A5039654372- Immune Cell Function and Interaction
- IL-33, ST2, and ILC Pathways
- Cognitive Abilities and Testing
- Demographic Trends and Gender Preferences
- Evolutionary Psychology and Human Behavior
- T-cell and B-cell Immunology
- Neuroendocrine regulation and behavior
- Early Childhood Education and Development
- Signaling Pathways in Disease
- Asthma and respiratory diseases
- Stress Responses and Cortisol
- HIV Research and Treatment
- Medical Malpractice and Liability Issues
- Reproductive Biology and Fertility
- Endoplasmic Reticulum Stress and Disease
- Human Health and Disease
- Epigenetics and DNA Methylation
- Child Development and Digital Technology
- Autophagy in Disease and Therapy
- Birth, Development, and Health
- Atherosclerosis and Cardiovascular Diseases
Columbia University
2018-2023
University of California, San Francisco
2020-2021
University of California San Francisco Medical Center
2021
Gladstone Institutes
2020
The paternal transmission of environmentally induced phenotypes across generations has been reported to occur following a number qualitatively different exposures and appear be driven, at least in part, by epigenetic factors that are inherited via the sperm. However, previous studies germline have not addressed role mothers propagation effects offspring. We hypothesized exposure nutritional restriction would impact male mate quality subsequent maternal reproductive investment with...
Abstract Quiescence is a hallmark of CD4 + T cells latently infected with HIV-1. While reversing this quiescence an effective approach to reactivate latent HIV from in culture, it can cause deleterious cytokine dysregulation patients. Here we report that FOXO1, key regulator T-cell quiescence, promotes latency and suppresses productive infection. In resting cells, FOXO1 inhibition induces ER stress activates two associated transcription factors: activating factor 4 (ATF4) nuclear activated...
Androgens promote inflammation in visceral adipose tissue (VAT), leading to the expansion of a distinct IL-33 producing stromal population and recruitment T regs .
Abstract Paternal stress exposure is known to impact the development of stress-related behaviors in offspring. Previous work has highlighted importance sperm mediated factors, such as RNAs, transmitting effects parental stress. However, a key unanswered question whether mothers’ behavior could drive or modulate transmission paternal on offspring development. Here we investigate how chronic variable Balb/C mice influences sex-specific anxiety- and depression-like neural behavioral Moreover,...
INTRODUCTION: Decision-to-Incision (DTI) research has investigated maternal and neonatal outcomes, while literature on decreasing DTI times remains sparse. Here we describe a quality improvement project, led by first-year medical students, aimed at reducing county hospital using worksheet to guide communication during interdisciplinary huddles before each unplanned cesarean. METHODS: In 2017, students Zuckerberg San Francisco General Hospital implemented grading system standardize the...
Abstract Many allergic diseases originate during early life and cause chronic inflammation that persists into adulthood. Immune dysregulation the “critical window” of postnatal development has been hypothesized to establish lifelong susceptibility inflammation; however, mechanistic evidence is lacking. Regulatory T cells (Tregs) are critical suppressors autoimmunity functionally unique life. We have found neonatal Tregs (neoTregs) suppress profound dysfunction skin immunity stromal...
Abstract Tissue inflammation early in life can be imprinted on the immune system, causing lasting changes immunologic tone that confer disease protection or susceptibility adults. The cellular and molecular mechanisms responsible for imprinting many nonlymphoid tissues remain largely unknown. We find time-limited neonatal induced by transient reduction of regulatory T cells (Tregs) causes a dramatic dysregulation skin stromal cells, accompanied selective accumulation Th2 within distinct...