A5081024730- Immune Cell Function and Interaction
- Immune cells in cancer
- Immune Response and Inflammation
- T-cell and B-cell Immunology
- Fungal Infections and Studies
- Prostate Cancer Treatment and Research
- Vector-borne infectious diseases
- Epigenetics and DNA Methylation
- IL-33, ST2, and ILC Pathways
- Cancer Immunotherapy and Biomarkers
- Research on Leishmaniasis Studies
- interferon and immune responses
- Galectins and Cancer Biology
- Antifungal resistance and susceptibility
- Inflammasome and immune disorders
- Viral Infections and Vectors
- Pediatric health and respiratory diseases
- Parasites and Host Interactions
- Studies on Chitinases and Chitosanases
- Nail Diseases and Treatments
- Cytokine Signaling Pathways and Interactions
- Immunotherapy and Immune Responses
- Nuclear Structure and Function
- Glycosylation and Glycoproteins Research
- Vector-Borne Animal Diseases
Cedars-Sinai Medical Center
2015-2025
Samueli Institute
2025
University of Michigan
2008-2017
Michigan United
2010-2014
Hospital Universitário da Universidade de São Paulo
2013
Queensland University of Technology
2012
Universidade de Ribeirão Preto
2011
Ann Arbor Center for Independent Living
2011
Universidade de São Paulo
2003-2008
Clinics Hospital of Ribeirão Preto
2008
Ligands from dying cells are a source of Toll-like receptor (TLR) activating agents. Although TLR3 is known to respond RNA necrotic cells, the relative importance this response in vivo during acute inflammatory processes has not been fully explored. We observed involvement activation experimental polymicrobial septic peritonitis and ischemic gut injury absence an exogenous viral stimulus. In TLR3-deficient mice, increased chemokine/cytokine levels neutrophil recruitment characterized initial...
Macrophages (MΦ) play an essential role in innate immune responses and can either display a pro-inflammatory, classically activated phenotype (M1) or undergo alternative activation program (M2) promoting regulation. M-CSF is used to differentiate monocytes into MΦ IFN-γ IL-4+IL-13 further polarize these cells towards M1 M2, respectively. Recently, differentiation using only GM-CSF has been described induce M1- M2-like phenotype, In this study, we combined both approaches by differentiating...
Endogenous regulatory T (Treg) cells are involved in the control of infections, including Leishmania infection mice. viannia braziliensis is main etiologic agent cutaneous leishmaniasis (CL) Brazil, and it also responsible for more severe mucocutaneous form. Here, we investigated possible involvement Treg immune response human skin lesions caused by L. infection. We show that functional can be found patients with CL. These express phenotypic markers cells--such as CD25, cytotoxic...
Abstract The long-term persistence of pathogens in a host is hallmark certain infectious diseases, including schistosomiasis, leishmaniasis, and paracoccidioidomycosis (PCM). Natural regulatory T (Treg) cells are involved control the immune responses, response to pathogens. Because CTLA-4 constitutively expressed Treg it acts as negative regulator cell activation patients with PCM, here we investigated involvement systemic local PCM. We found that leukocyte subsets were similar controls,...
Abstract Paracoccidioidomycosis, a debilitating pulmonary mycosis, is caused by the dimorphic fungus Paracoccidioides brasiliensis. The infection results in formation of granulomas containing viable yeast cells that are fungal sources for disease reactivation. Because CD4+CD25+ regulatory T (Tregs) lesions patients with paracoccidioidomycosis, migration Treg dependent on axis chemokine-chemokine receptors, and CCR5 ligands produced P. brasiliensis-induced lesions, we investigated role...
Influenza A viral infections have been identified as the etiologic agents for historic pandemics, and contribute to annual mortality associated with acute pneumonia. While both innate acquired immunity are important in combating influenza virus infection, mechanism connecting these arms of immune system remains unknown. Recent data indicated that Notch is an bridge between antigen-presenting cells (APCs) T cell communication circuits plays a central role driving overcome disease. In present...
Summary Haematophagous arthropod vectors such as mosquitoes, tsetse flies, sandflies and ticks have evolved salivary immunomodulatory factors that prevent the vertebrate host from rejecting them meanwhile enhancing pathogen transmission. As dendritic cells (DC) play a major role in immune responses, we studied effects of Rhipicephalus sanguineus tick saliva on DC differentiation maturation. Flow cytometry analysis revealed addition to bone marrow inhibits decreased population differentiated...
TLRs are a family of receptors that mediate immune system pathogen recognition. In the respiratory system, TLR activation has both beneficial and deleterious effects in asthma. For example, clinical data indicate TLR6 exerts protective Here, we explored mechanism or mechanisms through which mediates this effect using mouse models Aspergillus fumigatus-induced house dust mite antigen-induced (HDM antigen-induced) chronic Tlr6-/- mice with fungal- HDM asthma exhibited substantially increased...
Objective: Sepsis represents an acute life-threatening disorder resulting from a dysregulated host response. For patients who survive sepsis, there remains long-term consequences, including impaired inflammation, as result of profound immunosuppression. The mechanisms involved in this long-lasting deficient immune response are poorly defined. Approach and Results: was induced using the murine model cecal ligation puncture. Following full recovery period sepsis physiology, mice were subjected...
Abstract Interleukin (IL)-33 is an important cytokine in the tumour microenvironment; it known to promote growth and metastasis of solid cancers, such as gastric, colorectal, ovarian breast cancer. Our group demonstrated that IL-33/ST2 pathway enhances development squamous cell carcinoma (SCC). Conversely, other researchers have reported IL-33 inhibits progression. In addition, crosstalk between IL-33, cancer cells immune SCC remains unknown. The aim this study was investigate effect on...
Immunosuppression following severe sepsis remains a significant human health concern, as long-term morbidity and mortality rates of patients who have recovered from life-threatening septic shock remain poor. Mouse models indicate this immunosuppression may be partly due to alterations in myeloid cell function; however, the effect on subsequent CD4(+) T-cell responses unclear. In present study, T cells mice subjected an experimental model (cecal ligation puncture (CLP)) were analyzed vitro....
207 Background: Circulating tumor cells (CTCs) with a very-small-nuclear (vsn) phenotype (i.e., vsnCTCs) in prostate cancer (PCa) represent distinct subset of CTCs characterized by nuclei smaller than 8.5 μm. Our previous studies established link between vsnCTCs and the presence visceral metastasis. Emerging evidence suggests that reduction emerin (EMD), nuclear envelope protein, contributes to PCa metastasis is associated shape instability. This study aims validate as biomarker metastatic...
Abstract Background: Circulating tumor cells (CTCs) with a very-small-nuclear phenotype (vsnCTCs) in prostate cancer (PCa) are characterized by nuclei smaller than 8.5 μm. Our previous studies established an association between vsnCTCs and visceral metastasis. Reduction of emerin (EMD), nuclear envelope protein, contributes to PCa metastasis shape instability. Here we investigated the correlation EMD expression vsnCTC its clinical impact. Methods: We analyzed CTCs from 93 mCRPC patients...
Engagement of programmed death-1 (PD-1) with its two ligands [programmed death ligand-1 (PD-L1) and PD-L2] has been associated the suppression tumor-reactive T cells; however, underlying mechanism for this T-cell dysfunction is not clear. We hypothesized that PD-1 PD-L1 signals are, in part, responsible squamous cell carcinoma (SCC) escape from immune antitumor regulation by modulation tumor environment. In present study, we used a multistage model SCC to examine role PD-1/PD-L1 activation...