A5066684344- IL-33, ST2, and ILC Pathways
- Immune Cell Function and Interaction
- Eosinophilic Esophagitis
- Legionella and Acanthamoeba research
- Neuroinflammation and Neurodegeneration Mechanisms
- Neonatal Respiratory Health Research
- Asthma and respiratory diseases
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Pulmonary Hypertension Research and Treatments
- Heme Oxygenase-1 and Carbon Monoxide
- Reproductive System and Pregnancy
- Vibrio bacteria research studies
- Adipokines, Inflammation, and Metabolic Diseases
- Parasites and Host Interactions
- Congenital Diaphragmatic Hernia Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Erythrocyte Function and Pathophysiology
- Pediatric health and respiratory diseases
- Lymphoma Diagnosis and Treatment
- Tumors and Oncological Cases
- MicroRNA in disease regulation
- Helicobacter pylori-related gastroenterology studies
- Pain Mechanisms and Treatments
- Immune Response and Inflammation
- Lymphatic System and Diseases
University of California, San Francisco
2016-2025
University of California System
2024
Diabetes Care Center
2020
Universidad Católica de Santa Fe
2019
University of Washington
2019
University of California San Francisco Medical Center
2017
University of Copenhagen
2017
Howard Hughes Medical Institute
2013-2014
University of Michigan
2003-2014
Laboratory of Molecular Genetics
2014
Eosinophils are associated with helminth immunity and allergy, often in conjunction alternatively activated macrophages (AAMs). Adipose tissue AAMs necessary to maintain glucose homeostasis induced by the cytokine interleukin-4 (IL-4). Here, we show that eosinophils major IL-4-expressing cells white adipose tissues of mice, and, their absence, greatly attenuated. migrate into an integrin-dependent process reconstitute through IL-4- or IL-13-dependent process. Mice fed a high-fat diet develop...
Eosinophils in visceral adipose tissue (VAT) have been implicated metabolic homeostasis and the maintenance of alternatively activated macrophages (AAMs). The absence eosinophils can lead to adiposity systemic insulin resistance experimental animals, but what maintains is unknown. We show that interleukin-5 (IL-5) deficiency profoundly impairs VAT eosinophil accumulation results increased when animals are placed on a high-fat diet. Innate lymphoid type 2 cells (ILC2s) resident major source...
Call to action The developing brain initially makes more synapses than it needs. With further development, excess are pruned away, leaving mature circuits. Synapses can be eliminated by microglia, which engulf and destroy them. Vainchtein et al. found that the microglia called into astrocytes, supportive cells on neurons rely. Astrocytes near a redundant synapse release cytokine interleukin-33 (IL-33), recruits site. In mice, disruptions in this process, as caused deficiency IL-33, led too...
To restrict infection by Legionella pneumophila, mouse macrophages require Naip5, a member of the nucleotide-binding oligomerization domain leucine-rich repeat family pattern recognition receptors, which detect cytoplasmic microbial products. We report that restricted L. pneumophila replication and initiated proinflammatory program cell death when flagellin contaminated their cytosol. Nuclear condensation, membrane permeability, interleukin-1β secretion were triggered type IV...
We engineered an ultrasensitive reporter of
Microglia are brain-resident macrophages that shape neural circuit development and implicated in neurodevelopmental diseases. Multiple microglial transcriptional states have been defined, but their functional significance is unclear. Here, we identify a type I interferon (IFN-I)-responsive state the developing somatosensory cortex (postnatal day 5) actively engulfing whole neurons. This population expands during cortical remodeling induced by partial whisker deprivation. Global or...
Summary Legionella pneumophila can replicate inside amoebae and also alveolar macrophages to cause Legionnaires’ Disease in susceptible hosts. When nutrients become limiting, a stringent‐like response coordinates the differentiation of L. transmissive form, process mediated by two‐component system LetA/S sigma factors RpoS FliA. Here we demonstrate that broadly conserved RNA binding protein CsrA is global repressor transmission phenotypes an essential activator intracellular replication. By...
Peripheral nerve injury-induced neuropathic pain is a chronic and debilitating condition characterized by mechanical hypersensitivity. We previously identified microglial activation via release of colony-stimulating factor 1 (CSF1) from injured sensory neurons as mechanism contributing to pain. Here, we show that intrathecal administration CSF1, even in the absence injury, sufficient induce behavior, but only male mice. Transcriptional profiling morphologic analyses after CSF1 showed robust...
Inflammation and dysfunction of the extrahepatic biliary tree are common causes human pathology, including gallstones cholangiocarcinoma. Despite this, we know little about local regulation inflammation. Tuft cells, rare sensory epithelial particularly prevalent in mucosa gallbladder bile ducts. Here, show that tuft cells express a core genetic cell program addition to tissue-specific gene signature and, contrast small intestinal decreased postnatally, coincident with maturation acid...