A5084407814- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Cytokine Signaling Pathways and Interactions
- Immune cells in cancer
- Cancer Immunotherapy and Biomarkers
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Phagocytosis and Immune Regulation
- Chemokine receptors and signaling
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cancer Research and Treatments
- Alkaloids: synthesis and pharmacology
- Adenosine and Purinergic Signaling
- Cancer Mechanisms and Therapy
- Cancer, Lipids, and Metabolism
- Autophagy in Disease and Therapy
- Pneumocystis jirovecii pneumonia detection and treatment
- Synthesis and Biological Evaluation
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer Cells and Metastasis
- PI3K/AKT/mTOR signaling in cancer
- Quinazolinone synthesis and applications
- Biological Activity of Diterpenoids and Biflavonoids
- IL-33, ST2, and ILC Pathways
- Cancer, Stress, Anesthesia, and Immune Response
QIMR Berghofer Medical Research Institute
2017-2024
The University of Queensland
2017-2024
Xuzhou Medical College
2023-2024
Kunming Institute of Botany
2012-2019
Chinese Academy of Sciences
2012-2019
Academia Sinica
2015
Kunming University
2015
University of Chinese Academy of Sciences
2013
Northwest Normal University
2010
Abstract Mucosal-associated invariant T (MAIT) cells are innate-like that require MHC class I–related protein 1 (MR1) for their development. The role of MAIT in cancer is unclear, and to date no study has evaluated these vivo this context. Here, we demonstrated tumor initiation, growth, experimental lung metastasis were significantly reduced Mr1−/− mice, compared with wild-type mice. antitumor activity observed mice required natural killer (NK) and/or CD8+ IFNγ. Adoptive transfer into...
Adjuvant immunotherapies targeting CTLA4 or PD-1 recently demonstrated efficacy in the treatment of earlier stages human cancer. We previously using mouse spontaneous metastasis models that neoadjuvant immunotherapy and surgery was superior, compared to adjuvant immunotherapy, eradicating lethal metastatic disease. However, optimal scheduling between how it impacts on development immune-related adverse events (irAEs) remains undefined. Using orthotopic 4T1.2 E0771 spontaneously mammary...
Aberrant tumor blood vessels are prone to propel the malignant progression of tumors, and targeting abnormal metabolism endothelial cells emerges as a promising option achieve vascular normalization antagonize progression. Herein, we demonstrated that salvianic acid A (SAA) played pivotal role in contributing tumor-bearing mice, thereby improving delivery effectiveness chemotherapeutic agent. SAA was capable inhibiting glycolysis strengthening junctions human umbilical vein (HUVECs) exposed...
Ciclopirox olamine (CPX), a fungicide, has been demonstrated as potential anticancer agent. However, the underlying mechanism is not well understood. Here, we found that CPX induced autophagy in human rhabdomyosarcoma (Rh30 and RD) cells. It appeared CPX-induced was attributed to induction of reactive oxygen species (ROS), N-acetyl-L-cysteine (NAC), ROS scavenger antioxidant, prevented this process. Furthermore, observed activation mitogen-activated protein kinases (MAPKs), including...
Five new vobasinyl-ibogan-type bisindole alkaloids, tabernaricatines A-E (1-5), two monomers, F and G (6 7), 24 known indole alkaloids were isolated from the aerial parts of Tabernaemontana divaricata. Alkaloids 1 2 are first possessing a six-membered ring via an ether linkage between C-17 C-21. All compounds except for 3 evaluated their cytotoxicity against five human cancer cell lines; conophylline showed significant bioactivity HL-60, SMMC-7721, A-549, MCF-7, SW480 cells with IC₅₀ values...
Natural killer (NK) cell protection from tumor metastases is a critical feature of the host immune response to cancer, but various immunosuppression mechanisms limit NK effector function. The ectoenzyme, CD39, expressed on tumor-infiltrating myeloid cells, granulocytes, and lymphocytes, including converts extracellular ATP (eATP) into AMP and, thus, potentially suppresses eATP-mediated proinflammatory responses. A CD39-targeting monoclonal antibody (mAb) that inhibits mouse ectoenzyme CD39...
Multiple non-redundant immunosuppressive pathways co-exist in the tumor microenvironment and their co-targeting can increase clinical responses. Indeed, concurrent blockade of CTLA-4 PD-1 patients with advanced melanoma increased responses over monotherapy alone although frequency severity immune related adverse events (irAEs) also increased. Nevertheless, a substantial number still display an innate resistance phenotype are unresponsive to current approved immunotherapies even when utilized...
Neurotransmitter receptors are increasingly recognized to play important roles in anti-tumor immunity. The expression of the ion channel N-methyl-D-aspartate receptor (NMDAR) on macrophages was reported, but role NMDAR tumor microenvironment (TME) remains unknown. Here, we show that activation triggered calcium influx and reactive oxygen species production, which fueled immunosuppressive activities tumor-associated (TAMs) hepatocellular sarcoma fibrosarcoma settings. antagonists, MK-801,...
Abstract The glutamate metabotropic receptor 4 (GRM4) locus is linked to susceptibility human osteosarcoma, through unknown mechanisms. We show that Grm4−/− gene–targeted mice demonstrate accelerated radiation-induced tumor development an extent comparable with Rb1+/− mice. GRM4 expressed in myeloid cells, selectively regulating expression of IL23 and the related cytokine IL12. Osteosarcoma-conditioned media induce cell Il23 a GRM4-dependent fashion, while suppressing Il12. Both mouse...
Cancer stem cells (CSCs) have been implicated in metastasis, relapse, and therapeutic resistance of cancer, so successful cancer therapy may therefore require the development drugs against CSCs or combining anti-CSCs with conventional therapies. The phosphoinositide 3-kinase (PI3K) signaling pathway is one most frequently activated pathways human playing a central role tumorigenesis as well maintenance CSCs. Here, we designed identified B591, dihydrobenzofuran-imidazolium salt, novel...
Tissue inhibitor of metalloproteinase 1 (TIMP1) has been implicated in prostate cancer metastasis. In this study, PC-3M-2B4 cells with TIMP1 knockdown (PC-3M-2B4-shTIMP1) or over-expression (PC-3M-2B4-TIMP1) were generated and an inverse correlation was found between expression cell migration invasion which confirmed vitro vivo. Differential accompanied by variations the ferroptosis-related proteins, glutathione peroxidase 4 (GPX4), transferrin receptor (TFRC), (TF), glutamine cysteine...
Context: Mangiferin has been reported to possess antidiabetic activities. Norathyriol, a xanthone aglycone, the same structure as mangiferin, except for C-glucosyl bond. To our best knowledge, no study conducted determine and compare those two compounds on glucose consumption in vitro.Objective: In this study, effects of norathyriol mangiferin normal insulin resistance (IR) L6 myotubes were evaluated. Simultaneously, potential mechanism effect was also investigated.Materials methods: Normal...
Wnt signaling pathway is aberrantly activated in a variety of cancers, especially colorectal cancer (CRC), because mutations the genes encoding adenomatous polyposis coli (APC), β-catenin and Axin. Small-molecule antagonists Wnt/β-catenin are attractive candidates for developing effective therapeutics CRC. In this study, we have identified novel inhibitor, isopropyl 9-ethyl-1- (naphthalen-1-yl)-9H-pyrido[3,4-b]indole-3- carboxylate (Z86). Z86 inhibited reporter activities expression...
Constitutive activation of the transcription factor nuclear factor-κB (NF-κB) is involved in tumorigenesis and chemo-resistance. As key regulator NF-κB, IKKβ a major therapeutic target for various cancers. Trichothecin (TCN) metabolite isolated from an endophytic fungus herbal plant Maytenus hookeri Loes. In this study, we evaluated anti-tumor activity TCN found that markedly inhibits growth cancer cells with constitutively activated NF-κB. induces G0/G1 cell cycle arrest apoptosis cells,...
Abstract Ten new monoterpenoid indole alkaloids, ochroborines A and B ( 1 2 , resp.), 10‐hydroxyisovallesiachotamine 3 ), 10‐hydroxyisositsirikine 4 10,11‐dimethoxysitsirikine 5 10‐methoxyapoyohimbine 6 10‐hydroxyakuammidine 7 akuammidine 17‐ O ‐ β D ‐glucoside 8 15 α ‐hydroxyapparicine 9 ‐hydroxy‐10‐methoxyapparicine 10 24 known alkaloids were isolated from leaves twigs of Ochrosia borbonica J. F. Gmel . These structures elucidated based on 1D‐ 2D‐NMR, FT‐IR, UV, MS data....
A series of novel (±)-3-substituted fluorene–imidazolium/triazolium salt derivatives were synthesized and their antitumor structure–activity relationship studies reported.
Abstract Tumor-induced immunosuppression is mediated through various mechanisms including engagement of immune checkpoint receptors on effector cells, function immunoregulatory cells such as regulatory T and myeloid-derived suppressor deployment immunosuppressive cytokines TGFβ IL10. IL23 a cytokine that negatively affects antitumor immunity. In this study, we investigated whether IL23-deficient (IL23p19−/−) IL23R-deficient (IL23R−/−) mice phenocopied each other, with respect to their tumor...