A5029369144- Immune Cell Function and Interaction
- Cytomegalovirus and herpesvirus research
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- IL-33, ST2, and ILC Pathways
- Herpesvirus Infections and Treatments
- Hematopoietic Stem Cell Transplantation
- Inflammasome and immune disorders
- Autoimmune and Inflammatory Disorders Research
- Immune Response and Inflammation
- Cancer Immunotherapy and Biomarkers
- Cell death mechanisms and regulation
- HER2/EGFR in Cancer Research
- Mast cells and histamine
- Toxoplasma gondii Research Studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Bladder and Urothelial Cancer Treatments
- Protein Kinase Regulation and GTPase Signaling
- CAR-T cell therapy research
- RNA modifications and cancer
- Mosquito-borne diseases and control
- RNA Interference and Gene Delivery
- Carbohydrate Chemistry and Synthesis
- Legionella and Acanthamoeba research
- Peptidase Inhibition and Analysis
Australian Regenerative Medicine Institute
2019-2025
Monash University
2019-2025
Lions Eye Institute
2016-2025
The University of Western Australia
2011-2023
Discovery Institute
2020
Brigham and Women's Hospital
1997-2002
Harvard University
1997-2002
Woman's Hospital
1998
Effective vaccine adjuvants must induce expression of major histocompatibility (MHC) class II proteins and the costimulatory molecule CD86 on dendritic cells (DCs). However, some elicit production cytokines resulting in adverse inflammatory consequences. Development agents that selectively increase MHC without triggering unwanted cytokine requires a better understanding molecular mechanisms influencing degradation DCs. Here, we investigate how CD83, an immunoglobulin protein expressed...
Effective immunity requires the coordinated activation of innate and adaptive immune responses. Natural killer (NK) cells are central effectors, but can also affect generation acquired responses to viruses malignancies. How NK influence efficacy immunity, however, is poorly understood. Here, we show that negatively regulate duration effectiveness virus-specific CD4+ CD8+ T cell by limiting exposure infected antigen-presenting cells. This impacts quality ability limit viral persistence. Our...
Dendritic cells (DCs) play a predominant role in activation of natural killer (NK) that exert their functions against pathogen-infected and tumor cells. Here, we used murine model to investigate the molecular mechanisms responsible for this process. Two soluble molecules produced by bacterially activated myeloid DCs are required optimal priming NK Type I interferons (IFNs) promote cytotoxic IL-2 is necessary both vitro vivo efficient production IFNγ, which has an important antimetastatic...
The proto-oncogene product Cbl has emerged as a potential negative regulator of the Syk tyrosine kinase; however, nature physical interactions between and that are critical for this regulation remains unclear. Here we show phosphotyrosine-binding (PTB) domain within N-terminal transforming region (Cbl-N) binds to phosphorylated Tyr323in linker Src homology 2 kinase domains Syk, confirming recent results by another laboratory using yeast two-hybrid approach (Deckert, M., Elly, C., Altman, A.,...
Natural killer (NK) cells are naturally circulating innate lymphoid that protect against tumor initiation and metastasis contribute to immunopathology during inflammation. The signals prime NK not completely understood, and, although the importance of IFN type I is well recognized, role III comparatively very poorly studied. IL-28R-deficient mice were resistant LPS cecal ligation puncture-induced septic shock, hallmark cytokines in these disease models dysregulated absence IL-28R. more...
Serotherapy treats a transplant hurdle Cytomegalovirus (CMV) infection and reactivation are common potentially fatal complications after bone marrow or hematopoietic stem cell transplantation (BMT). Martins et al. developed faithful preclinical murine models of CMV following BMT found that humoral immunity can prevent this process (see the Perspective by Alegre). After BMT, antiviral antibodies would have kept at bay dwindle because host plasma cells ablated donor B pool reconstitutes...
AbstractFyn is a prototype Src-family tyrosine kinase that plays specific roles in neural development, keratinocyte differentiation, and lymphocyte activation, as well redundant with other kinases. Similar to kinases, efficient regulation of Fyn achieved through intramolecular binding its SH3 SH2 domains conserved regulatory regions. We have investigated the possibility protein Cbl provides complementary mechanism regulation. show overexpression 293T embryonic kidney Jurkat T-lymphocyte...
TRAIL is an apoptosis-inducing ligand constitutively expressed on liver-resident type 1 innate lymphoid cells (ILC1s) and a subset of natural killer (NK) cells, where it contributes to NK cell anti-tumor, anti-viral, immunoregulatory functions. However, the intrinsic pathways involved in expression ILCs remain unclear. Here, we demonstrate that murine cytotoxic receptor mNKp46/NCR1, ILC1s controls protein expression. Using NKp46-deficient mice, show lack constitutive activated vitro vivo...
The proto-oncogene product Cbl has emerged as a negative regulator of number protein-tyrosine kinases, including the ZAP-70/Syk tyrosine kinases that are critical for signaling in hematopoietic cells. evolutionarily conserved N-terminal kinase-binding domain is required to associate with and their subsequent regulation. However, role remaining C-terminal regions remains unclear. Here, we used COS-7 cell reconstitution system address this question. Analysis series C-terminally truncated...