A5080860043- Immune Cell Function and Interaction
- IL-33, ST2, and ILC Pathways
- Eosinophilic Esophagitis
- T-cell and B-cell Immunology
- Asthma and respiratory diseases
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Urticaria and Related Conditions
- Dermatology and Skin Diseases
- Cytokine Signaling Pathways and Interactions
- Parasites and Host Interactions
- Psoriasis: Treatment and Pathogenesis
- Virus-based gene therapy research
- Immune Response and Inflammation
- Mast cells and histamine
- RNA Interference and Gene Delivery
- Immune cells in cancer
- Immunodeficiency and Autoimmune Disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Helicobacter pylori-related gastroenterology studies
- Studies on Chitinases and Chitosanases
- NF-κB Signaling Pathways
- DNA Repair Mechanisms
- Mercury impact and mitigation studies
- RNA Research and Splicing
University of California, San Francisco
2015-2025
Howard Hughes Medical Institute
2008-2022
Parker Institute for Cancer Immunotherapy
2021
Neurological Surgery
2021
Broad Center
2021
Cardiovascular Institute Hospital
2015
Bipar
2010-2013
Pediatrics and Genetics
2013
City College of San Francisco
2011
National Taiwan University
1998-2004
Eosinophils are associated with helminth immunity and allergy, often in conjunction alternatively activated macrophages (AAMs). Adipose tissue AAMs necessary to maintain glucose homeostasis induced by the cytokine interleukin-4 (IL-4). Here, we show that eosinophils major IL-4-expressing cells white adipose tissues of mice, and, their absence, greatly attenuated. migrate into an integrin-dependent process reconstitute through IL-4- or IL-13-dependent process. Mice fed a high-fat diet develop...
Type 2 immunity is a stereotyped host response to allergens and parasitic helminths that sustained in large part by the cytokines IL-4 IL-13. Recent advances have called attention contributions innate cells initiating adaptive immunity, including novel lineage-negative population of secretes IL-13 IL-5 epithelial IL-25 IL-33. Here, we use reporter mice track arise during type or IL-33 vivo. Unexpectedly, (and IL-33) responsive are widely distributed tissues mouse particularly prevalent...
Eosinophils in visceral adipose tissue (VAT) have been implicated metabolic homeostasis and the maintenance of alternatively activated macrophages (AAMs). The absence eosinophils can lead to adiposity systemic insulin resistance experimental animals, but what maintains is unknown. We show that interleukin-5 (IL-5) deficiency profoundly impairs VAT eosinophil accumulation results increased when animals are placed on a high-fat diet. Innate lymphoid type 2 cells (ILC2s) resident major source...
Programs defining tissue-resident macrophage identity depend on local environmental cues. For alveolar macrophages (AMs), these signals are provided by immune and nonimmune cells include GM-CSF (CSF2). However, evidence to functionally link components of this intercellular cross talk remains scarce. We thus developed new transgenic mice profile pulmonary expression, which we detected in both cells, including group 2 innate lymphoid γδ T as well AT2s. AMs were unaffected constitutive deletion...
Abstract Naive T lymphocytes acquire a phenotype similar to Ag-experienced memory cells as result of proliferation under lymphopenic conditions. Such “memory-like” (TML) constitute large fraction the peripheral cell pool in patients recovering from ablative therapies, HIV highly active antiretroviral therapy, and elderly population. To generate model that allows characterization TML without adoptive transfer, irradiation, or thymectomy, we developed genetically modified mice express...
Group 2 innate lymphoid cells (ILC2s) are tissue-resident prominent at barrier sites. Although precursors found in blood, mature ILC2s can enter the circulation after small intestinal perturbation by migratory helminths and move to distant tissues influence local reparative response. Using fate-mapping methods bypass lung or phases of Nippostrongylus brasiliensis infection, we show that blood comprise heterogeneous populations derived from distinct dependent on alarmins matched receptor...