A5101711039- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Glycosylation and Glycoproteins Research
- Radiation Effects and Dosimetry
- Monoclonal and Polyclonal Antibodies Research
- Aluminum Alloy Microstructure Properties
- Immune Response and Inflammation
- Cytokine Signaling Pathways and Interactions
- Molecular Sensors and Ion Detection
- Aluminum Alloys Composites Properties
- Microstructure and mechanical properties
- Advanced biosensing and bioanalysis techniques
- Carbon and Quantum Dots Applications
- Luminescence and Fluorescent Materials
- Advanced Electron Microscopy Techniques and Applications
- Machine Learning in Materials Science
- Dye analysis and toxicity
- Inflammatory mediators and NSAID effects
- Per- and polyfluoroalkyl substances research
- Air Quality and Health Impacts
- Blood disorders and treatments
- biodegradable polymer synthesis and properties
- Fermentation and Sensory Analysis
- Tea Polyphenols and Effects
- Nanocomposite Films for Food Packaging
Central South University
2024
Shenzhen Technology University
2023-2024
Australian Regenerative Medicine Institute
2024
Monash University
2024
Australian National University
2022-2024
Dalian Medical University
2023-2024
University of Nottingham Ningbo China
2024
Yantai University
2022-2023
ACT Government
2023
Hong Kong University of Science and Technology
2016
Abstract Although circumstantial evidence supports enhanced Toll-like receptor 7 (TLR7) signalling as a mechanism of human systemic autoimmune disease 1–7 , lupus-causing TLR7 gene variants is lacking. Here we describe lupus erythematosus caused by gain-of-function variant. sensor viral RNA 8 9 and binds to guanosine 10 – 12 . We identified de novo, previously undescribed missense Y264H variant in child with severe additional other patients lupus. The selectively increased sensing 2',3'-cGMP...
Lung cancer, with non-small cell lung cancer (NSCLC) being the main subtype, is leading cause of death worldwide, which mainly due to metastasis. Glutathione peroxidase 2 (GPX2), an antioxidant enzyme, involved in tumor progression and Nevertheless, role GPX2 NSCLC metastasis has not been clarified. In this study, we found that expression was elevated tissues high correlated poor prognosis patients NSCLC. addtion, related patient's clinicopathological features, including lymph node...
Abstract Background Nanobodies, also known as VHH or single-domain antibodies, are unique antibody fragments derived solely from heavy chains. They offer advantages of small molecules and conventional making them promising therapeutics. The paratope is the specific region on an that binds to antigen. Paratope prediction involves identification characterization antigen-binding site antibody. This process crucial for understanding specificity affinity antibody-antigen interactions. Various...
Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease with clear genetic component. While most SLE patients carry rare gene variants in risk genes, little known about their contribution to pathogenesis. Amongst them, SH2B3—a negative regulator of cytokine and growth factor receptor signaling—harbors coding over 5% patients. Here, we show that unlike the variant found exclusively healthy controls, SH2B3 are predominantly hypomorphic alleles, failing suppress IFNGR signaling...
Abstract Background Lung cancer is a serious threat to human health and the first leading cause of death. Ferroptosis, newly discovered form programmed cell death associated with redox homeostasis, particular interest in lung cancer, given high oxygen environment cancer. NADPH has reducing properties therefore holds potential resist ferroptosis. Resistance ferroptosis exists but role NADK regulating not been reported yet. Methods Immunohistochemistry (IHC) was used analyse expression 86...
Increased Toll-like receptor 7 (TLR-7) signaling leading to the production of type I interferon (IFN) is an important contributor human systemic lupus erythematosus (SLE). Protein kinase C and casein substrate in neurons 1 (PACSIN1), a molecule that regulates synaptic vesicle recycling, has been linked TLR-7/TLR-9-mediated IFN humans mice, but underlying mechanism unknown. We undertook this study explore pathogenicity de novo PACSIN1 missense variant identified child with SLE.PACSIN1 Q59K...
Cysteine reacts with reactive carbonyls to form thioprolines, which have been demonstrated possess various pharmaceutical properties. Therefore, thioproline formation is considered as a major detoxification pathway for carcinogenic carbonyls. In this study, we report the initial identification of thiazolidine-4-carboxylic acid (1) and 2-methylthiazolidine-4-carboxylic (2), two very common formed by reacting formaldehyde acetaldehyde cysteine in grape wine samples. We developed an isotope...
Autosomal dominant loss-of-function (LoF) variants in cytotoxic T-lymphocyte associated protein 4 (
AbstractPerfluorooctanesulphonyl fluoride (PFOSF), as a main precursor of perfluorooctanesulphonate (PFOS) that is ubiquitous in the environment, has been released to environment with substantial quantity. Determination PFOSF presents significant analytical challenges for using liquid chromatography UV (LC–UV) and fluorescence detection (LC–FLD) due lack chromophore molecular structure. In this study, new method was developed by derivatising 1-naphthol form...
Abstract Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease, with clear genetic component. While most SLE patients carry rare gene variants in risk genes, little known about their contribution to disease pathogenesis. Amongst them, SH2B3 - negative regulator of cytokine and growth factor receptor signaling – harbors coding over 5% patients. Here we show that unlike the variant found exclusively healthy controls, are predominantly hypomorphic alleles. Generation two...
Abstract Nanobodies, also known as VHH or single-domain antibodies, are a unique class of antibodies that consist only heavy chains and lack light chains. Nanobodies possess the advantages both small molecule drugs conventional making them promising therapeutic biopharmaceuticals. Studying characteristics nanobody sequences can aid development design nanobodies. An important challenge in this field is accurately predicting binding sites between nanobodies antigens. The site region where...
Abstract B-1 cells are abundant in peritoneal and pleural cavities produce natural microbial-induced IgM IgA1–4.CD5+ known as “B-1a” represent the largest source of B cell-derived IL-105,6, an important regulator inflammation autoimmunity7. Unlike conventional that produced daily bone marrow, B-1a predominantly generated from foetal precursors maintained by self-renewal8 but molecular mechanisms underpin this stem cell-like property their regulatory potential poorly understood. Here we show...
Abstract While circumstantial evidence supports enhanced TLR7 signaling as a mechanism of human systemic autoimmune disease, we have lacked the proof afforded by lupus-causing gene variants. Here describe monogenic lupus erythematosus (SLE) caused gain-of-function. We identified de novo , novel, missense Y264H variant in child with severe and additional novel or rare variants probands interferonopathies autoimmunity (Aicardi Goutieres Sd, SLE, Sjogren’s juvenile idiopathic arthritis). The...
The purposes of this study are to develop a chitosan suspension for the carbon dioxide (CO2) concentration indication packaged food and investigate changes in CO2 corresponding 2-amino-2-methylpropan-1-ol (AMP) or 2-aminoethanol (monoethanolamine, MEA) addition. Chitosan was prepared by adding (0.1, 0.2, 0.4%) distilled water subsequently pH adjusted 7.0 after addition AMP MEA. Changes turbidity were measured over time under exposure normal atmosphere 100% environment. exposed at environment...