University of Pennsylvania
2016-2025
Philadelphia University
2014-2024
Hospital of the University of Pennsylvania
2017
Johns Hopkins University
2017
Johns Hopkins Medicine
2017
McCormick (United States)
2009
Inflammatory CD4(+) T cell responses to self or commensal bacteria underlie the pathogenesis of autoimmunity and inflammatory bowel disease (IBD), respectively. Although selection self-specific cells in thymus limits mammalian tissue antigens, mechanisms that control bacteria-specific remain poorly understood. Here, we demonstrate group 3 innate lymphoid (ILC3)-intrinsic expression major histocompatibility complex class II (MHCII) is regulated similarly thymic epithelial MHCII(+) ILC3s...
I nflammatory bowel disease (IBD) is a group of diseases that include Crohn's (CD) and ulcerative colitis (UC).Presenting symptoms therapeutic options are similar in adult pediatric patients.However, there significant differences the 2 populations require separate approaches to treatment management children.IBD now being recognized with increased frequency both adults children all ages.In CD, 25%-30% patients CD 20% (UC) present before age 20.Although peak onset still late adolescence, 4%...
The rate of pediatric inflammatory bowel disease (IBD) has been increasing over the last decade and this increase occurred most rapidly in youngest children diagnosed <6 years, known as very early-onset (VEO-IBD). These can present with more extensive severe than older adults. contribution host genetics population is underscored by young age onset distinct, aggressive phenotype. In fact, monogenic defects, often involving primary immunodeficiency genes, have identified VEO-IBD led to...
In these studies, we evaluated the contribution of NLRP3 inflammasome to Crohn's disease (CD) in a kindred containing individuals having missense mutation CARD8, protein known inhibit this inflammasome. Whole exome sequencing and PCR studies identified affected as V44I single allele T60 isoform CARD8. The serum levels IL-1β were increased compared with those healthy controls, their peripheral monocytes produced amounts when stimulated by activators. Immunoblot probing basis findings showed...
The pleiotropic actions of interleukin-2 (IL-2) are essential for regulation immune responses and maintenance tolerance. IL-2 receptor (IL-2R) is composed IL-2Rα, IL-2Rβ, IL-2Rγ subunits, with defects in IL-2Rα their downstream signaling effectors resulting known primary immunodeficiency disorders. Here, we report the first human defect occurring two infant siblings a homozygous IL2RB mutation WSXWS motif, manifesting as multisystem autoimmunity susceptibility to CMV infection. hypomorphic...
We describe humans with rare biallelic loss-of-function PTCRA variants impairing pre-α T cell receptor (pre-TCRα) expression. Low circulating naive αβ counts at birth persisted over time, normal memory and high γδ counts. Their TCRα repertoire was biased, which suggests that noncanonical thymic differentiation pathways can rescue development. Only a minority of these individuals were sick, infection, lymphoproliferation, and/or autoimmunity. also report 1 in 4000 from the Middle East South...
Abstract Objectives Real‐world data on ustekinumab for the treatment of pediatric Crohn's disease (CD) are limited. This study sought to evaluate effectiveness, long‐term durability, and safety in children with CD. Methods A retrospective longitudinal cohort CD treated from two large centers between 2015 2020 was performed. The primary outcome frequency steroid‐free clinical remission at 1 year. Secondary outcomes included time remission, biochemical drug escalation discontinuation, serum...
There are scarce data available on upadacitinib in children with Crohn's disease (CD). To evaluate the effectiveness and safety of as an induction therapy paediatric CD. This was a multicentre retrospective study between 2022 2024 treated for remission active CD conducted 30 centres worldwide affiliated IBD Interest Porto group ESPGHAN. We recorded demographic, clinical laboratory adverse events (AEs) at week 8 post-induction. The analysis primary outcome based upon intention-to-treat (ITT)...
The incidence and associated morbidity of Clostridium difficile (CD) infection has been increasing at an alarming rate in North America. difficile-associated diarrhea (CDAD) is the leading cause nosocomial USA. Patients with CDAD have longer average hospital admissions additional costs. Evidence demonstrated that patients inflammatory bowel disease (IBD) a higher CD comparison to general population. aim this study was compare recurrence hospitalized pediatric IBD compared controls. secondary...
Vedolizumab is effective for inducing and maintaining remission in adults with inflammatory bowel disease (IBD); however, there limited pediatric data. This study aimed to describe the adverse events clinical response vedolizumab refractory IBD.Disease activity indices, response, concomitant medication use, were measured over 22 weeks an observational prospective cohort of children IBD who had failed anti-tumor necrosis factor therapy subsequently initiated therapy.Twenty-one subjects, 16...
Abstract Background and Aims Dysbiosis of the gut microbiota is a well-known correlate pathogenesis inflammatory bowel disease [IBD]. However, few studies have examined microbiome in very early-onset [VEO] IBD, which defined as onset IBD before 6 years age. Here we focus on viral portion microbiome—the virome—to assess possible associations with processes, reasoning that any viruses potentially associated might grow more robustly younger subjects, so be detectable. Methods Virus-like...
The autoimmune disease systemic lupus erythematosus (SLE) has a modified epigenome with tri-methylation of histone H3 lysine 4 (H3K4me3) at specific loci across the genome. H3K4me3 is canonical chromatin mark active transcription. Recent studies have suggested that breadth an important regulatory role in cell identity. This project examined transcription start sites (TSS) primary monocytes and its association differential gene SLE. Integrative analysis was applied to immunoprecipitation...