A5026815496- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Gut microbiota and health
- SARS-CoV-2 and COVID-19 Research
- Immunotherapy and Immune Responses
- COVID-19 Clinical Research Studies
- IL-33, ST2, and ILC Pathways
- Psoriasis: Treatment and Pathogenesis
- Immunodeficiency and Autoimmune Disorders
- COVID-19 epidemiological studies
- SARS-CoV-2 detection and testing
- Diabetes and associated disorders
- Immune Response and Inflammation
- Immune cells in cancer
- Immune responses and vaccinations
- CAR-T cell therapy research
- Vaccine Coverage and Hesitancy
- Long-Term Effects of COVID-19
- Dermatology and Skin Diseases
- Tryptophan and brain disorders
- Monoclonal and Polyclonal Antibodies Research
- Cytokine Signaling Pathways and Interactions
- Immunotoxicology and immune responses
- Cancer Immunotherapy and Biomarkers
- Animal Virus Infections Studies
University of Lisbon
2017-2025
Babraham Institute
2011-2024
Instituto Gulbenkian de Ciência
2024
Instituto de Medicina Molecular João Lobo Antunes
2017-2022
Lusíada University of Lisbon
2021-2022
Bridge University
2021
Aga Khan University
2021
Los Alamos National Laboratory
2021
National Legal Medicine Institute
2017
Medical Research Council
2008-2011
Th17 cells are involved in the pathogenesis of many autoimmune diseases, but it is not clear whether they play a pathogenic role type 1 diabetes. Here we investigated mouse with specificity for an islet antigen can induce diabetes upon transfer into NOD/SCID recipient mice. Induction mice via adoptive Th1 from BDC2.5 transgenic was prevented by treatment neutralizing IFN-γ-specific antibody. This result suggested major induction disease this model Nevertheless, highly purified caused...
Th17 cell differentiation is dependent on interleukin (IL)-6 and transforming growth factor (TGF)-β, it modulated by activation of the aryl hydrocarbon receptor (AhR). In this study, we show that cells, but not Th1 or induced regulatory T (iT reg) increased endogenous AhR agonists present in culture medium. development from wild-type mice suboptimal presence antagonist CH-223191, similar to situation AhR-deficient mice, which attenuated IL-17 production no IL-22 production. The natural...
Abstract The recently discovered histone post-translational modification crotonylation connects cellular metabolism to gene regulation. Its regulation and tissue-specific functions are poorly understood. We characterize in intestinal epithelia find that H3 at lysine 18 is a surprisingly abundant the small intestine crypt colon, linked show this highly dynamic regulated during cell cycle. identify class I deacetylases, HDAC1, HDAC2, HDAC3, as major executors of decrotonylation. known HDAC...
CD4(+) T cells producing interleukin-10 (IL-10) and interferon-gamma (IFN-gamma) are reported in chronic infections. However, the signals that direct development of IL-10-producing helper 1 (Th1) undefined. We showed Th1 required high cell receptor (TCR) ligation, sustained ERK1 ERK2 MAP kinases phosphorylation, IL-12-induced STAT4 transcription factor activation. Repeated TCR triggering led to enhanced IL-10 production by cells, continued IL-12 action high-dose signaling were for...
Significance Tissue-resident memory T cells (T RM ) form in the skin where they are retained and can protect against subsequent infection. Using a combination of intravital imaging mathematical modeling that after cutaneous herpes simplex virus 1 infection, we reveal these persist at site infection for life mouse owing to slow random migration. We also report compete with dendritic epidermal γδ local survival signals, suggesting space within an niche.
SARS-CoV-2 has emerged as a human pathogen, causing clinical signs, from fever to pneumonia-COVID-19-but may remain mild or asymptomatic. To understand the continuing spread of virus, detect those who are and were infected, follow immune response longitudinally, reliable robust assays for detection immunological monitoring needed. We quantified IgM, IgG, IgA antibodies recognizing receptor-binding domain (RBD) Spike (S) protein over period 6 months following COVID-19 onset. report detailed...
Abstract The gastrointestinal tract is continuously exposed to many environmental factors that influence intestinal epithelial cells and the underlying mucosal immune system. In this article, we demonstrate dietary fiber short chain fatty acids (SCFAs) induced expression of vitamin A–converting enzyme RALDH1 in vivo vitro, respectively. Furthermore, our data showed levels small correlated with activity enzymes mesenteric lymph node dendritic cells, along increased numbers regulatory T a...
There is a consensus that mass vaccination against SARS-CoV-2 will ultimately end the COVID-19 pandemic. However, it not clear when and which control measures can be relaxed during rollout of programmes. We investigate relaxation scenarios using an age-structured transmission model has been fitted to age-specific seroprevalence data, hospital admissions, projected coverage for Portugal. Our analyses suggest pressing need restart socioeconomic activities could lead new pandemic waves,...
Macrophages provide a bridge linking innate and adaptive immunity. An increased frequency of macrophages other myeloid cells paired with excessive cytokine production is commonly seen in the aging immune system, known as ‘inflamm-aging'. It presently unclear how healthy are maintained throughout life what connects inflammation dysfunction during aging. Autophagy, an intracellular degradation mechanism, has links lifespan extension. Here, we show for first time that autophagy regulates...