A5005625162- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Mosquito-borne diseases and control
- Immunotherapy and Immune Responses
- Viral Infections and Vectors
- MicroRNA in disease regulation
- Malaria Research and Control
- Viral Infections and Outbreaks Research
- Immune Response and Inflammation
- Blood donation and transfusion practices
- IL-33, ST2, and ILC Pathways
- Extracellular vesicles in disease
- Antifungal resistance and susceptibility
- HIV/AIDS Research and Interventions
- CAR-T cell therapy research
- Pleural and Pulmonary Diseases
- Congenital Diaphragmatic Hernia Studies
- Acute Lymphoblastic Leukemia research
- Hernia repair and management
- Fungal Infections and Studies
- Hematopoietic Stem Cell Transplantation
- HIV, Drug Use, Sexual Risk
- Eosinophilic Esophagitis
- Circular RNAs in diseases
- Toxin Mechanisms and Immunotoxins
University of the Witwatersrand
2023
The University of Queensland
2022
University of California, San Francisco
2012-2016
Diabetes Australia
2014
La Jolla Institute for Immunology
2010-2012
Regulatory T cells (Treg cells) are required for immune homeostasis. Chromatin remodeling is essential establishing diverse cellular identities, but how the epigenetic program in Treg maintained throughout dynamic activation process remains unclear. Here we have shown that CD28 co-stimulation, an extracellular cue intrinsically cell maintenance, induced chromatin-modifying enzyme, Ezh2. Treg-specific ablation of Ezh2 resulted spontaneous autoimmunity with reduced Foxp3+ non-lymphoid tissues...
The contribution of T cells to the host response dengue virus (DENV) infection is not well understood. We previously demonstrated a protective role for CD8(+) during primary DENV using mouse-passaged strain and IFN-α/βR(-/-) C57BL/6 mice, which are susceptible infection. In this study, we examine CD4(+) Four I-A(b)-restricted epitopes derived from three nonstructural proteins were identified. expanded activated after infection, with peak activation occurring on day 7. DENV-specific expressed...
microRNAs (miRNA) are essential for regulatory T cell (Treg) function but little is known about the functional relevance of individual miRNA loci. We identified miR-17-92 cluster as CD28 costimulation dependent, suggesting that it may be key Treg development and function. Although overall immune homeostasis was maintained in mice with miR-17-92-deficient Tregs, expression critical accumulation during an acute organ-specific autoimmune disease vivo. Treg-specific loss resulted exacerbated...
MicroRNAs (miRNAs) are crucial for regulatory T cell (Treg) stability and function. We report that microRNA-10a (miR-10a) is expressed in Tregs but not other cells including individual thymocyte subsets. Expression profiling inbred mouse strains demonstrated non-obese diabetic (NOD) mice with a genetic susceptibility autoimmune diabetes have lower Treg-specific miR-10a expression than C57BL/6J resistant mice. Inhibition of vitro leads to reduced FoxP3 levels unstable “exFoxP3” cells....
We previously reported that mice lacking alpha/beta and gamma interferon receptors (IFN-α/βR -γR) uniformly exhibit paralysis following infection with the dengue virus (DENV) clinical isolate PL046, while only a subset of IFN-γR alone virtually no IFN-α/βR develop paralysis. Here, using mouse-passaged variant strain S221, we show in absence IFN-α/βR, signaling through confers approximately 140-fold greater resistance against systemic vascular leakage-associated disease complete protection...
Human postmortem studies of natural dengue virus (DENV) infection have reported systemically distributed viral antigen. Although it is widely accepted that DENV infects mononuclear phagocytes, the sequence in which specific tissues and cell types are targeted remains uncharacterized. We previously mice lacking alpha/beta gamma interferon receptors permit high levels replication show signs systemic disease (T. R. Prestwood et al., J. Virol. 82:8411-8421, 2008). Here we demonstrate within 6 h,...
Background: Cutaneous mucormycosis, while less common than sinonasal or pulmonary infections, can cause widespread tissue necrosis after seemingly innocuous encounters. The most location of cutaneous mucormycosis is the extremities, and extensive infection has been reported trauma orthopedic procedures. Case Report: A 60-year-old female with poorly controlled type 2 diabetes mellitus sustained an open patella fracture a fall. She underwent washout internal fixation cannulated screws cable...
A diaphragmatic defect that permits abdominal contents to herniate into the right side of chest is rare. In adults with right-sided hernias, few occur without a history trauma, and even fewer are symptomatic. This case report illustrates such rare entity an anterolaterally located hernia. Although uncommon easily missed, consequences hernias can be disastrous. The importance combination high clinical suspicion use computed tomography (CT) aid diagnosis, dangers surgical condition being...