A5100408949- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Circular RNAs in diseases
- Renal and related cancers
- Protein Kinase Regulation and GTPase Signaling
- Myofascial pain diagnosis and treatment
- RNA modifications and cancer
- Breast Cancer Treatment Studies
- Lipid metabolism and disorders
- Angiogenesis and VEGF in Cancer
- Genomics, phytochemicals, and oxidative stress
- Viral Infectious Diseases and Gene Expression in Insects
- Cytokine Signaling Pathways and Interactions
- Cancer-related gene regulation
- Plant Physiology and Cultivation Studies
- Diabetes and associated disorders
- Genetic factors in colorectal cancer
- Connective Tissue Growth Factor Research
- Cell death mechanisms and regulation
- Pathogenesis and Treatment of Hiccups
- Kruppel-like factors research
- Cancer Research and Treatments
- Toxoplasma gondii Research Studies
- Plant and Fungal Interactions Research
China Medical University
2025
Fujian Medical University
2024
Union Hospital
2024
Beijing Anzhen Hospital
2024
Capital Medical University
2024
State Key Laboratory of Kidney Diseases
2024
Ningbo University
2024
Chinese PLA General Hospital
2024
Tumor Hospital of Guangxi Medical University
2021
Zhengzhou City Hospital
2021
Activation of Src kinase plays important roles in the development many neoplasias. Most previous studies focused on deregulation activity. The deregulated protein synthesis and stability mediating malignant phenotypes cancer cells, however, have been neglected. While investigating signal transduction pathways contributing to ErbB2-mediated metastasis, we found that ErbB2-activated breast cells had higher metastatic potentials also increased activity compared with ErbB2 low-expressing cells....
Catalase is a major effector in the defense of aerobic cells against oxidative stress. Recent studies have shown that catalase activity stimulated by c-Abl and Arg tyrosine kinases. Little, however, otherwise known about mechanisms responsible for regulation. The present work demonstrates mouse deficient both exhibit increased stability. results also show subject to ubiquitination degradation 26S proteosome. Significantly, dependent on c-Abl- Arg-mediated phosphorylation Y231 Y386. In...
The purpose of this study was to explore the biological functions mTOR and AMPK signaling pathways in colon cancer (CC). potential molecular mechanisms by which oleanolic acid (OA) induces autophagy apoptosis were also investigated. analyzed GeneCards, Search Tool for Retrieval Interacting Genes (STRING), Database Annotation, Visualization Integrated Discovery (DAVID). Least absolute shrinkage selection operator (LASSO) regression analysis used obtain prognostic survival data CC patients...
Abstract Background Cisplatin is an extensively used chemotherapy agent for lung cancer, but its drug resistance serves as a huge obstacle failure of cancer patients. Hence, researchers aimed to determine role sirtuin 3 (SIRT3) considering action in cisplatin cancer. Methods The expression patterns SIRT3, FOXO3, and CDT1 were determined using RT‐qPCR Immunoblotting Immunofluorescence Co‐IP adopted detect co‐localization interaction FOXO3 CDT1. Loss‐ gain‐function assays conducted roles...
BACKGROUND AND PURPOSE Ursolic acid (UA) has been extensively used as an anti‐leukaemic agent in traditional Chinese medicine. In the present study, we investigated ability of UA to induce apoptosis human leukaemia cells relation its effects on caspase activation, Mcl‐1 down‐regulation and perturbations stress‐induced signalling pathways such PKB JNK. EXPERIMENTAL APPROACH Leukaemia were treated with after which apoptosis, JNK evaluated. The anti‐tumour activity was evaluated using xenograft...
Background: Gastric cancer (GC) ranks as the fifth leading cause of mortality, with stem cells (CSCs) playing a critical role in tumor progression and resistance to chemotherapy. Conventional chemotherapy often fails effectively target these cells. BATF2, suppressor, is known for its gastric cancer, but influence on cell-like properties response remains unclear. Methods: Single-cell RNA sequencing (scRNA-seq) analysis was performed 9 samples evaluate expression regulatory function BATF2. In...
Renal cell carcinoma (RCC) is the most common kidney malignancy and has a poor prognosis owing to its resistance chemotherapy. Recently, microRNAs (miRNAs or miRs) have been shown role in cancer metastasis potential as prognostic biomarkers cancer. In present study, we aim explore of miR-100 RCC by targeting nicotinamide adenine dinucleotide phosphate oxidase 4 (NOX4) through mammalian target rapamycin (mTOR) pathway. Initially, microarray-based gene expression profiling was used identify...
Lymph node metastasis is an important step in the progression of colorectal cancer (CRC); however, underlying mechanisms are still unknown. The aim present study was to identify gene expression pattern during lymph CRC and upstream microRNAs (miRNAs) explore detail. A total 305 differently expressed genes (DEGs) were identified, including 227 upregulated 78 downregulated metastasis. Pathway process enrichment analysis demonstrated that DEGs significantly enriched 'NABA CORE MATRISOME',...
BCL-2 Associated athanogene 1 (BAG-1) and Xeroderma pigmentosum group D (XPD) are involved in the nucleotide excision repair pathway DNA repair. We aimed to investigate whether polymorphisms BAG-1 XPD have effects on chemotherapy sensitivity survival patients with advanced non-small-cell lung cancer (NSCLC) treated vinorelbine combined cisplatin (NP) regimen. A total of 142 diagnosed NSCLC were recruited current study. NP regimen was applied for all eligible patients. Polymerase chain...
The present study aimed to identify a specific circular RNA (circRNA) for early diagnosis of gastric cancer (GC).Totally 82 patients with GC, 30 chronic nonatrophic gastritis and atrophic were included in this study. Four the GC selected screening. Total from malignant adjacent tissue samples was extracted, circRNAs four screened. According screening results, eight most upregulated downregulated statistically significant association identified by real-time fluorescent quantitative polymerase...
Citrus leaf blotch virus (CLBV) is a member of the genus Citrivirus, in family Betaflexiviridae. It has been reported CLBV could infect kiwi, citrus and sweet cherry China. Of 289 samples from six regions China, 15 were detected to be infected with this study. The complete genome four isolates was obtained Reikou Sichuan (CLBV-LH), Yura Wase Zhejiang (CLBV-YL), Bingtangcheng Hunan (CLBV-BT), Fengjie 72-1 Chongqing (CLBV-FJ), respectively. While they all represented 8 747 nucleotides...
Lung cancer is the leading cause of global cancer-associated mortality, therefore it important to reveal molecular mechanisms lung progression and develop novel therapeutic targets. The results present study identified that manganese-12 acetate (Mn12Ac) was able significantly inhibit migration invasion A549 cells. Western blotting demonstrated treatment with Mn12Ac upregulate E-cadherin, downregulate N-cadherin vimentin. It also by a quantitative polymerase chain reaction analysis reduce...
The bronze gudgeon (Coreius heterodon) and the congeneric species largemouth guichenoti), two endemic fish in China, are important economic fishes local areas. is distributed Yangtze River Huanghe basin, whereas only middle upper reaches of River. Here, we sequenced complete mitochondrial genomes compared evolutionary rate differences between species. C. heterodon guichenoti 16,611 16,612 bp, respectively. Both mitogenome sequences contain 13 protein-coding genes, 2 rRNA subunits, 22 tRNAs 1...
pp56lck is a member of the src family tyrosine kinases mainly expressed in T lymphocytes. Src havebeen Implicated control cell growth and differentiation different types, but mechanism regulation these enzymes poorly understood. In order to characterize distinct species pp56lck, we have produced highyields enzymatically active wild type using eukaryotic baculovirus expression system Spodopterafrugiperda insect cells (Sf9). We find that various baculoviral are not only differentially...