A5066993086- Immune Cell Function and Interaction
- IL-33, ST2, and ILC Pathways
- Research on Leishmaniasis Studies
- T-cell and B-cell Immunology
- Eosinophilic Esophagitis
- Asthma and respiratory diseases
- Immunotherapy and Immune Responses
- Trypanosoma species research and implications
- Immune Response and Inflammation
- Parasites and Host Interactions
- Studies on Chitinases and Chitosanases
- Mast cells and histamine
- Urticaria and Related Conditions
- Toxin Mechanisms and Immunotoxins
- Psoriasis: Treatment and Pathogenesis
- Insect symbiosis and bacterial influences
- Monoclonal and Polyclonal Antibodies Research
- Invertebrate Immune Response Mechanisms
- CAR-T cell therapy research
- Immune cells in cancer
- Biochemical Analysis and Sensing Techniques
- Adipokines, Inflammation, and Metabolic Diseases
- Autoimmune and Inflammatory Disorders Research
- T-cell and Retrovirus Studies
- Glycosylation and Glycoproteins Research
University of California, San Francisco
2016-2025
Howard Hughes Medical Institute
2016-2025
University of California System
2003-2024
University of San Francisco
2022
Icahn School of Medicine at Mount Sinai
2018
UCSF Helen Diller Family Comprehensive Cancer Center
2016-2017
Genetics and IVF Institute
2017
American Asthma Foundation
2015
University of Iowa
2015
University of Washington
1982-2014
The pathogenesis of asthma reflects, in part, the activity T cell cytokines. Murine models support participation interleukin-4 (IL-4) and IL-4 receptor asthma. Selective neutralization IL-13, a cytokine related to that also binds α chain receptor, ameliorated phenotype, including airway hyperresponsiveness, eosinophil recruitment, mucus overproduction. Administration either IL-13 or conferred an asthma-like phenotype nonimmunized cell–deficient mice by chain–dependent pathway. This pathway...
We purified poly(A)+ mRNA from the spleen and lymph nodes at designated times after infection with Leishmania major in genetically susceptible BALB/c resistant C57BL/6 mice. The steady-state levels of IL-2, IFN-gamma, IL-4, IL-1 beta were determined using Northern hybridizations. IL-2 infected organs mice comparable infection, but IFN-gamma IL-4 reciprocally expressed. Levels draining significantly greater than except 4 6 wk when splenic transiently comparable. In contrast, was apparent only...
Eosinophils are associated with helminth immunity and allergy, often in conjunction alternatively activated macrophages (AAMs). Adipose tissue AAMs necessary to maintain glucose homeostasis induced by the cytokine interleukin-4 (IL-4). Here, we show that eosinophils major IL-4-expressing cells white adipose tissues of mice, and, their absence, greatly attenuated. migrate into an integrin-dependent process reconstitute through IL-4- or IL-13-dependent process. Mice fed a high-fat diet develop...
Type 2 immunity is a stereotyped host response to allergens and parasitic helminths that sustained in large part by the cytokines IL-4 IL-13. Recent advances have called attention contributions innate cells initiating adaptive immunity, including novel lineage-negative population of secretes IL-13 IL-5 epithelial IL-25 IL-33. Here, we use reporter mice track arise during type or IL-33 vivo. Unexpectedly, (and IL-33) responsive are widely distributed tissues mouse particularly prevalent...
Eosinophils in visceral adipose tissue (VAT) have been implicated metabolic homeostasis and the maintenance of alternatively activated macrophages (AAMs). The absence eosinophils can lead to adiposity systemic insulin resistance experimental animals, but what maintains is unknown. We show that interleukin-5 (IL-5) deficiency profoundly impairs VAT eosinophil accumulation results increased when animals are placed on a high-fat diet. Innate lymphoid type 2 cells (ILC2s) resident major source...
Long-range regulatory elements are difficult to discover experimentally; however, they tend be conserved among mammals, suggesting that cross-species sequence comparisons should identify them. To search for sequences, we examined about 1 megabase of orthologous human and mouse sequences noncoding with greater than or equal 70% identity over at least 100 base pairs. Ninety meeting these criteria were discovered, the analysis 15 found across mammals. Characterization largest element in yeast...
Reversible airway hyperreactivity underlies the pathophysiology of asthma, yet precise mediators response remain unclear. Human studies have correlated aberrant activation T helper (Th) 2-like effector systems in airways with disease. A murine model to acetylcholine was established using mice immunized ovalbumin and challenged aerosolized antigen. No hyperractivity occurred severe combined immunodeficient mice. Identically BALB/c developed an influx cells, a predominance eosinophils CD4+...
BALB/c mice infected with Leishmania major develop fatal, progressive disease, despite an immune response characterized by expansion of CD4+ T cells in the draining lymph nodes. The has been further a lack IFN-gamma mRNA, but increased IL-4 mRNA lymphoid tissues, and striking elevation serum IgE. Treatment rIFN-gamma at doses shown to be beneficial other protozoan infections was insufficient ameliorate L. infection. In contrast, neutralization six weekly injections mAb 11B11 led attenuation...