A5024831886- Immune Cell Function and Interaction
- Epigenetics and DNA Methylation
- Respiratory viral infections research
- IL-33, ST2, and ILC Pathways
- T-cell and B-cell Immunology
- Eosinophilic Esophagitis
- CAR-T cell therapy research
- Helicobacter pylori-related gastroenterology studies
- Immune responses and vaccinations
- MicroRNA in disease regulation
- Gut microbiota and health
- Immunodeficiency and Autoimmune Disorders
- Immune cells in cancer
- Viral Infectious Diseases and Gene Expression in Insects
- Pediatric health and respiratory diseases
- Virus-based gene therapy research
CTI BioPharma (United States)
2023
University of Washington
2019-2022
University of Michigan–Ann Arbor
2014-2018
Background Chimeric antigen receptor (CAR) T-cell therapies have demonstrated transformational outcomes in the treatment of B-cell malignancies, but their widespread use is hindered by technical and logistical challenges associated with ex vivo cell manufacturing. To overcome these challenges, we developed VivoVec, a lentiviral vector-based platform for engineering T cells. UB-VV100, VivoVec clinical candidate displays an anti-CD3 single-chain variable fragment (scFv) on surface delivers...
Regulatory T (Treg) cells establish tolerance, prevent inflammation at mucosal surfaces, and regulate immunopathology during infectious responses. Recent studies have shown that Delta-like ligand 4 (Dll4) was upregulated on APC after respiratory syncytial virus (RSV) infection, its inhibition leads to exaggerated immunopathology. In the present study, we outline role of Dll4 in Treg cell differentiation, stability, function RSV infection. We found expressed CD11b+ pulmonary dendritic lung...
E-protein transcription factors limit group 2 innate lymphoid cell (ILC2) development while promoting T differentiation from common progenitors. Inhibitors of DNA binding (ID) proteins block in progenitors to allow ILC2 development. However, whether E-proteins influence function upon maturity and activation remains unclear. Mice that overexpress ID1 under control the thymus-restricted proximal
Abstract Notch signaling facilitates inducible Foxp3+ regulatory T cells (iTreg) differentiation. Epigenetic modifications, which include histone are critical in cell Recent genome-wide studies showed that iTreg have increased trimethylation on H3 at lysine 4 (H3K4me3) around Foxp3 loci, but the role of and its underlying epigenetic mechanisms remain elusive. Here we report Delta-like ligand (Dll4) not Jagged1 can activate signaling, facilitate differentiation, H3K4me3 promoter conserved...