A5035436135- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Retinoids in leukemia and cellular processes
- Neurological disorders and treatments
- Mesenchymal stem cell research
- Cancer therapeutics and mechanisms
- Multiple Myeloma Research and Treatments
- T-cell and B-cell Immunology
- RNA Interference and Gene Delivery
- Platelet Disorders and Treatments
- Eosinophilic Disorders and Syndromes
- Hemophilia Treatment and Research
- Mental Health and Psychiatry
- Blood Coagulation and Thrombosis Mechanisms
- Schizophrenia research and treatment
- Neutropenia and Cancer Infections
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Immunodeficiency and Autoimmune Disorders
- Mycobacterium research and diagnosis
- Immune cells in cancer
- Monoclonal and Polyclonal Antibodies Research
- Chronic Lymphocytic Leukemia Research
Gladstone Institutes
2025
University of California, San Francisco
2025
Centre de Recherche en Cancérologie de Marseille
2020-2024
Immunité et Cancer
2021-2023
Université de Montpellier
2022
Aix-Marseille Université
2021-2022
Inserm
2021-2022
Centre National de la Recherche Scientifique
2021-2022
Hôpital Cardiologique du Haut-Lévêque
1991-1999
Université de Limoges
1997
Abstract The antibody Ki67 is currently used to evaluate the proliferative fraction of solid tumors and some hematological malignancies. We have phytohemagglutinin (PHA)‐stimulated peripheral blood lymphocytes as a model study entry quiescent cells into cell cycle follow their progress next cycle. Flow cytometric analysis lymphocyte samples stained with DNA marker has allowed us expression antigen (Ki67Ag) function position in use drugs blocking stimulated different phases permitted...
The success and limitations of current immunotherapies have pushed research toward the development alternative approaches possibility to manipulate other cytotoxic immune cells such as natural killer (NK) cells. Here, we targeted an intracellular inhibiting protein 'cytokine inducible SH2-containing protein' (CISH) in NK evaluate impact on their functions antitumor properties.To further understand CISH cells, developed a conditional Cish-deficient mouse model (Cishfl/flNcr1Ki/+ ). cytokine...
We retrospectively studied the factors affecting rate of hematopoietic reconstitution (HR) in 118 patients with hematological malignancies who underwent peripheral blood progenitor cell (PBPC) transplantation at a single institution. The received median number 6.6 x 108 nucleated cells/kg corresponding to 9.5 104 (0.5-578) CFU-GM/kg and 6.8 106 (0.2-161) CD34-positive cells/kg. days reach 500 polymorphonuclear cells/mm3 50,000 platelets/mm3 was 12.5 (6-93) 14.5 (6-440) days, respectively. No...
Targeting intracellular inhibiting proteins has been revealed to be a promising strategy improve CD8
PURPOSE The aims of the current study were to evaluate in patients with high-risk multiple myeloma (MM) feasibility and usefulness high-dose chemotherapy or chemoradiotherapy followed by hematopoietic stem-cell support autologous peripheral-blood progenitor cells (PBPC) harvested after cyclophosphamide (HDCYC). PATIENTS AND METHODS Seventy-three MM entered onto study. Before procedure, all had received HDCYC collect PBPC leukapheresis. One patient died infection HDCYC. All other subsequently...
Summary We isolated a Rhizobium leguminosarum mutant strain altered in the glnB gene. This event, which has never been described Rhizobiaceae, is rare comparison to mutants contiguous gene, glnA. The mutation removes glnBA promoter but vivo does not prevent glnA expression from its own promoter, nitrogen regulated. grow on nitrate as sole source and it Nod + , Fix . Two –24/–12 promoters, for glnll genes, are constitutively expressed mutant, while two –35/–10‐like promoters ntrBC unaffected....
The aim of the present study was to evaluate relative performance five screening methods for APC resistance caused by factor V:Q506 mutation: original method Coatest Resistance Chromogenix, a modified using same reagents but predilution 1+4 plasma in V deficient from Stago (Stago V) or Chromogenix (V-DEF Plasma), (Chromogenix), and Accélérimat bioMérieux. Normalization done against pool normal plasmas Chromogenix. included 350 subjects, 219 were genotyped (174 FV:R506R, 42 FV:Q506R, 3...
Some forms of chemoresistance in leukemia may start from failure tumour cells to successfully undergo apoptosis and Bcl-2 play a role this defect. Therefore, we evaluated the content synthesis relation with apoptotic potential leukemic cell lines after anthracycline treatment.U937, HL60, K562 their drug resistant (DR) variants were treated varying concentrations Idarubicin (IDA). Apoptosis was by fluorescence microscopy acridine orange staining. Bax either flow cytometry indirect...
Summary In 22 cases of chronic ITP, the platelet 5-HT storage organelles were counted by examination platelets loaded with mepacrine and correlated size volume platelets. Statistical analysis showed that mean number granules increased in ITP without increase per unit volume. A strong correlation was found between long diameter dense bodies controls (44 healthy subjects) (r = 0.94; y 2.826 × – 0.699) 0.92; 2.587 + 0.06). This study demonstrated presence both others rich granules. These...