A5082369585- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- IL-33, ST2, and ILC Pathways
- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Reproductive System and Pregnancy
- Immune Response and Inflammation
- Eosinophilic Esophagitis
- Cytokine Signaling Pathways and Interactions
- Inflammatory Biomarkers in Disease Prognosis
- Phagocytosis and Immune Regulation
- Cancer-related molecular mechanisms research
- Hematopoietic Stem Cell Transplantation
- Ferroptosis and cancer prognosis
- Adenosine and Purinergic Signaling
- Peptidase Inhibition and Analysis
- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- Click Chemistry and Applications
- Single-cell and spatial transcriptomics
- CRISPR and Genetic Engineering
- interferon and immune responses
- Autophagy in Disease and Therapy
Monash University
2019-2025
The University of Melbourne
2014-2024
Walter and Eliza Hall Institute of Medical Research
2013-2024
Australian Regenerative Medicine Institute
2019-2024
Discovery Institute
2020-2023
Innate Pharma (France)
2020
The University of Queensland
2015-2020
Translational Research Institute
2020
Rockefeller University
2020
ORCID
2020
Blocking TGF-β signaling in natural killer cells enhances their metabolism and ability to kill tumor cells.
The in vivo requirements for human natural killer (NK) cell development and differentiation into cytotoxic effectors expressing inhibitory receptors self–major histocompatability complex class I (MHC-I; Ig-like [KIRs]) remain undefined. Here, we dissect the role of interleukin (IL)-15 NK using Rag2−/−γc−/− mice transplanted with hematopoietic stem cells. Human reconstitution was intrinsically low this model because poor reactivity to mouse IL-15. Although exogenous IL-15 (hIL-15) alone made...
Extracellular adenosine is a key immunosuppressive metabolite that restricts activation of cytotoxic lymphocytes and impairs antitumor immune responses. Here, we show engagement A2A receptor (A2AR) acts as checkpoint limits the maturation natural killer (NK) cells. Both global NK-cell-specific conditional deletion A2AR enhanced proportions terminally mature NK cells at homeostasis, following reconstitution, in tumor microenvironment. Notably, A2AR-deficient, retained proliferative capacity...
Abstract NK cells are important for the clearance of tumors, parasites, and virus-infected cells. Thus, factors that control cell numbers function critical innate immune response. A subset express inhibitory killer lectin-like receptor G1 (KLRG1). In this study, we identify KLRG1 expression is acquired during periods division such as development homeostatic proliferation. KLRG1+ mature in phenotype, show first time these have a slower vivo turnover rate, reduced proliferative response to...
Natural killer (NK) cell activity is essential for initiating antitumor responses and may be linked to immunotherapy success. NK cells other innate immune components could exploitable cancer treatment, which drives the need tools methods that identify therapeutic avenues. Here, we extend our gene-set scoring method singscore investigate infiltration by applying RNA-seq analysis samples from bulk tumors. Computational have been developed deconvolution of types within solid We taken gene...
Innate lymphoid cell (ILC) populations protect against infection and are essential for tissue formation remodeling after damage. Nfil3 is implicated in the function of adaptive immune lineages NK development, but it not yet known if regulates other innate lineages. Here, we identify that development Peyer’s patches ILC2 ILC3 subsets. Loss selectively reduced patch was accompanied by impaired recruitment distribution lymphocytes within patches. ILC subsets exhibited high expression genetic...
Abstract The contribution of mast cells in the microenvironment solid malignancies remains controversial. Here we functionally assess impact tumor-adjacent, submucosal cell accumulation murine and human intestinal-type gastric cancer. We find that genetic ablation or therapeutic inactivation suppresses tumor-associated macrophages, reduces tumor proliferation angiogenesis, diminishes burden. Mast are activated by interleukin (IL)-33, an alarmin produced epithelium response to inflammatory...
Abstract Multipotent mesenchymal stromal cells (MSCs) ameliorate a wide range of diseases in preclinical models, but the lack clarity around their mechanisms action has impeded clinical utility. The therapeutic effects MSCs are often attributed to bioactive molecules secreted by viable MSCs. However, we found that underwent apoptosis lung after intravenous administration, even absence host cytotoxic or alloreactive cells. Deletion apoptotic effectors BAK and BAX prevented MSC death...