A5081020266- Dialysis and Renal Disease Management
- Muscle and Compartmental Disorders
- Erythropoietin and Anemia Treatment
- Renal and related cancers
- Chronic Kidney Disease and Diabetes
- Electrolyte and hormonal disorders
- Chronic Myeloid Leukemia Treatments
- Tissue Engineering and Regenerative Medicine
- Epigenetics and DNA Methylation
- Hemophilia Treatment and Research
- Acute Myeloid Leukemia Research
- Mesenchymal stem cell research
- Hormonal Regulation and Hypertension
- Healthcare cost, quality, practices
- Birth, Development, and Health
- Inflammasome and immune disorders
- Lipid metabolism and disorders
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Genetic Syndromes and Imprinting
- Gout, Hyperuricemia, Uric Acid
- Nephrotoxicity and Medicinal Plants
- Single-cell and spatial transcriptomics
- Mycobacterium research and diagnosis
- Apelin-related biomedical research
- Cardiovascular Effects of Exercise
State Key Laboratory of Kidney Diseases
2019-2024
Chinese PLA General Hospital
2019-2024
Chinese People's Liberation Army
2021-2023
PLA Academy of Military Science
2021-2023
Qingdao University
2015-2023
Qingdao Municipal Hospital
2020-2023
National Clinical Research
2021
Seventh People's Hospital of Dalian
2019
Qingdao Women and Children's Hospital
2015-2018
Ruijin Hospital
2014-2017
Renal inflammation is a critical pathophysiological characteristic of diabetic kidney disease (DKD). The mechanism the inflammatory response complicated, and there are few effective treatments for renal that can be used clinically. Insulin-like growth factor-binding protein 5 (IGFBP5) an important secretory related to fibrosis in several tissues. Studies have shown IGFBP5 level significantly upregulated DKD. However, function its DKD remain unclear. Here, we showed levels were increased...
Abstract Long non‐coding RNA (lncRNA) plays an important role in the renal inflammatory response caused by hyperuricaemia. However, underlying molecular mechanisms through which lncRNA is involved endothelial injury induced hyperuricaemia remain unclear. In this study, we investigated regulatory of lncRNA‐HOTAIR high concentration uric acid (HUA)–induced injury. We established mouse model and vitro (UA)–induced human umbilical vein cell (HUVEC) model. HUA‐treated HUVECs mice, observed...
Rhabdomyolysis (RM) is a complex set of clinical syndromes that involves the rapid dissolution skeletal muscles. Mortality from RM approximately 10%. This study aimed to develop an interpretable and generalizable model for early mortality prediction in patients.Retrospective analyses were performed on two electronic medical record databases: eICU Collaborative Research Database Medical Information Mart Intensive Care III database. We extracted data first 24 h after patient ICU admission....
Acute kidney injury (AKI) has emerged as a major public health problem affecting millions of people worldwide without specific and satisfactory therapies due to the lack an effective delivery approach. In past few decades, hydrogels present infinite potential in localized drug delivery, while their poor adhesion moist tissue isotropic diffusion character always restrict therapeutic efficiency may lead unwanted side effects. Herein, we proposed novel strategy for AKI via customizable...
Background RARRES1 is a tumor suppressor protein, and its expression suppressed in various cells. However, whether it participates the immune response kidney renal clear cell carcinoma (KIRC) unknown, defined mechanism not clear. Therefore, of KIRC worthy investigation. Methods We analysed function with The Cancer Genome Atlas (TCGA) database. Kaplan–Meier curve was adopted to estimate survival. RARRES1-correlated genes were obtained from UALCAN database subjected Gene Ontology (GO)...
Circular RNAs (circRNAs) play an essential role in the pathogenesis of malignant tumors, including gastric cancer (GC). However, effect circ_0032821 on GC remains largely unknown.QRT-PCR assay was employed to examine levels circ_0032821, CEP128 mRNA and miR-1236-3p. RNase R digestion utilized verify feature circ_0032821. Cell Counting Kit-8 (CCK-8) transwell were adopted evaluate cell proliferation metastasis. The level glycolysis evaluated through detecting ECAR, OCR, lactate production,...
The treatment of chronic kidney diseases (CKDs) by different approaches using mesenchymal stem cells (MSCs) has made great strides. In this study, we aimed to explore the potential mechanism gelatin microcryogels (GMs) as a cell therapeutic vector block progression CKD.In vivo, pedicled omentum valve with MSC-loaded GMs was packed onto 5/6 nephrectomized kidneys derived from rats. effects were evaluated. vitro, TNF-α, TGF-β, and MSCs added medium HK-2 culture system, key genes involved in...
Kidney renal papillary cell carcinoma (KIRP) accounts for 10–15% of (RCC). The need to find more therapeutic targets KIRP is urgent because most targeted drugs have limited effects on advanced KIRP. Insulin-like growth factor (IGF) binding protein 5 (IGFBP5) a secreted related proliferation, adhesion, migration, the inflammatory response and fibrosis; these functions are independent IGF. In our study, we determined expression IGFBP5 with data from database Cancer Genome Atlas (TCGA). We...
Abstract Background UMOD is exclusively produced by renal epithelial cells. Recent genome-wide association studies (GWAS) suggested that common variants in gene are closely connected with the risk of CKD. However, a comprehensive and objective report on current status research lacking. Therefore, we aim to conduct bibliometric analysis quantify identify quo trending issues past. Methods We collected data from Web Science Core Collection database used Online Analysis Platform Literature...
Summary Intron 1 inversion (Inv1) is a recurrent causative mutation of haemophilia A (HA) and responsible for 1–5% severe HA. Inv1 occurs as result intra-chromosomal homologous recombination between int1h-1 within intron int1h-2 located in approximately 125 kb telomeric to the F8 gene. In this report, we presented previously undescribed aberrant type with complex genomic rearrangement pedigree The breakpoints were identified by genome walking technique; copy number variations (CNVs) gene X...
Abstract This study aims to investigate the value and determine accuracy of spleen stiffness in predicting degree esophageal varices bleeding patients with liver cirrhosis. The age, gender, stiffness, gastroscopy results 124 inpatients or outpatients cirrhosis healthy volunteers, who underwent both FibroScan testing fasting state, were retrospectively analyzed. According results, volunteers divided into six groups: varicose bleeding, severe varices, moderate mild no control group. Then,...
Abstract Background Mesenchymal stem cells (MSCs) have been reported to promote regeneration in both subjects with acute kidney injury (AKI) and chronic disease (CKD), but their efficacy remains limited, probably because most of the accumulate lungs, liver, spleen after an intravenous infusion. Therefore, ultrasound-guided administration MSCs represents a possible approach solve this problem. The greater omentum is used cell survival due its rich vasculature. We hypothesized that combined...
Renal inflammation plays key roles in the pathogenesis of diabetic kidney disease (DKD). Immune cell infiltration is main pathological feature progression DKD. Sodium glucose cotransporter 2 inhibitor (SGLT2i) were reported to have antiinflammatory effects on While heterogeneity and molecular basis treatment with SGLT2i DKD remains poorly understood.
Although mesenchymal stem cells (MSCs) have been proven to be appropriate candidates for the treatment of AKI-CKD, their efficacy is limited and variable. Astilbin (AST) had a protective effect on MSCs from oxidative stress via ROS-scavenging, however, whether it can improve MSCs' renoprotection underlying mechanism need elucidated. AST-pretreated were administered intravenously into ischemia–reperfusion injury mice models renal function, pathological changes inflammation. Were evaluated. In...
Background: Roxadustat, a hypoxia-inducible factor prolyl-hydroxylase inhibitor (HIF-PHI), has been used to treat anemia in patients with chronic kidney disease (CKD). However, its safety and efficacy remain controversial. Methods: The PubMed, EMBASE, Science Citation Index, Cochrane Central Register of Controlled Trials, Clinical Trial Registries databases were searched for relevant studies published up April 2021. We identified randomized controlled trials (RCTs) comparing roxadustat...
Abstract Objectives This study aimed to develop and validate an easy-to-use intensive care unit (ICU) illness scoring system evaluate the in-hospital mortality for very old patients (VOPs, over 80 years old). Methods We performed a multicenter retrospective based on electronic ICU (eICU) Collaborative Research Database (eICU-CRD), Medical Information Mart Intensive Care (MIMIC-III CareVue MIMIC-IV), Amsterdam University Centers (AmsterdamUMCdb). Least Absolute Shrinkage Selection Operator...