A5087041812- CAR-T cell therapy research
- Cancer Immunotherapy and Biomarkers
- Ubiquitin and proteasome pathways
- ATP Synthase and ATPases Research
- Glioma Diagnosis and Treatment
- Inflammatory mediators and NSAID effects
- Immunotherapy and Immune Responses
- Adenosine and Purinergic Signaling
- Lysosomal Storage Disorders Research
- Autophagy in Disease and Therapy
- Calcium signaling and nucleotide metabolism
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer, Lipids, and Metabolism
- Antiplatelet Therapy and Cardiovascular Diseases
- Cytokine Signaling Pathways and Interactions
- Immune Cell Function and Interaction
- Eicosanoids and Hypertension Pharmacology
- interferon and immune responses
- Biochemical and Molecular Research
- Epigenetics and DNA Methylation
- Hepatitis B Virus Studies
- Infrared Thermography in Medicine
- Hepatitis C virus research
- Glycosylation and Glycoproteins Research
- Cancer-related gene regulation
The University of Texas MD Anderson Cancer Center
2007-2025
The University of Texas Health Science Center at Houston
2016-2020
OncoImmune (United States)
2011-2014
Queensland University of Technology
2012
University of Michigan
2009-2011
Anesthesiology and Surgical Oncology Research Group
2002
Shanghai Institute of Applied Physics
1996
Academia Sinica
1981
Increased transcriptional activity of beta-catenin resulting from Wnt/Wingless-dependent or -independent signaling has been detected in many types human cancer, but the underlying mechanism Wnt-independent regulation is poorly understood. We have demonstrated that AKT, which activated downstream epidermal growth factor receptor signaling, phosphorylates at Ser552 vitro and vivo. AKT-mediated phosphorylation causes its disassociation cell-cell contacts accumulation both cytosol nucleus...
Abstract Recent evidence suggests that several deubiquitinases (DUB) are overexpressed or activated in tumor cells and many contribute to the transformed phenotype. Agents with DUB inhibitory activity may therefore have therapeutic value. In this study, we describe mechanism of action WP1130, a small molecule derived from compound Janus-activated kinase 2 (JAK2) activity. WP1130 induces rapid accumulation polyubiquitinated (K48/K63-linked) proteins into juxtanuclear aggresomes, without...
Abstract Purpose: The blood–brain barrier (BBB) inhibits adequate dosing/penetration of therapeutic agents to malignancies in the brain. Low-intensity pulsed ultrasound (LIPU) is a safe method temporary BBB disruption (BBBD) enhance chemotherapeutic delivery tumor and surrounding brain parenchyma for treatment glioblastoma. Experimental Design: We investigated if LIPU could efficacy anti–PD-1 C57BL/6 mice bearing intracranial GL261 gliomas, epidermal growth factor receptor variant III...
Abstract Programmed cell death 1 ligand (PD-L1) is a key driver of tumor-mediated immune suppression, and targeting it with antibodies can induce therapeutic responses. Given the costs associated toxicity PD-L1 blockade, alternative strategies are needed. Using reverse-phase protein arrays to assess drugs in use or likely enter trials, we performed candidate drug screen for inhibitors expression identified verteporfin as possible small-molecule inhibitor. Verteporfin suppressed basal...
Aim: To ascertain the maximum tolerated dose (MTD)/maximum feasible (MFD) of WP1066 and p-STAT3 target engagement within recurrent glioblastoma (GBM) patients. Patients & methods: In a first-in-human open-label, single-center, single-arm 3 + design Phase I clinical trial, eight patients were treated with until disease progression or unacceptable toxicities. Results: absence significant toxicity, MFD was identified to be 8 mg/kg. The most common adverse event grade 1 nausea diarrhea in 50% No...
Myelodysplastic syndrome and acute myeloid leukemia (AML) belong to a continuous disease spectrum of malignancies with poor prognosis in the relapsed/refractory setting necessitating novel therapies. Natural killer (NK) cells from patients display global dysfunction impaired killing capacity, altered metabolism, an exhausted phenotype at single-cell transcriptomic proteomic levels. In this study, we identified that was mediated through cross-talk between NK blasts cell-cell contact. cell...
Activation of Src kinase plays important roles in the development many neoplasias. Most previous studies focused on deregulation activity. The deregulated protein synthesis and stability mediating malignant phenotypes cancer cells, however, have been neglected. While investigating signal transduction pathways contributing to ErbB2-mediated metastasis, we found that ErbB2-activated breast cells had higher metastatic potentials also increased activity compared with ErbB2 low-expressing cells....
Abstract The mechanism by which aspirin consumption is linked to significant reductions in the incidence of multiple forms cancer and metastatic spread distant tissues, resulting increased patient survival not well understood. In this study, using colon as an example, we provide both vitro (cell culture) vivo (chemically induced mouse model cancer) evidence that profound antineoplastic action may be associated with aspirin's ability irreversibly inhibit COX-1–mediated platelet activation,...
Abstract Purpose: Patients with central nervous system (CNS) tumors are typically treated radiotherapy, but this is not curative and results in the upregulation of phosphorylated STAT3 (p-STAT3), which drives invasion, angiogenesis, immune suppression. Therefore, we investigated combined effect an inhibitor whole-brain radiotherapy (WBRT) a murine model glioma. Experimental Design: C57BL/6 mice underwent intracerebral implantation GL261 glioma cells, WBRT, treatment WP1066, blood–brain...
Activation of STING (
Abstract To determine the efficacy of a novel and safer (for gastrointestinal tract) aspirin (aspirin-PC) in preclinical models ovarian cancer, vitro dose–response studies were performed to compare growth-inhibitory effect aspirin-PC versus on three human (A2780, SKOV3ip1, HeyA8) mouse (ID8) cancer cell line over an 8-day culture period. In vivo studies, test drugs studied alone presence VEGF-A inhibitor (bevacizumab or B20), due emerging role for platelets tumor growth following...
Abstract Chimeric antigen receptor (CAR) natural killer (NK) cell immunotherapy offers a promising approach against cancer. However, the molecular mechanisms governing CAR NK activity remain poorly understood. In this study, we identified transcription factor cAMP response element modulator (CREM) as pivotal regulator of function. Using Raji model, single-cell RNA sequencing revealed marked upregulation CREM in cells during peak anti-tumor after adoptive transfer. expression correlated with...
AbstractHeat shock protein 90β (Hsp90β) is involved in many cellular functions. However, the posttranslational modification of Hsp90β, especially response to apoptotic stimulation, not well understood. In this study, we found that Hsp90β was cleaved by activated caspase-10 under UVB irradiation. Caspase-10 activation, turn, depended on caspase-8, which directly. Autocrine secretion FAS ligand and upregulated expression induced irradiation contributed activation caspase-10, at D278, P293,...
In primary mammalian cells, expression of oncogenes such as activated Ras induces premature senescence rather than transformation. We show that homozygous deletion glycogen synthase kinase (GSK) 3beta (GSK3beta-/-) bypasses induced by mutant Ras(V12) allowing mouse embryo fibroblasts (MEFs) well immortalized MEFs to exhibit a transformed phenotype in vitro and vivo. Both catalytic activity Axin-binding GSK3beta are required optimally suppress The GSK3beta-/-, but not GSK3beta+/+ results...
MiRNAs can silence a wide range of genes, which may be an advantage for targeting heterogenous tumors like glioblastoma. Osteopontin (OPN) plays both oncogenic role in variety cancers and immune modulate macrophages. We conducted genome profiling bioinformatic analysis to identify miR-181a/b/c/d as potential miRNAs that target OPN. Luciferase assays confirmed the binding Expression levels OPN were evaluated by using quantitative real-time PCR enzyme-linked immunosorbent assay mouse human...
Non-steroidal anti-inflammatory drugs (NSAIDs) such as aspirin and sulindac are effective for colorectal cancer prevention in humans some animal models, but concerns over gastro-intestinal (GI) ulceration bleeding limit their potential chemopreventive use broader populations. Recently, the combination of with a phospholipid, packaged PL-ASA, was shown to reduce GI toxicity small clinical trial. However, these studies were done relatively short periods time. Since prolonged, regular is needed...